Human papillomavirus infection among head and neck squamous cell carcinomas in southern China

Abstract

Human papillomavirus (HPV) related tumours account for a significant proportion of head and neck squamous cell carcinomas (HNSCCs) in developed countries. They respond better to chemo- and radio-therapy, and have a better stage specific prognosis. To establish their prevalence in China, we assessed a series of histology confirmed HNSCCs collected in Zhejiang and Guangdong provinces by PCR for HPV DNA and by immunohistochemistry for p16 protein status. Among 303 HNSCCs, HPV DNA was detected in 26.4%, with HPV16 DNA in 71% of these. Of HNSCC located in the oropharynx, 38.55% (32/83) were HPV+ve. In this series, p16 status was a relatively poor predictor of HPV status as detected by PCR. The stage specific survival time of HPV+ HNSCCs was significantly longer than for HPV- HNSCC. HPV status should be assessed for oropharyngeal cancers in China to assist with appropriate management, and prophylaxis against HPV infection should be considered to reduce the incidence of this disease.

The frequency of high-risk human papillomavirus types, HPV16 lineages, and their relationship with p16INK4a and NF-κB expression in head and neck squamous cell carcinomas in Southwestern Iran

“…The accession number of reference sequences of each sublineage used for phylogenetic analysis in this study was indicated by white triangles HPV16 was the most common type detected in this study, a finding that is consistent with many other studies [25,31,34,36]. Although some studies demonstrated a strong association between HPV16 infection and tonsillar and base of tongue SCCs [36], however, our findings on the prevalence of HPV16 showed no large differences in various anatomical locations of the HNSCC cancers. Such a disagreement can be explained by the large number of tongue and oral cavity SCC cases in our study which can generally lead to observed differences in frequencies of viral infection.…”

Male papillomavirus infection and genotyping in the Qingyuan area

“…Therefore, the head of the penis, the body of the penis and the scrotum, the urethral orifice were common sites of HPV infection. A previous study by Ni et al [7] identified 43.7% HPV infection rate in the tumor tissues of male patients with head and neck squamous cell carcinoma. Chen et al [8] reported that the male HPV infection rate in a clinic in Shanghai was 47.8% by sampling scrotum or penis.…”

Diagnostic and prognostic impact of E6/E7 mRNA compared to HPV DNA and p16 expression in head and neck cancers: an Egyptian study

“…Our results demonstrated there was no notable association linking HPV-positive HNSCCs to any of age, gender, smoking history, site, stage, or grade. In contrast, many studies found that HPV positive HNSCCs were significantly more prevalent in younger, nonsmoker males, with predominance of the oropharyngeal primary site [53,54].…”