Human placental extract reduces allergic inflammation in a murine allergic rhinitis model

Kim, Boo‐Young; Park, Hyang Rim; Shin, Ji-Hyeon; Kim, Sung Won; Kim, Soo Whan

doi:10.1002/lary.24714

Cited by 12 publications

(12 citation statements)

References 23 publications

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“…Allergic rhinitis markedly affects patients' quality of life, and it is a major reason for outpatient visits to otolaryngology clinics [1][2][3][4][5]. Allergic rhinitis is generally thought to be mediated by Th2, with interleukin (IL)-4, IL-5, and IL-13 also contributing to its pathogenesis [6].…”

Section: Introductionmentioning

confidence: 99%

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Lee

Bae

Kim

et al. 2020

Clin Exp Otorhinolaryngol

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Objectives. Limited information is available regarding strain-related differences in mouse models of allergic rhinitis induced by Dermatophagoides farinae (Der f1). In this study, we compared differences between two mouse strains and determined the optimal dose of Der f1 for allergic rhinitis mouse models.Methods. Forty-eight mice were assigned to the following six groups (n=8 per group): group A (control, BALB/c), group B (Der f1-sensitized BALB/c, 25 µg), group C (Der f1-sensitized BALB/c, 100 µg), group D (control, C57BL/6), group E (Der f1-sensitized C57BL/6, 25 µg), and group F (Der f1-sensitized C57BL/6, 100 µg). Allergic inflammation was induced with Der f1 and alum sensitization, followed by an intranasal challenge with Der f1. Rubbing and sneezing scores, eosinophil and neutrophil infiltration, and immunoglobulin, cytokine, and chemokine levels in the nasal mucosa and from splenocyte cultures were assessed.Results. Rubbing and sneezing scores were higher in groups B, C, E, and F than in groups A and D, with a similar pattern in both strains (i.e., group B vs. E and group C vs. F). Serum immunoglobulin levels were significantly elevated compared to the control in groups B and C, but not in groups E and F. Eosinophil and neutrophil infiltration increased (all P<0.05) after the Der f1 challenge (groups B, C, E, and F) compared to the control (groups A and D) in both the BALB/c and C57BL/6 strains, without any significant difference between the two strains (group A vs. D, group B vs. E, and group C vs. F) (P>0.05). BALB/c mice (group B) showed a greater elevation of splenic interleukin (IL)-4 (P<0.01), IL-5 (P<0.01), and IL-6 levels (P<0.05) and nasal IL-4 mRNA levels (P<0.001) than the C57BL/6 mice (group E). Interestingly, mice treated with 100 µg Der f1 showed a weaker allergic response than those treated with 25 µg.Conclusion. We found 25 µg to be a more appropriate dose for Der f1 sensitization. BALB/c mice are more biased toward a Th2 response and are a more suitable model for allergic rhinitis than C57BL/6 mice. This study provides information on the appropriate choice of a mouse model for allergic rhinitis.

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Section: Introductionmentioning

confidence: 99%

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Lee

Bae

Kim

et al. 2020

Clin Exp Otorhinolaryngol

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“…It also can modulate maternal immune responses and contain various biologically active components, such as a variety of regulatory peptides, hormones, growth factors and cytokines [1]. Placental extract has been widely used in traditional medicine for wound healing and as an anti-inflammatory agent [2,3]. Moreover, the human placental extract has been used to treat liver disease for more than 40 years [4].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Sheep Placental Extract on Concanavalin A-induced Liver Injury in Mice

Luo

Yang³

et al. 2018

Molecules

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Though the biological effects of human placental extract have been widely studied, it has limited availability and its use poses ethical problems. Thus, domestic animal placental extracts are suggested as alternatives. In this study, the protective effect of sheep placental extract (SPE) on concanavalin A (Con A)-induced liver injury was investigated. BALB/c mice were randomly divided into six groups, including one normal group and five experimental groups, which received different oral doses of SPE (0, 5, 10 and 50 mg/kg) or a mixture of amino acids for 3 days before Con A injection. Compared with Con A-induced model group, the SPE administration significantly decreased serum aminotransaminase activity, alleviated pathological changes, recovered liver antioxidant capacity and prevented the increase of nitric oxide. Secretion of pro-inflammatory cytokines in serum decreased and mRNA expression of hepatic intercellular adhesion molecule-1, interferon-inducible chemokine 10 and inducible nitric oxide synthase were downregulated, while B-cell lymphoma-2 expression increased. The administration of amino acids mixture had no significant effect in most measurements compared with the model group, which indicated proteins and peptides, rather than individual amino acid, were largely responsible for the bioactivity of SPE. The results indicate SPE has potential therapeutic effects against immune-mediated hepatitis.

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“…The medical agents administered in acupuncture points are thought to play a synergistic effect with acupuncture point stimulation, and this method is believed to have a more sustained effect than the traditional acupuncture needling or simple intramuscular injection [24]. We speculate that anti-inflammation [25,26], anti-insomnia [27,28], and anti-fatigue [29,30] of placental extract might afford a sound basis for the reduction of pain, decrease of sleep disorder, and increase of productive time in this study. Increase of productive time which covers spending times for daily physical activities without sensation of fatigue and pain-evoked rest implies that patients with FMS manage their daily life more productively after successive APIs with placental extract.…”

Section: Discussionmentioning

confidence: 72%

Acupuncture point injection with placental extract improves pain and quality of life in patients with fibromyalgia syndrome

Park¹,

Cho²

2020

Physiother Res Rep

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Context: Fibromyalgia syndrome (FMS) can seriously affect the quality of patient lives due to chronic widespread pain. One of treatment strategies for the management of FMS is complementary and alternative medicine (CAM) treatments including acupuncture. A new acupuncture therapy, acupuncture point injection (API) that combines acupuncture and medication is recently used in China and Korea to accomplish more effective therapeutic outcomes. Yet, there is no attempt to investigate the effect of API with placental extract on the treatment of FMS.Objective: This study evaluated the effectiveness of API with placental extract on pain reduction and life quality in patients with FMS.Methods: This is a retrospective study analyzing medical records.Setting: Clinical setting.Participants: Participants were 64 patients at the clinic being treated for FMS, at an average age of 46 having symptom duration from 6 months to 2 years. Intervention: Placental extract was weekly injected into acupuncture points GB21, SI11, SI13, SI14, Ex-HN15, and BL13 for five weeks to the participants. Outcome measures:The primary outcome, pain, was measured on a VAS scale. Secondary outcomes, sleep disorder and daily workable hours without break, were evaluated using questionnaire.Results: After APIs with placental extract for five weeks, pain and sleep discomfort were substantially decreased. Patients also displayed elongated productive times which denote workable hours to maintain daily activity without pain-evoked break after the API treatment. Conclusion:We suggest that API with placental extracts is a safe and promising treatment for FMS. A larger follow-up trial is needed to determine more definitely the efficacy of API with placental extract.

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Human placental extract reduces allergic inflammation in a murine allergic rhinitis model

Abstract: Both prophylactic and therapeutic treatments with HPE significantly reduced allergic inflammation in nasal mucosa and had the potential to induce regulatory T cells in a murine model of AR.

Cited by 12 publications

References 23 publications

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis

The Protective Effect of Sheep Placental Extract on Concanavalin A-induced Liver Injury in Mice

Acupuncture point injection with placental extract improves pain and quality of life in patients with fibromyalgia syndrome

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