Human genital tumors as well as recurrent laryngeal papillomas were analyzed for the presence of human papil, lomavirus (HPV)6 and HPV 11 sequences. HPV 11 DNA was found in 7 of 14 laryngeal papillomas; in the 7 other tumors no HPV DNA was demonstrated. HPV 11 DNA was also found in all five atypical condylomata of the cervix included in this study. Condylomata acuminata mainly contained HPV 6 DNA. From 63 biopsy specimens, 41 clearly harbored HPV 6 DNA and 13 harbored HPV 11 DNA. In three tumors accurate typing was impossible, and in six additional ones neither HPV 6 nor .HPV 11 DNA could be demonstrated. The data support a genital origin of laryngeal papillomavirus infections. In 4 of 24 malignant tumors, HPV 11 DNA or related sequences were demonstrated; 2 of the 4 were biopsy specimens from invasive cancer, and the other 2 originated from carcinomata in situ. A possible role of this or related papillomavirus types in the induction of malignant genital. tumors remains to be elucidated.

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Serial colposkopic and cytologic observations of a 38-year-old patient in her first pregnancy show the development of a dysplasia from papilloma of the cervix within 6 months. Papilloma virus must be regarded as an infectious oncogenous agent in the region of the human cervix.

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