Human Parvovirus B19 Associated With Idiopathic Thrombocytopenic Purpura

Aktepe, Orhan Cem; Yetgin, Sevgi; Olcay, Lale; Özbek, Namık

doi:10.1080/08880010490457141

Cited by 29 publications

(18 citation statements)

References 25 publications

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“…ITP association with PV-B19 infection was reported by Murray et al in 1994 [75]. In a study in our clinic of 19 children with ITP (8 acute, 11 chronic), the rate of 47% PV-B19 DNA also indicated a strong association of PV-B19 infection with ITP [78]. This relation was also supported by high seropositivity of anti-PV-B19 IgM and IgG.…”

Section: Pv-b19 Infection With Other Hematological Disorderssupporting

confidence: 65%

Untitled

2010

Turk J Hematol

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Parvovirus-B19 (PV-B19) is a member of Parvoviridae, which is one of the smallest DNA viruses. PV-B19-associated diseases usually serve as a good representation of the balance of virus, host response and the immune system. The diseases manifested with PV-B19 are erythema infectiosum, which is common in children, hydrops fetalis, transient pure red cell aplasia in patients with chronic hemolytic anemia, arthralgia -mostly observed in women, and chronic pure red cell aplasia in immunocompromised individuals. Cytopenia (bicytopenia, monocytopenia or pancytopenia) may also accompany the diseases mentioned above. On the other hand, there are many diseases, including neurologic, vasculitic, hepatic, rheumatoid, nephritic, autoimmune, myocardial, and others in which the mechanisms of the diseases are not clear, which may be associated with PV-B19. The virus may manifest with unexpected and unexplained clinical pictures and lead to misdiagnosis. Therefore, hematologic disorders in any unestablished clinical diagnosis should be investigated for PV-B19 infection. However, serologic examination for PV-B19 diagnosis is not sufficient in immunocompromised status. The virus can be determined with polymerase chain reaction (PCR) in the serum or tissue samples. Supportive therapy, blood transfusion and immunoglobulin are the conventional therapeutic interventions for PV-B19 today. Vaccination studies are under examination. (Turk J Hematol 2010; 27: 224-33) Key words: Children, hematologic findings, parvovirus, treatment

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Section: Pv-b19 Infection With Other Hematological Disorderssupporting

confidence: 65%

Untitled

2010

Turk J Hematol

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“…However, parvovirus associated thrombocytopenia has been reported in the literature. Some studies suggest that viral nonstructural-1 proteins, which are cytotoxic to megakaryocytes, are responsible for thrombocytopenia [3,4]. In addition, P antigen was found on the megakaryocyte and it supported the cytotoxic effects of parvovirus B19 on the megakaryocyte [6].…”

Section: Discussionmentioning

confidence: 91%

“…In addition some hematologic disorders may be seen as a complication. Although parvovirus B19 targets the erythroid progenitor cells, virus associated leukopenia, neutropenia, and thrombocytopenia have been reported in the literature [3][4][5][6]. Here, we report a case with petechia-purpuric rash and low leukocyte and thrombocyte count due to parvovirus B19 infection.…”

Section: Introductionmentioning

confidence: 88%

Petechial-Purpuric Rash, Leukopenia and Thrombocytopenia Associated Parvovirus B19

Kara¹,

Özdemir²,

Çıftçı³

et al. 2016

Ann Clin Anal Med

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ÖzetParvovirus B19 makülopapüler, eritemli, peteşiyal veya purpurik lezyonlar gibi farklı deri döküntüleri neden olabilir. Ayrıca parvovirüsü B19 aplastik anemi, löko-peni, nötropeni ve trombositopeni gibi bazı önemli hematolojik bozukluklara neden olabilir. Biz peteşiyal-purpurik döküntüleri ile hastaneye başvuran bir çocuk olguyu sunduk. Laboratuvar analizinde lökopeni ve trombositopeni bulundu ve parvovirus B19 IgM serolojik testleri pozitif olduğu tespit edildi. Yatışının üçüncü gününden sonra, peteşiyal-purpurik döküntüleri gerilemeye başladı ve laboratuvar sonuçları normal aralığa geldi. Biz hastalığın parvovirus B19 enfeksiyonu olduğunu düşünü-yoruz. Hastaya yanlızca ateş düşürücü ilaçlar verildi. Takibinde klinik ve laboratuvar bulguları tamamen iyileşti. Sonuç olarak; parvovirüs B19 peteşi ve purpura gibi bazı farklı klinik belirtiler neden olabilir. Ayrıca hematolojik bozukluklar da komplikasyon olarak görülebilir. Bu nedenle, döküntü, trombositopeni ve lökopenisi olan hastaların ayırıcı tanısında mutlaka düşünülmelidir. Anahtar KelimelerLökopeni; Parvovirüs B19; Döküntü; Trombositopeni Abstract Parvovirus B19 can cause different skin rashes like maculopapular, erythematous, petechial, or purpuric lesions. In addition, parvovirus B19 can cause some important hematologic disorders like aplastic anemia, leukopenia, neutropenia, and thrombocytopenia. We report a child who was admitted to the hospital with petechial-purpuric rashes. On laboratory analysis, leukopenia and thrombocytopenia were found and serologic testing of parvovirus B19 IgM was determined to be positive. After the third day of hospitalization, the petechial-purpuric rashes began to decline and laboratory results were in the normal range. We think that the disease was parvovirus B19 infection. The patient was treated with only antipyretic drugs. On follow up, the clinical and laboratory findings had completely returned to normal. In conclusion, parvovirus B19 can cause clinical signs such as petechiae and purpura. Also, hematologic disorders may be a complication. Because of this, it should be considered in the differential diagnosis in patients with rash, thrombocytopenia, and leukopenia.

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“…I have read the interesting report by Dr. Atkepe et al related to human parvovirus B19 (PVB19) associated with idiopathic thrombocytopenic purpura (ITP) in 19 patients [1]. They found parvovirus B19-specific IgM and IgG antibodies 57 and 73% of the patients, but viral genome was detected in the sera of only 9 (47%) of the 19 patients.…”

mentioning

confidence: 93%

Letter to the Editor: HUMAN PARVOVIRUS B19 ASSOCIATED WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

Sipahi¹

2005

Pediatric Hematology and Oncology

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Human Parvovirus B19 Associated With Idiopathic Thrombocytopenic Purpura

Cited by 29 publications

References 25 publications

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Petechial-Purpuric Rash, Leukopenia and Thrombocytopenia Associated Parvovirus B19

Letter to the Editor: HUMAN PARVOVIRUS B19 ASSOCIATED WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

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