Human papillomavirus-associated cancers: A growing global problem

Bansal, Anshuma; Singh, Mini P.; Rai, Bhavana

doi:10.4103/2229-516x.179027

Cited by 150 publications

(69 citation statements)

References 50 publications

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“…In addition, other viruses with oncogenic potential such as EBV and MCPV that have been detected in the nasopharyngeal tract, tonsils, salivary glands, and lungs may play an important role ( Baez et al, 2015 ; Pezzuto et al, 2015 ; Gupta et al, 2016 ). At present, there are insufficient reports describing the epidemiology of viral coinfections in tumors of the larynx, so studies in this regard could contribute to clarify their association with the carcinogenic progression and to facilitate preventive strategies ( Bansal, Singh & Rai, 2016 ). A total of 195 specimens of laryngeal tumor tissue were included in the present study.…”

Section: Discussionmentioning

confidence: 99%

Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Vazquez-Guillen

Palacios-Saucedo

Rivera-Morales

et al. 2018

PeerJ

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BackgroundHuman papillomavirus (HPV) is recognized as an important risk factor for laryngeal carcinogenesis. Although HPV-16 and 18 have been strongly implicated, the presence of other high-risk HPV (HR-HPV) genotypes or the coinfection with Epstein-Barr virus (EBV) or Merkel cell polyomavirus (MCPV) may increase the risk, but their etiological association has not been definitively established.MethodsWe characterized the genotype-specific HPV and the frequency of EBV and MCPV infections through the detection of their DNA in 195 laryngeal specimens of squamous cell carcinoma (SCC) histologically confirmed.ResultsHPV DNA was detected in 93 (47.7%) specimens. HPV-11 was the most frequent with 68 cases (73.1%), and HPV-52 was the most frequently HR-HPV found with 51 cases, which corresponds to 54.8% of all HPV-positive specimens. EBV DNA was detected in 54 (27.7%) tumor tissue specimens of which 25 (46.3%) were in coinfection with HPV. MCPV DNA was detected only in 11 (5.6%) cases of which 5 (45.4%) were in coinfection with an HR-HPV. No association between the presence of DNA of the three examined viruses and the patient smoking habits, alcohol consumption, age, the keratinization status, differentiation grade, or localization of the tumor in the larynx were found.DiscussionHPV-52 was the most prevalent HR-HPV, which may suggest that this and other genotypes in addition to HPV-16 and 18 could be considered for prophylaxis. However, further studies including non-cancer larynx cases and the evaluation of other molecular markers and viral co-infection mechanisms are needed to determine the role of the different HR-HPV genotypes, EBV, and MCPV in the etiology of SCC of the larynx.

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Section: Discussionmentioning

confidence: 99%

Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Vazquez-Guillen

Palacios-Saucedo

Rivera-Morales

et al. 2018

PeerJ

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“…More than 200 HPV types have been identified (Ghedira et al, 2016) and some had been confirmed to be associated with certain diseases, mainly cancers. Replicated evidence support that HPV infection causes cervical cancer in virtually 100% of cases and it is associated with the development of an important percentage of penile, vaginal, anal, vulvar, and oropharyngeal cancers and pre-cancers (Bansal, Singh & Rai, 2016). Epidemiological research has reported that 5.2% of all cancers worldwide can be attributed to HPV infection (Steben & Duarte-Franco, 2007).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

Cao

et al. 2020

PeerJ

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Background Human papilloma virus (HPV) infection is one of the most common sexually transmitted infections among women worldwide. The current study’s main objective is to report the prevalence and distribution of HPV types in an urban population in Beijing, China. Methods All the eligible female participants aged ≥18 years were recruited from the Aerospace Center Hospital in Beijing, China between 2014 and 2018. A total of 21 HPV types were detected by the polymerase chain reaction (PCR) reverse dot blot method and fluorescence quantitative PCR method. Results In total, 12 high risk HPV types and nine low risk HPV types were detected. The HPV-positive rates were 8.85% in 2014, 7.16% in 2015, 7.60% in 2016, 8.31% in 2017, and 7.72% in 2018, respectively, in an urban population in Beijing, China. Overall, no significant differences in the HPV-positive rates were found over the five years. The peak prevalence of HPV infection in all types was observed in age group of 20–24 in all types. HPV52 was the dominant HPV type across the five years . Among all 21 HPV types, HPV66, HPV26, and HPV59 were ranked the top three in coinfection occurrence. Conclusions Our findings are very helpful for HPV screening and vaccination. The associations between gynaecological diseases and the HPV types with high prevalence, particularly HPV52, warrant further investigation.

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“…CANCERPLEX includes probes that correspond to HPV and EBV biomarkers. Infection with these agents confers an increased risk of developing several different types of cancer, including head and neck and cervical cancer [ 25 , 26 ] and have implications on tumor classification, prognosis and treatment strategies [ 27 , 28 ]. The proficiency of the assay to detect these viruses was evaluated by testing a set of previously characterized virus-positive and -negative human DNAs, including clinical FFPE tumors, HeLa cells and two DNA samples derived from EBV-transformed cell lines.…”

Section: Resultsmentioning

confidence: 99%

Clinical Application of a Cancer Genomic Profiling Assay to Guide Precision Medicine Decisions

Eifert¹,

Pantazi²,

Sun³

et al. 2017

Per. Med.

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Aim:Develop and apply a comprehensive and accurate next-generation sequencing based assay to help clinicians to match oncology patients to therapies.Materials & methods:The performance of the CANCERPLEX® assay was assessed using DNA from well-characterized routine clinical formalin-fixed paraffin-embedded (FFPE) specimens and cell lines.Results:The maximum sensitivity of the assay is 99.5% and its accuracy is virtually 100% for detecting somatic alterations with an allele fraction of as low as 10%. Clinically actionable variants were identified in 93% of patients (930 of 1000) who underwent testing.Conclusion:The test's capacity to determine all of the critical genetic changes, tumor mutation burden, microsatellite instability status and viral associations has important ramifications on clinical decision support strategies, including identification of patients who are likely to benefit from immune checkpoint blockage therapies.

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Human papillomavirus-associated cancers: A growing global problem

Cited by 150 publications

References 50 publications

Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Infection and coinfection by human papillomavirus, Epstein–Barr virus and Merkel cell polyomavirus in patients with squamous cell carcinoma of the larynx: a retrospective study

Prevalence and type distribution of human papillomavirus in a Chinese urban population between 2014 and 2018: a retrospective study

Clinical Application of a Cancer Genomic Profiling Assay to Guide Precision Medicine Decisions

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