Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association

Marzouki, Hani; Biron, Vincent L.; Harris, Jeffrey R.; O’Connell, Daniel A.; Seikaly, Hadi

doi:10.1002/hed.24388

Head & Neck

2016

DOI: 10.1002/hed.24388

|View full text |Cite

Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association

Hani Marzouki

Vincent L. Biron

Jeffrey R. Harris

et al.

Abstract: In our male population, there was no significant association between anogenital and OPSCCs. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2100-E2102, 2016.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2023

Publication Types

Select...

Article3

Relationship

Self Cite2

Independent1

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 40 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 HNSCC has been associated with tobacco and alcohol consumptions and human papillomavirus (HPV) infection is another highrisk factor for increasing incidence, especially in the male. [2][3][4][5] Although male patients have more than twice the incidence of HNSCC compared to female patients, they have a better overall survival than the females. [6][7][8] This gender disparity in overall survival may be dependent on the individual patient's age, race, tumor location, stage, HPV status, and treatment.…”

mentioning

confidence: 99%

Y‐Chromosome‐Linked Genes Are Associated With Sex‐Related Head‐Neck Squamous Cell Carcinoma Survival

Feng

Zhang

Chou

et al. 2023

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

ObjectiveTo define novel gene biomarkers for prognosis of head and neck squamous cell carcinoma (HNSCC) patients' survival.Study DesignRetrospective study.SettingThe Cancer Genome Atlas (TCGA) HNSCC RNA‐Seq dataset.MethodsCoexpressed gene clusters were extracted from TCGA RNA‐seq data using our previously published method (EPIG). Kaplan‐Meier estimator was then used for overall survival‐relevant analysis, with patients partitioned into 3 groups based on gene expression levels: female, male_low, and male_high.ResultsMale had better overall survival than female and male with higher expression level of Y‐chromosome‐linked (Y‐linked) genes had significantly better survival than those with lower expression levels. In addition, male with a higher expression level of Y‐linked genes showed even better survival when they have a higher level of coexpressed cluster of genes related to B or T cell immune response. Other clinical conditions related to immune responses also consistently showed favorable effects on the Y‐linked genes for survival estimation. Male patients with higher expression level of Y‐linked genes also have significantly higher tumor/normal tissue (T/N) ratio of those genes and higher level of several immune responses related clinical measurements (eg, lymphocyte and TCR related). Male patients with lower expression level of Y‐linked genes benefited from radiation‐only treatment.ConclusionsThe favorable role of a cluster of coexpressed Y‐linked genes in HNSCC patients' survival is potentially associated with elevated level of immune responses. These Y‐linked genes could serve as useful prognostic biomarkers for HNSCC patients' survival estimation and treatment.

show abstract

mentioning

confidence: 99%

Y‐Chromosome‐Linked Genes Are Associated With Sex‐Related Head‐Neck Squamous Cell Carcinoma Survival

Feng

Zhang

Chou

et al. 2023

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

Epigenetics of oropharyngeal squamous cell carcinoma: Opportunities for novel chemotherapeutic targets

Lindsay

Seikaly

Biron

2017

Journal of Otolaryngology - Head & Neck Surgery

Self Cite

View full text Add to dashboard Cite

Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications include DNA methylation, histone post-translational modifications, small and non-coding RNAs. Alterations in epigenetic profiles cause deregulation of fundamental gene expression pathways associated with carcinogenesis. The role of epigenetics in oropharyngeal squamous cell carcinoma (OPSCC) has recently been recognized, with implications for novel biomarkers, molecular diagnostics and chemotherapeutics. In this review, important epigenetic pathways in human papillomavirus (HPV) positive and negative OPSCC are summarized, as well as the potential clinical utility of this knowledge.This material has never been published and is not currently under evaluation in any other peer-reviewed publication.

show abstract

Practices regarding human Papillomavirus counseling and vaccination in head and neck cancer: A Canadian physician questionnaire

Anderson

Isaac

Jeffery

et al. 2017

Journal of Otolaryngology - Head & Neck Surgery

Self Cite

View full text Add to dashboard Cite

BackgroundHuman papillomavirus (HPV) has recently been implicated as a causative agent in a rapidly growing number of oropharyngeal cancers. Emerging literature supports the hypothesis that HPV vaccination may protect against HPV-related head and neck cancer (HNC) in addition to HPV-related cervical and anogenital disease. While the association between HPV infection and cervical cancer is widely understood, its relation to HNC is less well known. The purpose of this study was to better understand HPV counseling practices for infection and vaccination in relation to HNC of primary care physicians (PCPs), Obstetricians/Gynecologists (OBGYNs), and Otolaryngology - Head and Neck Surgeons (OHNSs) in Canada.MethodsA Canada-wide electronic questionnaire regarding counseling practices on HPV infection, transmission, and vaccination was designed and distributed to PCPs, OBGYNs, and OHNSs across Canada through electronic and paper-based methods. Basic Descriptive statistics were used to analyze responses.ResultsIn total, 337 physicians responded (239 family physicians, 51 OHNSs, 30 OBGYNs, and 17 pediatricians). Three out of four PCPs reported routine counseling of their patients regarding HPV infection, transmission, and vaccination. Among this group, 68% reported “never” or “rarely” counseling patients that HPV can cause HNC. The most commonly reported reason that PCPs cited for not counseling was a lack of knowledge. The majority of OHNSs (81%) and OBGYNs (97%) counseled patients regarding HPV infection, transmission, and vaccination. However, very few OHNSs (10%) regularly counseled patients with HPV-related HNC about HPV-related anogenital cancer. Similarly, very few OBGYNs (18%) regularly counseled patients with HPV related cervical/anogenital cancer about HPV related HNC.ConclusionsThe rate of counseling on HPV infection, transmission, and vaccination in relation to HNC among PCPs is low. The most common reason is a lack of knowledge. Specialists rarely counsel patients with confirmed HPV-related cancer about other HPV-related malignancies. More research is needed on the relationship between different HPV-related cancers in order to better inform counseling practices.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Human papillomavirus–associated oropharyngeal squamous cell carcinoma and anogenital cancers in men: Epidemiologic evaluation of association

Abstract: In our male population, there was no significant association between anogenital and OPSCCs. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2100-E2102, 2016.

Cited by 3 publications

References 40 publications

Y‐Chromosome‐Linked Genes Are Associated With Sex‐Related Head‐Neck Squamous Cell Carcinoma Survival

Y‐Chromosome‐Linked Genes Are Associated With Sex‐Related Head‐Neck Squamous Cell Carcinoma Survival

Epigenetics of oropharyngeal squamous cell carcinoma: Opportunities for novel chemotherapeutic targets

Practices regarding human Papillomavirus counseling and vaccination in head and neck cancer: A Canadian physician questionnaire

Contact Info

Product

Resources

About