Human Plasma Levels of Vitamin E and Carotenoids Are Associated with Genetic Polymorphisms in Genes Involved in Lipid Metabolism , ,3

Borel, Patrick; Moussa, Myriam; Reboul, Emmanuelle; Lyan, Bernard; Defoort, Catherine; Vincent-Baudry, Stéphanie; Maillot, Matthieu; Gastaldi, Marguerite; Darmon, Michel; Portugal, Henri; Planells, Richard; Lairon, Denis

doi:10.1093/jn/137.12.2653

Cited by 152 publications

(137 citation statements)

References 32 publications

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“…Vitamin E metabolism protein (i.e., A395V, G402S, R417W, and G434R) showed lower transport efficiencies for both cholesterol and α-TOH [216] . Borel et al [217] analyzed polymorphisms in genes involved in lipid metabolism, namely APOA4, APOB, APOE, LPL and SRBI, and found α-or γ-TOH levels to be different in subjects with SNPs in APO4, APOE and SRBI or APO4 and SRBI, respectively. Major et al [218] found three SNPs to be associated with circulating α-TOH serum levels, rs964184 near APOA1, APOA4, APOA5 and APOC3, rs2108622 in CYP4F2 as well as rs11057830 in SCARB1.…”

Section: Genetic Polymorphismsmentioning

confidence: 99%

Complexity of vitamin E metabolism

Schmölz¹,

Birringer²,

Lorkowski³

et al. 2016

WJBC

183

138

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Bioavailability of vitamin E is influenced by several factors, most are highlighted in this review. While gender, age and genetic constitution influence vitamin E bioavailability but cannot be modified, life-style and intake of vitamin E can be. Numerous factors must be taken into account however, i.e. , when vitamin E is orally administrated, the food matrix may contain competing nutrients. The complex metabolic processes comprise intestinal absorption, vascular transport, hepatic sorting by intracellular binding proteins, such as the significant α-tocopherol-transfer protein, and hepatic metabolism. The coordinated changes involved in the hepatic metabolism of vitamin E provide an effective physiological pathway to protect tissues against the excessive accumulation of, in particular, non-α-tocopherol forms. Metabolism of vitamin E begins with one cycle of CYP4F2/CYP3A4-dependent ω-hydroxylation followed by five cycles of subsequent β-oxidation, and forms the water-soluble end-product carboxyethylhydroxychroman. All known hepatic metabolites can be conjugated and are excreted, depending on the length of their sidechain, either via urine or feces. The physiological handling of vitamin E underlies kinetics which vary between the different vitamin E forms. Here, saturation of the side-chain and also substitution of the chromanol ring system are important. Most of the metabolic reactions and processes that are involved with vitamin E are also shared by other fat soluble vitamins. Influencing interactions with other nutrients such as vitamin K or pharmaceuticals are also covered by this review. All these processes modulate the formation of vitamin E metabolites and their concentrations in tissues and body fluids. Differences in metabolism might be responsible for the discrepancies that have been observed in studies performed in vivo and in vitro using vitamin E as a REVIEW

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Section: Genetic Polymorphismsmentioning

confidence: 99%

Complexity of vitamin E metabolism

Schmölz¹,

Birringer²,

Lorkowski³

et al. 2016

WJBC

183

138

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“…At entry (n 212) and at the end of the 3-month period (n 169), biochemical analyses were performed as previously described (10,11) . For polymorphism detection, genomic DNA were prepared from white blood cells isolated from whole blood samples by a standard proteinase K-phenol method as reported (12,13) . The polymorphisms were genotyped by a PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) assay.…”

Section: Snp-diet Interactions In the Medi-rivage Studymentioning

confidence: 99%

Nutrigenetics: links between genetic background and response to Mediterranean-type diets

Lairon

Defoort

Martin

et al. 2009

Public Health Nutr.

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Objective: It has been substantiated that the onset of most major diseases (CVD, diabetes, obesity, cancers, etc.) is modulated by the interaction between genetic traits (susceptibility) and environmental factors, especially diet. We aim to report more specific observations relating the effects of Mediterranean-type diets on cardiovascular risk factors and the genetic background of subjects. Results and conclusions: In the first part, general concepts about nutrigenetics are briefly presented. Human genome has, overall, only marginally changed since its origin but it is thought that minor changes (polymorphisms) of common genes that occurred during evolution are now widespread in human populations, and can alter metabolic pathways and response to diets.In the second part, we report the data obtained during the Medi-RIVAGE intervention study performed in the South-East of France. Data obtained in 169 subjects at moderate cardiovascular risk after a 3-month dietary intervention indicate that some of the twenty-three single nucleotide polymorphisms (SNP) studied exhibit interactions with diets regarding changes of particular parameters after 3-month regimens. Detailed examples are presented, such as interactions between SNP in genes coding for microsomial transfer protein (MTTP) or intestinal fatty acid binding protein (FABP2) and triglyceride, LDL-cholesterol or Framigham score lowering in responses to Mediterranean-type diets.The data provided add further evidence of the interaction between particular SNP and metabolic responses to diets. Finally, improvement in dietary recommendations by taking into account known genetic variability has been discussed.

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“…[17][18][19][20][21][22][23][24] Scavenger receptor class B type 1 (SR-B1) might be a major receptor in the facilitated diffusion in Caco-2 cells, considering the results of studies using their antibodies and siRNAs. 22,25) In SR-B1 knockout mice, the efficiency of -carotene absorption was remarkably reduced, though not fully inhibited.…”

mentioning

confidence: 99%