Human papillomavirus DNA detection in women with normal and abnormal cervical Pap cytology

Zhao, Chengquan; Yang, Huijie

doi:10.1016/j.mpdhp.2012.06.007

Cited by 2 publications

(3 citation statements)

References 58 publications

(63 reference statements)

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“…To date, over 150 different types of HPV have been fully identified, approximately 40 of which are known to infect epithelial cells in the anogenital region (13). Human papillomavirus types infecting the genital tract can be divided into high-risk and low-risk groups, depending on their potential to cause cancer (13,14).…”

Section: Introductionmentioning

confidence: 99%

“…Human papillomavirus types infecting the genital tract can be divided into high-risk and low-risk groups, depending on their potential to cause cancer (13,14). Low-risk HPV types (such as HPV6 and HPV11) commonly cause benign warts and low-grade premalignant lesions, which regress and do not progress to cancer.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, high-risk HPV types are associated with the development of anogenital cancer (12,14). Certain strains of HPV are associated with different risk levels of transformation into genital tract in both males and females (13,(15)(16)(17). High-risk HPV16 and HPV18, which are found in high frequencies in cervical cancer, account for approximately two-thirds of all cervical carcinomas worldwide (HPV16 as the most frequent type) (16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

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The Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Women with Normal Cytology in North of Iran

Daneshvar

Haghshenas

Majleci

et al. 2016

Jundishapur J Microbiol

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Background: Cervical cancer is a leading cause of mortality in women. Infection with high-risk human papillomavirus (HPV) is recognized as an important etiological factor for the development of cervical cancer. On the other hand, cervical cancer screening can detect abnormal cervical cells and diagnose cervical cancer in the early stages. Objectives: This study was performed to determine and analyse the distribution of HPV genotypes in normal cervical tissues, using polymerase chain reaction in Mazandaran province in North of Iran. Methods: This cross-sectional study was performed during 2012 -2015. Tissue samples from the cervix were collected from 450 women, referring to a healthcare centre in Mazandaran province, Iran. Pap smear was used to monitor any abnormalities or unusual findings. Also, GP5 + / GP6 + primers were applied for the detection of HPV DNA in the specimens. Afterwards, positive samples were selected to perform high-risk HPV genotyping, using the HPV HCR DNA genotyping kit. Results: In this study, 431 (95.78%) samples were found to be normal on the Pap smear test, while 19 (4.22%) samples were abnormal. We found that the rate of positive HPV DNA was 10.22% in the tissue cervix samples. Human papillomavirus DNA was detected in 8.12% (35 of 431) of the normal tissues and 57.89% (11 of 19) of the abnormal tissues. From the 46 HPV DNA positive samples, 19 (41.30%) were HPV16, 9 (19.57%) of which were HPV18 and 1 (2.17%) was HPV45. In this study, the highest prevalence of HPV DNA was found in women within the age range of 20-24 years, which constitutes 20 (28.17%) of the HPV DNA positive samples. Conclusions: Cervical cancer screening, comprising of both Pap test and HPV testing, is an essential part of the routine health care for women as it can facilitate the detection of abnormal cervical cells. HPV infection can produce abnormal Pap test results; also, certain types of HPV are associated with cancer. Therefore, it is important to diagnose abnormal cervical tissues before the development of cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Women with Normal Cytology in North of Iran

Daneshvar

Haghshenas

Majleci

et al. 2016

Jundishapur J Microbiol

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HPV and Its high-risk Genotypes in Middle Eastern Countries: A meta-analysis

et al. 2020

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Background: HPV is the main cause of cervical cancer. Determining the geographic distribution of HPV genotypes is a major step in the implementation of cervical cancer screening. This study aimed to evaluate the prevalence of HPV and its high-risk genotypes in Middle Eastern countries. Materials & methods: MEDLINE, ISI Web of Science, PubMed, EMBASE, Scopus and ProQuest were searched from 2005 to 2018. The quality of the studies was determined by Strengthening the Reporting of Observational Studies in Epidemiology checklist. Fixed/random effects models were conducted to estimate the pooled prevalence. Results: The pooled prevalence of HPV was 12.3 and 5.2%. The prevalence of HPV in Africa (22%) was higher than that in Eurasia (8.3%) and Asia (12.6%). The prevalence of HPV was 14.4, 8.3, 22 and 10.2% in Iran, Turkey, Egypt and Arab countries, respectively. The prevalence of high-risk-HPV in the above-mentioned countries was 6.5, 6.2, 6.5 and 3.7%. Conclusion: Prevalence of HPV was increased in the Middle East. This highlights the need for public education, screening and vaccination programs.

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Human papillomavirus DNA detection in women with normal and abnormal cervical Pap cytology

Cited by 2 publications

References 58 publications

The Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Women with Normal Cytology in North of Iran

The Prevalence and Genotype Distribution of Cervical Human Papillomavirus DNA in Women with Normal Cytology in North of Iran

HPV and Its high-risk Genotypes in Middle Eastern Countries: A meta-analysis

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