Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: An in vitro study

Güçlüer, Öznur; Akarsu, Esin; Yavuz, Emre; Er, Kürşat; Kuştarcı, Alper

doi:10.1016/j.chmed.2019.11.005

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…Al-Sabawi et al 24 investigated the antimicrobial properties of Salvador Persica ex-tract against anaerobic and aerobic bacteria recovered from teeth having necrotic pulps found significant antimicrobial effect with 15% alcoholic extract of Salvadora Persica and revealed no significant difference from sodium hypochlorite and chlorhexidine in respect to antimicrobial properties. Güçlüer et al 2 concluded in their investigation that S. mukorossi extracts shows ability to dissolve pulp tissue emphasize need of further testing to accomplish the creation of commercially available irrigant for clinical purpose and to enhance the efficacy of S. Mukorossi by blending it with other irrigation solutions.…”

Section: R E T R a C T E D Discussionmentioning

confidence: 99%

“…6 Even then these irrigants were found suitable for the removal of coronal third and middle third of SL but not significantly helpful for the apical third of the canal. 2,7 This creates a need for material with all the needful properties of an irrigant, with minimum harmful effects, and can be safely used in RCT. Therefore, natural phytochemical products are in discussion to be used as prospective RCT irrigant solutions.…”

Section: Introductionmentioning

confidence: 99%

“…The chemo-mechanical preparation can be done by irrigation and instrumentation of canal. 2 Instrumentation causes shaping and widening of canal space for complete removal of infected, necrotic and a portion of sound dentin to ensure microbes’ free canal. Irrigation also plays an important role to accomplish successful treatment.…”

Section: Introductionmentioning

confidence: 99%

“…6 Even then these irrigants were found suitable for the removal of coronal third and middle third of SL but not significantly helpful for the apical third of the canal. 2,7…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Comparative evaluation of Sapindus Mukorossi extract with 17% EDTA on smear layer removal in various parts of the tooth root

Farooq

Bilgrami

Faraz

et al. 2023

Journal of Applied Biomaterials & Functional Materials

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Objectives: This study aimed to compare the effectiveness of an experimental root canal irrigant and 17% Ethylene-di-amine tetra acetic acid for removal of the smear layer in the coronal, middle and apical portions of the root canal. Materials and methods: Ninety human single rooted maxillary and mandibular teeth were selected for this study. The teeth were randomly divided into two experimental groups and one control group as follows: Group A (Ethanolic extract of Sapindus Mukorossi), Group B (17% EDTA), and Group C (Distilled water). The root canals of all three groups were prepared with stainless steel K-files by means of the standard step-back technique and irrigated with 5.25% sodium hypo chloride. The teeth were decoronated, following the irrigation and divided longitudinally into two-halves and visualized using scanning electron microscope (SEM) for the amount of smear layer present utilizing the three-point score system. The observations were noted both before and after the treatment. Nonparametric tests were applied for the comparison and p-value ⩽ 0.05 was considered as statistically significant. Results: It was evident from that smear layer was completely removed in coronal portion of 27 out of 30 teeth in-group A. For middle and apical areas of group A, 24 and 19 teeth showed complete smear layer removal. In-group B it was found that there were 24, 21, and 3 teeth at coronal, middle and apical, areas respectively where smear layer were completely absent. Intra group comparison showed a significant difference ( p = 0.002) in smear layer removal was found for group A at coronal, middle and apical thirds. Similarly, a significant difference ( p = 0.001) was also found for group B; however heavy smear layer was found among the three parts of the canal for group C. Conclusions: Ethanolic extract of Sapindus Mukorossi have higher effectiveness in removing the smear layer from the root canal in comparison to 17% EDTA.

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Section: R E T R a C T E D Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…6 Even then these irrigants were found suitable for the removal of coronal third and middle third of SL but not significantly helpful for the apical third of the canal. 2,7…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

RETRACTED: Comparative evaluation of Sapindus Mukorossi extract with 17% EDTA on smear layer removal in various parts of the tooth root

Farooq

Bilgrami

Faraz

et al. 2023

Journal of Applied Biomaterials & Functional Materials

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“…While the study highlighted the significant pulp dissolving capacity of the SM extract, it was found to be inferior to NaOCl, consistent with the findings of the present study. Notably, the study did not assess dissolution capacity concerning different methods of activation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Dental Pulp Tissue Dissolution Ability of Sapindus mukorossi and Sodium Hypochlorite

Kaliamoorthy,

Rayar,

SundarRaj

et al. 2024

Cureus

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Background The Sapindus mukorossi (SM) extract has been reported to possess antibacterial, antifungal, anti-inflammatory, and antioxidant characteristics. However, there is limited research demonstrating the effectiveness of SM in dissolving dental pulp tissue. Methods In an in vitro investigation, pulp tissue samples were extracted from human teeth, collectively weighing 144 mg. These samples were divided equally and activated by manual digital agitation (MDA) or ultrasonic (US) irrigation for three 30-second cycles with a resting period of 45 seconds between each activation. The samples in each group were sub-categorized into a set of three groups based on the treatment received as normal saline (NS), 5.25% sodium hypochlorite (Hypo), or Sapindus mukorossi (SM). Statistical tests, including the student t-test and one-way analysis of variance (ANOVA), were employed to compare the mean weight differences among the groups, with a significance level set at p ≤ 0.05 for all comparisons. Results The one-way analysis of variance (ANOVA) and independent t-test revealed significant intergroup differences (p<0.05). Turkey’s post hoc analysis indicated significant distinctions, particularly when comparing Hypo with the other two irrigants, namely Hypo-NS (p<0.05) and Hypo-SM (p<0.05) when the MDA method was employed. Considering only the method adopted, the US technique was significantly superior (p=0.04) to the MDA. Conclusion Sapindus mukorossi (SM) demonstrated efficacy in dissolving pulp tissue but was not as effective as sodium hypochlorite (Hypo) which is the standard agent for root canal irrigation. SM to be used as an alternative to Hypo on clinical grounds needs further validation from research.

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Herbs and Their Applications as Root Canal Medicaments

Balagopal,

James,

Geethapriya

et al. 2023

Pharmacological Studies in Natural Oral Care

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Human pulp tissue dissolution ability of different extracts of Sapindus mukorossi: An in vitro study

Cited by 8 publications

References 31 publications

RETRACTED: Comparative evaluation of Sapindus Mukorossi extract with 17% EDTA on smear layer removal in various parts of the tooth root

RETRACTED: Comparative evaluation of Sapindus Mukorossi extract with 17% EDTA on smear layer removal in various parts of the tooth root

Comparative Evaluation of Dental Pulp Tissue Dissolution Ability of Sapindus mukorossi and Sodium Hypochlorite

Herbs and Their Applications as Root Canal Medicaments

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