Human plasma triglyceride labeling after high sucrose feeding. II. Study on triglyceride kinetics and postheparin lipolytic activity

Wu, Ching-Hui

doi:10.1016/0026-0495(75)90043-8

Cited by 4 publications

(5 citation statements)

References 25 publications

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“…Very high sucrose intakes (exceeding 30% energy) were associated with elevations in plasma TG and/or VLDL in most studies (Nestel et al, 1970; Anderson et al, 1973; Naismith et al, 1974; Wu and Shreeve, 1975; Reiser et al, 1979a; Hayford et al, 1979; Albrink and Ullrich, 1986; Yudkin et al, 1986). However, two studies in women showed no effect (Behall et al, 1980; Surwit et al, 1997).…”

Section: Discussionmentioning

confidence: 89%

“…Using slightly lower levels of total carbohydrate, Wu et al also found significantly raised TG (+12.6%) and VLDL-TG (+22%) among 17 overweight subjects fed a high sucrose diet (45%) compared with 5% sucrose for 10–14 days, although there was no effect on cholesterol (Wu and Shreeve, 1975). By contrast, among 23 free-living healthy young men consuming a high sucrose diet (39% or 300 g sucrose) for 14 days and then returning to their normal diet for another 14 days (13% sucrose or 105 g), there were significant increases in total cholesterol (TC) (8%), TG (13%), and phospholipids (10%) on the sucrose diet (all p < 0.01), which returned to baseline on resumption of the normal diet (Naismith et al, 1974).…”

Section: Resultsmentioning

confidence: 98%

“…However, in a number of studies subjects had elevated blood lipids at the start of the study (Dunnigan et al, 1970; Nestel et al, 1970; Mann et al, 1972; Wu and Shreeve, 1975; Reiser et al, 1979a, 1979b, 1980; Behall et al, 1980), were overweight or obese (Nestel et al, 1970; Wu and Shreeve, 1975; Behall et al, 1980; Black et al, 2006), or were moderately insulin resistant (Black et al, 2006). Hence, whether the conclusions of this review are indeed applicable to the “normal” disease-free population of young- and middle-aged adults with a range of body weights is debatable.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence for TC and LDL were similarly conflicting: 4 studies using > 30% sucrose suggested adverse effects (Naismith et al, 1974; Reiser et al, 1979a, b; Albrink and Ullrich, 1986; Yudkin et al, 1986), while 3 did not (Wu and Shreeve, 1975; Behall et al, 1980; Surwit et al, 1997). More moderate levels of sucrose (< 30%) were associated with small effects on cholesterol in 5 studies (Roberts, 1973; Lock et al, 1980; Fraser et al, 1981; Marckmann et al, 2000; Black et al, 2006) but not in 7 others (Dunnigan et al, 1970; Mann and Truswell, 1972; Grande et al, 1974; Bossetti et al, 1984; Albrink and Ullrich, 1986; Brynes et al, 2003; Aeberli et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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The Effects of Sucrose on Metabolic Health: A Systematic Review of Human Intervention Studies in Healthy Adults

Gibson¹,

Gunn²,

Wittekind³

et al. 2013

Critical Reviews in Food Science and Nutrition

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We systematically reviewed interventions substituting sucrose for other macronutrients in apparently healthy adults to assess impact on cardiometabolic risk indicators. Multiple databases were searched to January 2012 and abstracts assessed by 2 reviewers. Twenty-five studies (29 papers) met inclusion criteria but varied in quality and duration. Weaknesses included small subject numbers, unclear reporting of allocation, unusual dietary regimes, differences in energy intake, fat composition or fibre between conditions, unhealthy subjects, heterogeneity of results, and selective reporting. Insufficient data were available to draw reliable conclusions except with regard to the substitution of sucrose for starch, where effects on plasma lipids were inconsistent, mostly explicable by other factors, or nonsignificant. Based on fewer studies, there was little evidence for significant effects on plasma glucose or insulin. Sucrose substitution for starch up to 25% energy does not appear to have adverse effects on cardiometabolic risk indicators in apparently healthy adults. Furthermore, there is no consistent evidence that restricting sucrose in an isoenergetic diet would affect risk indicators, except perhaps in people with certain preexisting metabolic abnormalities. Larger, high-quality studies, lasting several months and studying a wider range of outcomes, are needed in order to provide evidence on which to base public health initiatives.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Effects of Sucrose on Metabolic Health: A Systematic Review of Human Intervention Studies in Healthy Adults

Gibson¹,

Gunn²,

Wittekind³

et al. 2013

Critical Reviews in Food Science and Nutrition

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show abstract

“…Carbohydrateinduced hyperlipemia has been found to be associated with an enhanced forma tion and secretion of lipoproteins from the liver in both species (32,34). The effect of dietary carbohydrates and fat on the properties of lipoproteins and lipid transport was studied in rats (7,10,12,24).…”

mentioning

confidence: 99%

Effects of Isocaloric Supplements of Glucose or Soyabean Oil on Lipids in Tissues and Plasma Lipoproteins of Starved and Overfed Chicks

Shapira¹,

Nachtomi²,

Nir³

1979

Ann Nutr Metab

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Chicks were overfed a basic diet supplemented isocalorically by soyabean oil or glucose 1, 2 and 10 days after 1 day of starvation. Carcass lipids resumed the prestarvation level 1 and 2 days after overfeeding with oil or glucose, respectively. After 10 days, an equal amount of lipid, mainly triglycerides, accumulated in the carcasses of both supplement groups. In the liver a transient accumulation of lipid was noticed in the oil-supplemented groups while a continuous increase was found in the glucose-supplemented ones. Hyperlipemia, due essentially to very low density lipoprotein (VLDL), was concomitant to liver lipid concentration. After 1 day, oil overfeeding raised plasma VLDL 6-fold, while the same level of VLDL was obtained within 2 days with glucose supplement. After 10 days, hyperlipemia was reduced in the oil-supplemented group, while it increased in the glucose-supplemented one. The fatty acid fluctuation caused by the treatments in liver lipids and plasma VLDL were grossly similar: the level of linoleic acid was reduced by glucose and increased by oil supplementation; the linoleic acid increase in VLDL preceeded that of liver lipids in the oil-supplemented groups. The results indicate a delayed transport of newly synthesized hepatic lipids in glucose-supplemented animals.

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Pharmacological studies on tiadenol in type IV patients Evidence for a mechanism of action different from other lipid-lowering drugs

et al. 1981

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Human plasma triglyceride labeling after high sucrose feeding. II. Study on triglyceride kinetics and postheparin lipolytic activity

Cited by 4 publications

References 25 publications

The Effects of Sucrose on Metabolic Health: A Systematic Review of Human Intervention Studies in Healthy Adults

The Effects of Sucrose on Metabolic Health: A Systematic Review of Human Intervention Studies in Healthy Adults

Effects of Isocaloric Supplements of Glucose or Soyabean Oil on Lipids in Tissues and Plasma Lipoproteins of Starved and Overfed Chicks

Pharmacological studies on tiadenol in type IV patients Evidence for a mechanism of action different from other lipid-lowering drugs

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