Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.

Gissmann, Lutz; Wolnik, L.; Ikenberg, Hans; Koldovsky, Ursula; Hg, Schnürch; Hausen, Harald zur

doi:10.1073/pnas.80.2.560

Cited by 767 publications

(307 citation statements)

References 12 publications

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“…Nonetheless, malignant transformation of lesions caused by HPV 11 does occur, although it is an infrequent occurrence (15,16). DNA sequence analysis has shown that specific viral mutations are associated with malignant transformation, demonstrating the role of specific viral genes in oncogenesis (17).…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis, occurring in fewer than 1% of cases. We describe a 23-year-old patient with pulmonary papillomas who developed a fatal squamous cell carcinoma of the lung. PCR-based human papillomavirus (HPV) typing showed the presence of HPV 11 DNA in both benign papillomas and invasive carcinoma. A review of the literature reveals four reports of malignant transformation of juvenile-onset recurrent respiratory papillomatosis in which HPV typing was performed. Similar clinical features are noted in all of the reports; specifically, each case has arisen in a young adult man with a history of papillomatosis since childhood. In each of the cases, HPV 11 was identified in association with the squamous cell carcinoma. Although HPV 11 is uncommonly associated with the development of invasive carcinoma at other sites, these findings suggest that it is correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis. KEY WORDS: Human papillomavirus 11, Recurrent respiratory papillomatosis, Squamous cell carcinoma. Mod Pathol 2000;13(8):914-918Juvenile-onset recurrent respiratory papillomatosis (RRP) is characterized by numerous squamous papillomas of the respiratory tract secondary to infection with human papillomavirus (HPV) types 6 and 11 (1, 2). HPV is thought to be acquired at the time of vaginal delivery in the presence of genital lesions, and patients typically present with symptoms of hoarseness or respiratory obstruction in childhood or adolescence. In the majority of cases, the papillomas are confined to the larynx; only 5% of patients exhibit more distal involvement of the trachea, and involvement of lung parenchyma occurs in fewer than 1% of cases (1, 2). Pulmonary involvement by RRP is twice as frequent in males than in females and is associated with an aggressive clinical course. Most patients require numerous excisions, frequently require tracheostomy, and ultimately die as a result of respiratory insufficiency or infections (2). Malignant transformation of laryngeal or pulmonary lesions is a very rare event in the absence of prior irradiation; fewer than 20 cases are reported in the English literature (3-6). It remains unclear whether the risk of malignant transformation is dependent on the HPV serotype involved.We describe a patient with pulmonary involvement by RRP who developed a squamous cell carcinoma of the lung. Polymerase chain reaction (PCR) typing performed at postmortem examination showed the presence of HPV 11 DNA in both the papillomas and squamous cell carcinoma. This is the fifth report of an association between HPV 11 and malignant transformation of pulmonary papillomas (3, 4, 6, 7). Together, these five cases suggest a stereotypical clinical setting for the emergence of invasive carcinoma from RRP. CASE REPORTThe patient was a 23-year-old white man with a history of RRP, initially diagnosed at age 5. By age 10, he had developed laryngeal, tracheal, and pulmonary ...

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Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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“…RRP is a squamous lesion within the respiratory tract which in the majority of cases is caused by HPV6 and 11 at a prevalence rate varying between 50 and 90% (Gissmann et al, 1983;Major et al, 2005). The reported variation in prevalence rate of HPV can be attributed to differences between detection methods, sensitivity and types of samples.…”

Section: Discussionmentioning

confidence: 99%

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

Chansaenroj

Theamboonlers²,

Junyangdikul³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The prevalence of human papillomavirus genotypes differs in various target organs. HPV16 is the most prevalent genotype in the cervix while genotypes 6 and 11 are highly prevalent in skin and aero-digestive tract infections. In this study HPV11 positive specimens were selected from cervix, larynx and lung biopsy tissue to analyze the whole genome by PCR and direct sequencing. Five HPV11 whole genomes were characterized, consisting of two cervical specimens, two laryngeal specimens and one lung specimen. The results showed high homology of HPV11 in these organs. Phylogenetic analysis showed that all HPV11 derived from various organs belonged to the same lineage. Molecular characterization and functional studies can further our understanding of virulence, expression or transmission. Additional studies on functional protein expression at different organ sites will also contribute to our knowledge of HPV infection in various organs.

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“…These include HPV-6, HPV-11, HPV-16 and HPV-18 which have been associated with tumours of the genital tract. HPV-6 and HPV-11 DNAs have been identified in benign lesions whereas HPV-16 and HPV-18 DNAs have been found in malignant lesions (Gissmann et al, 1983;Ikenberg et al, 1983;Boshart et al, 1984;Crum et al, 1984). DNAs are also present in a number of cell lines derived from human cervical carcinomas, and in addition these DNAs are transcribed (Schwarz et al, 1985 ;Yee et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

The Expression of Human Papillomavirus Type 18 E6 Protein in Bacteria and the Production of Anti-E6 Antibodies

Matlashewski¹,

Banks²,

Wu-Liao³

et al. 1986

Journal of General Virology

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SUMMARYHuman papiUomavirus type 18 (HPV-18) has recently been closely linked with human malignant cervical lesions. The early region of the genome of the related bovine papillomavirus (BPV) has been shown to be important for the production of the transformed phenotype. BPV E6 has been shown to be a transforming protein. We report the primary structure of the HPV-18 E6 open reading frame and its predicted amino acid sequence. Both E6 protein and E6-fl-galactosidase fusion protein were synthesized in bacteria. Antisera were raised against the E6-fl-galactosidase fusion protein and against an E6 N-terminal peptide which was 14 amino acids long. We show that these antisera reacted on Western blots against E6 synthesized in bacteria. The HPV E6 antigen and antibodies described here will be useful in understanding HPV expression and its association with human malignancies and may also be diagnostically useful.

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Human papillomavirus types 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers.

Cited by 767 publications

References 12 publications

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Whole Genome Analysis of Human Papillomavirus Genotype 11 from Cervix, Larynx and Lung

The Expression of Human Papillomavirus Type 18 E6 Protein in Bacteria and the Production of Anti-E6 Antibodies

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