Human Papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients

León, David Cantú de; Montiel, Delia Pérez; Němcová, Jana; Mykyskova, Iva; Turcios, Elmer; Villavicencio, Verónica; Cetina, Lucely; Coronel, Alberto Rodríguez; Hes, Ondraj

doi:10.1186/1471-2407-9-26

Cited by 61 publications

(57 citation statements)

References 16 publications

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“…In this study, the presence of HPV was detected in 63.6% of breast cancer samples, while only 4.5% of benign pathology tissue biopsies were positive for this virus. This detection frequency is within the previously published worldwide range, with a prevalence ranging from 10-86% 4,5,14,16,[29][30][31][32] , where the works by Akil, et al 4 in 2008 and Antonsson, et al 30 in 2011 detected 61.06 and 50% of HPV DNA-positive cases by means of multiplex PCR and assembly PCR, respectively.…”

Section: Discussionsupporting

confidence: 84%

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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Introduction: Breast cancer represents the leading cause of cancer-related death in the Venezuelan female population. Many risk factors favoring its appearance have been reported; however, human papillomavirus and Epstein-Barr virus have been associated in the past few decades as potential risk factors in the development of this malignancy. Objective: To detect the presence of human papillomavirus and Epstein-Barr virus in breast cancer biopsies in order to establish a possible link between infection with these viral agents and the development of this pathology. Methods: Fresh biopsies were collected from patients with breast cancer and patients with breast benign pathology attending the Hospital Universitario de Caracas for surgery. Human papillomavirus detection was made using the INNO-LIPA ® HPV Genotyping Extra commercial kit (Innogenetics), and Epstein-Barr virus genome was detected with Epstein-Barr Virus BMLF1 commercial kit (Maxim Biotech, Inc.). Results: 63.6 and 13.6% of breast cancer cases were positive for human papillomavirus and Epstein-Barr virus DNA, respectively, whereas the benign pathology samples had 4.5% positivity for each one of the viruses; 42.90% of breast cancer samples had mixed infection with low and high oncogenic risk human papillomavirus genotypes. Conclusion: We can suggest that human papillomavirus and Epstein-Barr virus are important risk factors for breast cancer; however, studies allowing for the role of these viruses in the development of the disease to be elucidated are required. (creativecommons.org/licenses/by-nc-nd/4.0/). HPV and EBV in breast cancer 104

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Section: Discussionsupporting

confidence: 84%

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Ladera¹,

Fernándes²,

López³

et al. 2022

GAMO

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“…Another definitive method to detect molecular contamination is the comparison of sequences of experimental samples with those of positive controls. Some researchers sequenced the amplifications obtained in the PCR reactions, but they did not provide enough details to judge the quality of the sequencing procedure [49, 51, 53, 61, 63, 64]. …”

Section: Causes Of False-positive Resultsmentioning

confidence: 99%

“…Most studies employed an initial PCR amplification using the standard commercially available primers used to screen HPV in cervical tissue [41, 42, 44, 47, 50-52, 54, 55, 57-61, 63, 65, 66, 69, 73, 76, 77, 80, 81]. These primer sets, like GP, MY, SPF, are within the L1 region, which codes most of the proteins in the viral capsid, and they more accurately detect the best known genital and/or oncogenic HPV types, i.e., HPV 6, 11 , 16, 18, 31, 33, 35, 39, 40, 42, 45, and 51–59.…”

Section: Resultsmentioning

confidence: 99%

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

2018

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Background: Although the association of human papillomavirus (HPV) with many cancers is well established, the involvement of HPV in breast cancer remains controversial. The purpose of this study is to perform a comprehensive review of the results and methods used to demonstrate that HPV markers are present in human breast cancer, and how well these studies fulfil the criteria for proving the viral etiology of a cancer. Study Design: We conducted a search for molecular studies published until November 2016 that relate human breast cancer to HPV. Results: Forty-three original molecular studies were found, some of which compared cases to nonneoplastic controls. Some investigations did not identify HPV in mammary tissue, but others identified it with different frequencies of positivity, varying between 1.2 and 86%. In most case-control studies (21/24 studies), positivity in cases was found to be higher than in controls, but odds ratios and confidence intervals were not reported. Conclusion: The results are controversial. However, they arouse a great interest in the potential participation of HPV in breast carcinogenesis, but rather as an essential cause-effect participant, at least as a co-participant in some cases. The circumstance of HPV positivity in breast cancer can be criticized, but the elements that clearly demonstrate it in a number of cases are also relevant.

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“…De León et al (2009) (23) found 29% (15/51) of HPV DNA by PCR in breast carcinomas within an average age of 53 years and average tumor size of 9 cm, of which ten of the cases (66,6%) were positive to HPV-16, three (20%) to HPV-18, and two cases (13,4%) positive to both of them. In the benign conditions group (43 cases), all were negative to HPV-DNA.…”

Section: The Possible Involvement Of Hpv In Breast Cancermentioning

confidence: 99%

“…Damin tissue. In some studies, high-risk HPV was detected in normal tissue and in low levels of cancer (19,23,25,27,29,30,33) . The definition of normal tissue is important, as non-malignant areas can contain atypia with high-risk of cancer recorrence.…”

Section: The Possible Involvement Of Hpv In Breast Cancermentioning

confidence: 99%

The Possible Involvement of HPV in Breast Cancer

Rodrigues¹

2011

J bras doenças sex transm

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The exact role that viruses play in tumorigenesis is unclear, but it seems they are responsible for causing one of a series of steps required for the development of cancer. The first step for infering whether a particular cancer is caused by this virus is showing the virus in tissue degradation. Molecular techniques, in comparison with the evaluation of antibodies in immunohistochemistry, are the most effective techiniques to establish the presence of the virus. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been found in breast carcinomas worldwide. The high-risk human papillomavirus may be an important risk factor for breast carcinogenesis and metastasis. The role of human papillomavirus in breast carcinogenesis is still unclear and may ultimately be determined by monitoring the incidence of future breast cancer among women vaccinated for human papillomavirus types as high-risk.

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Human Papillomavirus (HPV) in breast tumors: prevalence in a group of Mexican patients

Cited by 61 publications

References 16 publications

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Presence of Human Papillomavirus and Epstein-Barr Virus in Breast Cancer Biopsies as Potential Risk Factors

Is Human Papilloma Virus Associated with Breast Cancer? A Review of the Molecular Evidence

The Possible Involvement of HPV in Breast Cancer

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