The modern school system requires universities to solve a complex social problem connected with the preparation of teachers. The future specialist should be well-educated, understand the depth of connections between phenomena and processes, and have a holistic view of the world. Therefore, the future teacher as a specialist in the humanitarian field has to master the basics of various academic disciplines. The use of interdisciplinary integration of academic disciplines in the educational process of the university meets the stated goal. The interrelation and interaction of concepts, objects, phenomena, processes, the integration of various subject areas leads to the formation of a holistic picture of future professional activity. The purpose of the research is the theoretical substantiation and experimental verification of the use of interdisciplinary integration of educational disciplines in the formation of the future professional responsibility of the university teacher. The research methods are theoretical (analysis and synthesis of regulatory documents, study of psychological and pedagogical literature, content analysis of educational and methodical materials), and pedagogical experiment (stating, forming, control stages). The authors have developed a modular program which uses interdisciplinary integration of humanitarian and economic disciplines. The qualitative and quantitative analysis of the pedagogical experiment allows to state that the interdisciplinary integration of educational disciplines makes it possible to form a subject of responsibility, namely, it contributes to the formation of professional responsibility.