Human parvovirus B19 infection in children with new onset Type 1 diabetes mellitus

O'Bryan, TA; Beck, Michael; Demers, Laurence M.; Naides, Stanley J.

doi:10.1111/j.1464-5491.2005.01708.x

Cited by 11 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Serum levels of B19 IgM and antibodies to the diabetic autoantigen IA-2 were significantly elevated. The authors noted homology in amino acid sequences between B19 and the extracellular domain of IA-2 [88,113]. Munakata et al described the case of a 40-year-old Japanese woman, in which three autoimmune diseases occurred after acute parvovirus B19 infection: rheumatoid arthritis, T1D and Graves'disease [106].…”

Section: Parvovirus B19mentioning

confidence: 99%

Viruses and Type 1 Diabetes: Focus on the Enteroviruses

Hober¹,

Sané²,

Riedweg³

et al. 2013

Type 1 Diabetes

View full text Add to dashboard Cite

Interestingly, viruses have been reported to be associated with T1D occurrence in animals. Experimental animal models, as BioBreeding (BB)-rat, nonobese diabetic (NOD) mouse or specific transgenic mouse strains, were used to investigate the mechanism by which viruses can modulate diabetogenesis. Viruses and human type 1 diabetes RubellaSeveral reports have shown that congenital rubella was associated with induction of islet autoantibodies in 10% to 20% of cases of congenital rubella, within 5 to 25 years [18,56,71].

show abstract

Section: Parvovirus B19mentioning

confidence: 99%

Viruses and Type 1 Diabetes: Focus on the Enteroviruses

Hober¹,

Sané²,

Riedweg³

et al. 2013

Type 1 Diabetes

View full text Add to dashboard Cite

show abstract

“…HT [130], RA [131,132], T1D [132,133], GD [132], MS [134], MG [135] Rotavirus Reoviridae Infection of the gastrointestinal tract T1D [136] respectively. KIR/HLA-C interactions can be altered by peptide loading and presentation by HLA-C [79,80], which could suggest that interaction seen in GD and MS of the associated HLA-C molecules with a given autoantigen/s could be affecting KIR binding and that this interaction between KIRs and HLA-C could play a role in autoimmune onset [81,82].…”

Section: John Cunningham (Jc) Virus Polymaviridaementioning

confidence: 99%

The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action

Gough

Simmonds²

2007

401

172

View full text Add to dashboard Cite

Abstract:The HLA region encodes several molecules that play key roles in the immune system. Strong association between the HLA region and autoimmune disease (AID) has been established for over fifty years. Association of components of the HLA class II encoded HLA-DRB1-DQA1-DQB1 haplotype has been detected with several AIDs, including rheumatoid arthritis, type 1 diabetes and Graves' disease. Molecules encoded by this region play a key role in exogenous antigen presentation to CD4+ Th cells, indicating the importance of this pathway in AID initiation and progression. Although other components of the HLA class I and III regions have also been investigated for association with AID, apart from the association of HLA-B*27 with ankylosing spondylitis, it has been difficult to determine additional susceptibility loci independent of the strong linkage disequilibrium (LD) with the HLA class II genes. Recent advances in the statistical analysis of LD and the recruitment of large AID datasets have allowed investigation of the HLA class I and III regions to be re-visited. Association of the HLA class I region, independent of known HLA class II effects, has now been detected for several AIDs, including strong association of HLA-B with type 1 diabetes and HLA-C with multiple sclerosis and Graves' disease. These results provide further evidence of a possible role for bacterial or viral infection and CD8+ T cells in AID onset. The advances being made in determining the primary associations within the HLA region and AIDs will not only increase our understanding of the mechanisms behind disease pathogenesis but may also aid in the development of novel therapeutic targets in the future.

show abstract

“…Also Sun and Zhang also reported hepatic dysfunction in an adult due to parvovirus (14). O'Brayan et al found no association between parvovirus B19 and T1DM development in childhood (15). In this case, acute hepatitis was complicated with DKA.…”

Section: Discussionmentioning

confidence: 60%