Human papillomavirus type 16 is Detected in transitional cell carcinomas and squamotransitional cell carcinomas of the cervix and endometrium

Abstract

BACKGROUND The etiologic role of human papillomavirus (HPV) in a variety of squamous neoplasms, including malignant and premalignant lesions of the cervix, is well established. The presence of HPV, predominantly HPV types 16 and 18, in adenocarcinomas of the endometrium has also been reported, although less commonly. Although rare, transitional cell carcinoma (TCC) in the female genital tract, including such sites as the cervix, endometrium, and ovary, has been described. HPV, however, has not been previously studied in TCC of the female genital tract, the etiology of which is uncertain. METHODS Eight cases of primary TCC of the endometrium and six cases of primary TCC of the cervix were retrieved from the files of the Armed Forces Institute of Pathology and the University of Texas Southwestern Medical Center. Slides stained with hematoxylin and eosin were reviewed, and tumor tissue was obtained and analyzed for the presence of HPV types 6, 11, 16, 18, 31, and 33 by polymerase chain reaction (PCR). RESULTS HPV was detected by PCR in 4 of 6 TCCs of the cervix (67%) and in 2 of 8 TCCs of the endometrium (25%), using HPV general primers and specific primers to HPV type 16. PCR for HPV using specific primers to HPV types 6 and 11, 18, 31, and 33 were negative in all cases. CONCLUSIONS The results of this study demonstrated that HPV type 16 was present in a proportion of primary TCCs of the cervix and endometrium. These findings support the hypothesis that these rare neoplasms are similar, with regard to risk factors, to the more commonly occurring squamous cell carcinomas of the cervix, and suggest that HPV may play an etiologic role in at least a proportion of these tumors. Cancer 1998;83:521‐527. © 1998 American Cancer Society.

Squamotransitional Cell Carcinoma of the Vagina: Diagnosis and Clinical Management

“…Squamotransitional cell carcinomas (STCC) of the uterine cervix and endometrium were described as early as 1986 by Randall et al and later by Alboress-Savedra and Young [12] and Koenig et al [9]. These tumors differen- tiate from benign papillary squamous tumors and from verrucous carcinoma for their papillary architecture and their resemblance to urinary tract tumors [5,9,12].…”

“…These tumors differen- tiate from benign papillary squamous tumors and from verrucous carcinoma for their papillary architecture and their resemblance to urinary tract tumors [5,9,12]. The urothelial differentiation of STCCs has been correlated by some authors to the common embryonic origin of the urogenital tract [22].…”

“…STCC of the uterine cervix is an established tumor variant and "subtypes" have been tentatively categorized by researchers in a number of studies [9][10][11][12]. In 1997, Koenig et al [9] reported a series of 32 STCCs of the cervix and proposed a classification based on morphology into three groups: squamous cell carcinoma (SCC), mixed squamous and transitional (squamotransitional) cell carcinoma (STCC), and transitional cell carcinoma (TCC) [9] (Tables 2 and 3).…”

Transitional cell carcinoma of the endometrium and endometrial carcinoma with transitional cell differentiation: a clinicopathologic study of 5 cases and review of the literature

“…The presence of HPV has been previously studied in TCCs of the endometrium in 3 reports. Lininger et al [15] demonstrated HPV 16 in 2 (25%) of 8 TCCs of the endometrium. However, Labontè et al [6] found no evidence of HPV 6, 11, 16, or 18 in the case they reported.…”

Inverted papilloma of the cervix and vagina: report of 2 cases of a rare lesion associated with human papillomavirus 42

“…Most have represented papillary transitional carcinomas or papillary squamotransitional carcinomas [1][2][3][4][5][6][7][8]. There have been 3 reported cervical neoplasms resembling inverted transitional papilloma of the urinary bladder [1,9]; but, as far as we are aware, a similar lesion has not been described in the vagina.…”