Human papillomavirus deoxyribonucleic acid may not be detected in non-genital benign papillomatous skin lesions by polymerase chain reaction

Kambiz, Kamyab Hesari; Kaveh, Davoodi; Maede, Damavandi; Ayatollahi, Hossein; Aghazadeh, Nessa; Rahbar, Ziba; Alireza, Ghanadan

doi:10.4103/0019-5154.135475

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…They are considered a sign of aging skin in general and extrinsic aging, particularly due to chronic ultraviolet (UV) exposure. In contrast, a viral hypothesis suggesting the involvement of HPV has not been substantiated by recent studies 19, 20 . Nevertheless, HPV p16 expression has been found in genital SKs at a frequency of between 65% and 69.6% 21, 22 .…”

Section: Pathogenesismentioning

confidence: 86%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

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Section: Pathogenesismentioning

confidence: 86%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

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“…and Kambiz et al. could not find a positive association between HP viruses and the development of SK 43,44 …”

Section: Pathogenesismentioning

confidence: 84%

Seborrheic keratosis

Barthelmann¹,

Butsch²,

Lang³

et al. 2023

J Deutsche Derma Gesell

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Summary Seborrheic keratosis (SK) is the most common benign epidermal tumor in clinical dermatological practice. This review summarizes current knowledge about the clinical and histological appearance, epidemiology, pathogenesis, and treatment of SK. There are different subtypes of SK based on clinical presentation and histologic findings. Several factors, including age, genetic predisposition, and possibly also exposure to ultraviolet radiation, are thought to contribute to the development of SK. The lesions can occur on all areas of the body except for the palms and soles, but the most common sites are the face and upper trunk. The diagnosis is usually made clinically, and in some cases by dermatoscopy or histology. Many patients prefer to have the lesions removed for cosmetic reasons although there is no medical indication. Treatment options include surgical therapy, laser therapy, electrocautery, cryotherapy, and topical drug therapy, which is currently in development. Treatment should be individualized depending on the clinical picture and patient preference.

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“…[ 1 2 3 5 6 9 ] IFK has histologic similarities to irritated seborrheic keratosis, keratoacanthoma, trichilemmoma, and verruca vulgaris, but most studies have found IFK to be consistently negative for HPV by immunohistochemistry, in situ hybridization and polymerase chain reaction. [ 1 2 3 10 11 12 13 14 ]…”

Section: Discussionmentioning

confidence: 99%