Human papillomavirus genotyping among women with cervical abnormalities in Ulaanbaatar, Mongolia

Abstract

Few studies on human papillomavirus (HPV) have been conducted in Mongolia. This study was performed to evaluate the prevalent HPV genotypes and their associations with cytology and demographic and behavioral characteristics in Mongolian women with cervical abnormalities. Methods: Exfoliated cell samples of 100 women who had a previous history of cervical abnormality were collected. Cytological interpretation was conducted microscopically and HPV genotyping was performed using the Roche Linear Array test. Study questionnaires were completed. Results: Overall, 25 HPV genotypes were detected in 47% of participants, and the most prevalent were HPV 16, 52, 58, and 33. Cytological examination revealed 12% of participants had atypical squamous cells of undetermined significance (ASC-US), 8% had low-grade squamous intraepithelial lesions (LSIL), 7% had high-grade squamous intraepithelial lesions (HSIL), and 14% had squamous cell carcinoma (SCC), while 59% of women had a normal cytology. HPV 16 was the most common type among women with a normal cytology and cervical cancer. However, women with cervical abnormalities including LSIL and HSIL were predominantly infected with HPV 52. Moreover, women aged <35 years had a significantly higher risk of HPV infection than those in the other age groups (p < 0.05). Conclusions: The prevalent trend of HPV genotypes observed in this cohort differs from that reported previously in Mongolia. These data may contribute to developing an effective strategy for cervical cancer prevention in Mongolia.

Human papilloma and other DNA virus infections of the cervix: A population based comparative study among tribal and general population in India

“…The prevalence of multiple HPV infections among normal samples ranges from 2.6–20.2% while such infections are reported to be higher in case of cervical abnormalities and lesions [15,18,24,34]. In a recent study conducted among 100 women with cervical abnormality, 68% of the samples demonstrated multiple HPV infections [35]. The HPV subtypes, therefore, may exhibit both cooperative and competitive interactions during cervical carcinogenesis [36] which needs to be validated using molecular studies.…”

Characteristics of high-risk human papillomavirus infection in women with abnormal cervical cytology: a population-based study in Shanxi Province, China

“…It was reported that the prevalence of HPV infection in women with abnormal cervical cytology was 47.0% to 72.8% [15,16]. HPV prevalence increased with increasing severity of cervical lesions from 12% in normal cytology to 89% in invasive cervical cancer [17].…”

“…To date, more than 100 HPV genotypes have been identified [5], of which approximately 40 HPV types are associated with the genital tract infection [6]. Among the numerous members of the HPV family, 15 HR-HPV genotypes (types 16,18,31,33,35,39,45,51,52,53,56,58,59, 66 and 68) are etiologically associated with more than 98% of cervical cancers. Effective prophylactic vaccines against the most important carcinogenic HPV types are available, but they do not cover main types of HPV in different countries and regions [7].…”

<p>Prevalence and Genotype Distribution of High-Risk Human Papillomavirus Infection in Women with Abnormal Cervical Cytology: A Population-Based Study in Shanxi Province, China</p>

“…The prevalence of HPV infection in women with abnormal cervical cytology is 47.0%-72.8%. 18,19 HPV prevalence increases with increasing severity of cervical lesions: from 12% in normal cytology to 89% in invasive cervical cancer. 20 The prevalence of HR-HPV in women with abnormal cervical cytology is 92.4%, significantly higher than those with normal cytology (71%).…”