Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Haręża, Daria A.; Wilczyński, Jacek R.; Paradowska, Edyta

doi:10.3390/ijms23031818

Cited by 55 publications

(46 citation statements)

References 250 publications

(377 reference statements)

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“…Despite residual variability, these loops have a consistent three-dimensional structure within HPVs [ 1 , 35 , 37 ]. In the highly conserved regions of identical HPV types, the latter plays the same roles as the former, including membrane receptor binding and L1-L1 and L1-L2 interactions [ 1 , 38 ].…”

Section: The Molecular Pathogenesis Of Hpv Infectionmentioning

confidence: 99%

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection

et al. 2022

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The human papillomavirus (HPV), commonly documented as the cause of warts, has gained much interest recently due to its possible links to several types of cancer. HPV infection is discussed in this review from multiple angles, including its virology, epidemiology, etiology, immunology, clinical symptoms, and treatment. Recent breakthroughs in molecular biology have led to the development of new methods for detecting and treating HPV in tissue. There is no cure for HPV, and although vaccines are available to prevent infection with the most common HPV viruses, their utilization is limited. Destruction and excision are the primary treatment modalities. This review sheds light on the epidemiology, molecular pathogenesis, the association of several other pathogens with HPV, the latest treatment strategies available to treat the same, and an overview of the progress made and the obstacles still to be overcome in the fight against HPV infection.

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Section: The Molecular Pathogenesis Of Hpv Infectionmentioning

confidence: 99%

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection

et al. 2022

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“…The genetic material consists of several open reading frames encoding proteins involved in viral DNA replication (E1 and E2), regulation of viral gene expression (E2), virion formation (E4), and cell immortalization and transformation (E5, E6, E7) for high-risk HPV only [ 9 , 10 ] ( Figure 1 ). The L1 and L2 open reading frames encode capsid proteins.…”

Section: Introductionmentioning

confidence: 99%

“…This leads to an overexpression of the two viral oncoproteins E6 and E7 which interfere with critical cell-cycle points, such as suppressive tumor protein p53 and retinoblastoma protein pRB. The action of E6 and E7 combined with that of E5 promotes cell immortalization and transformation [ 10 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Human Papillomaviruses in Adolescents: Knowledge, Attitudes, and Practices of Pharmacists Regarding Virus and Vaccination in France

Dufour

Carrouel

Deroanne

2023

Viruses

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Human papillomaviruses (HPVs) are responsible for one of the most common sexually transmitted diseases in the world, and their oncogenic role has been well demonstrated in genital, anal, and oropharyngeal areas. However, a certain distrust and a lack of knowledge about this vaccine are perceptible among French adolescents and their parents. Thus, health professionals and, more particularly, pharmacists appear to be key persons to promote HPV vaccination and restore confidence in the target population. The present study aims to assess the knowledge, attitudes, and practices regarding HPV vaccination among pharmacists, particularly in boys, following the 2019 recommendation to vaccinate them. The present study was designed as a cross-sectional, quantitative, and descriptive survey that was conducted from March to September 2021 among pharmacists in France. 215 complete questionnaires were collected. Gaps in knowledge were found, only 21.4% and 8.4% obtained a high level of knowledge related to, respectively, HPV and vaccination. Pharmacists were confident in the HPV vaccine (94.4%), found it safe and useful, and felt that the promotion of the vaccine was part of their role (94.0%). However, only a few have already advised it, which they justify due to a lack of opportunity and forgetfulness. Faced with this, training, computerized reminders, or supportive materials could be implemented to improve the advice and thus the vaccination coverage. Finally, 64.2% were in favor of a pharmacy-based vaccination program. In conclusion, pharmacists are interested in this vaccination and the role of promoter. However, they need the means to facilitate this mission: training, computer alerts, supportive materials such as flyers, and the implementation of vaccination in pharmacies.

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“…Although no effective HPV inhibitors have been developed, several compounds and targets have been analyzed. Most research on HPV-related cancer has focused on the oncoproteins-proteins encoded by HPV's oncogenes that are highly involved in the synthesis and regulation of tumor-associated proteins [22,23] -particularly E6 and E7. Due to their well-characterized activities and pathways, these proteins are critical oncoproteins that differentiate high-risk from low-risk variations [5,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking and Molecular Dynamics Simulation-Based Identification of Natural Inhibitors against Druggable Human Papilloma Virus Type 16 Target

et al. 2023

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The E5 protein is the smallest known oncoprotein linked to HPV 16 cancer development. In this study, we determined the potential of asarinin and thiazolo as an inhibitor of the E5 protein through molecular dynamics. The results showed that the binding site is unstable because of its hydrophobic nature and small size, causing considerable changes in the binding site for each of the 3 drugs examined. Except for asarinin, which still interacts with the first hydrophobic domain, they preserved their capacity to prevent endosomal acidification, hyper amplification of the EGFR pathway and contact with BAP31. It may inhibit E5-MHC I interaction. Thiazolo[3,2-a]benzymidazole-3(2H)-one,2-(2-fluorobenzylideno)-7,8-dimethyl (thiazolo) is expected to form more stable protein-ligand complexes than the other 2. However, the SASA, hydrogen bond and DCCM plots show that both compounds are equivalent to HPV 16 E5 protein. HIGHLIGHTS The smallest known oncoprotein associated with cancer development as a result of HPV 16 infection is the E5 protein The SASA, hydrogen bond, and DCCM plots, on the other hand, show that asarinin and thiazolo are equivalent to the HPV 16 E5 protein Thiazolo is predicted to produce more stable protein-ligand complexes than the others because of its unique molecular dynamic properties GRAPHICAL ABSTRACT

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Human Papillomaviruses as Infectious Agents in Gynecological Cancers. Oncogenic Properties of Viral Proteins

Cited by 55 publications

References 250 publications

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection

Exploring the Molecular Pathogenesis, Pathogen Association, and Therapeutic Strategies against HPV Infection

Human Papillomaviruses in Adolescents: Knowledge, Attitudes, and Practices of Pharmacists Regarding Virus and Vaccination in France

Molecular Docking and Molecular Dynamics Simulation-Based Identification of Natural Inhibitors against Druggable Human Papilloma Virus Type 16 Target

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