2001
DOI: 10.1046/j.1365-2133.2001.04033.x
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Human papillomavirus type 58 in Bowen's disease of the elbow

Abstract: Human papillomavirus (HPV) can be detected in skin lesions of Bowen's disease, particularly on the fingers, and its genotype is associated with mucosal/genital types of HPV. We report herein an 85-year-old woman who had HPV-associated Bowen's disease on her elbow. HPV-58 DNA was detected in the lesion by polymerase chain reaction with restriction fragment length polymorphism and by Southern blot hybridization. In situ hybridization revealed numerous hybrid cells in the nuclei of the upper epidermis and stratum… Show more

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Cited by 20 publications
(19 citation statements)
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“…In our study, ISH for HPV types 6,11,16,18,30,31,33,35,45,51, and 52 failed to reveal the presence of HPV DNA. The lack of detection of HPV DNA may have been due to low levels of expression of HPV DNA, lower than what ISH is capable of, or due to the presence of an HPV type not detected by our genomic probes.…”
Section: Discussioncontrasting
confidence: 75%
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“…In our study, ISH for HPV types 6,11,16,18,30,31,33,35,45,51, and 52 failed to reveal the presence of HPV DNA. The lack of detection of HPV DNA may have been due to low levels of expression of HPV DNA, lower than what ISH is capable of, or due to the presence of an HPV type not detected by our genomic probes.…”
Section: Discussioncontrasting
confidence: 75%
“…10,15,17 Multiple studies have detected the presence of HPV by ISH in extragenital Bowen disease. [10][11][12][13][15][16][17][18] However, these findings have not been consistently reported, with some studies failing to find the association of Bowen disease with HPV infection. Lu et al 21 analyzed 91 cases of extragenital Bowen disease with ISH for HPV types 1,2,4,6,7,11,12,15,16,18,26,36,37,39,42,55, and 59 followed by PCR, and were not able to detect HPV in any specimens.…”
Section: Discussionmentioning
confidence: 98%
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“…Some isolated cases of acral BD involving HPV have been reported [14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24]. However, the fact that few series have evaluated HPV prevalence in extragenital cutaneous BD [25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36]led us to conduct a systematic search for HPV in 50 patients with BD with either immunocompetent or immunosuppressive status.…”
Section: Discussionmentioning
confidence: 99%
“…However, both in immunocompetent and immunosuppressed patients, the relation between this virus and extragenital Bowen’s disease (BD; in situ carcinoma) is much more controversial and has only been investigated in a few studies. Several isolated cases of acral BD in association with HPV have been reported [14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24], but only a few series (generally with limited numbers of patients) have concerned other cutaneous localizations [25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36]. …”
Section: Introductionmentioning
confidence: 99%