Human semen hyperviscosity: prevalence and effects on physical and biochemical semen parameters in subfertile Egyptian men

Mahran, Zakaria; Saleh, Mohammed El-Eraki

doi:10.4103/1110-6530.150276

Cited by 5 publications

(6 citation statements)

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“…In our study, there was a statistically significant increase in semen hyperviscosity in the leukocytospermia group when compared with the non leukocytospermia group. This finding is in accordance with most previous studies reporting seminal hyperviscosity in leukocytospermia with different techniques [21, 22, 23]. Semen hyperviscosity is mostly attributed to male accessory gland infection that commonly associates leukocytospermia with inflammation, as well as dysfunction of the sex glands or even the immune system [21].…”

Section: Discussionsupporting

confidence: 91%

Impact of leukocytospermia on sperm dynamic motility parameters, DNA and chromosomal integrity

Moubasher

Sayed

Mosaad

et al. 2018

Cent european J Urol

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IntroductionTo characterize sperm dynamic motility patterns and chromatin integrity in infertile men with leukocytospermia.Material and methodsFifty patients with primary infertility and oligoasthenoteratozoospermia included in this prospective, controlled, blind study. All patients underwent clinical evaluation, semen peroxidase stain, computer aided semen analysis (CASA), sperm DNA integrity evaluation with acridine orange test (AOT) and fluorescence in situ hybridization (FISH) analysis of 18, X and Y chromosomes. Pregnancy outcomes were documented following antibiotic treatment of patients with leukocytospermia.ResultsInfertile men with leukocytospermia had significantly lower progressive and total sperm motility percentages compared to the control group. Sperm dynamic motility parameters by CASA including curvilinear, straight line and average pathway velocities, straightness and amplitude of lateral head displacement were significantly lower in leukocytospermia. Sperm DNA fragmentation index was significantly higher in leukocytospermia. Percentages of sperm with disomy XY and 18 were significantly higher. These changes in sperm motility parameters and DNA integrity correlated with the number of peroxidase positive leukocytes. Follow-up of 23 of the 25 patients with leukocytospermia after antibiotic treatment revealed significantly higher pregnancy rates in cured patients than in those with persistent leukocytospermia.ConclusionsLeukocytospermia has a significant impact on sperm dynamic motility patterns, DNA and chromosomal integrity in infertile men which can adversely affect the likelihood of a successful pregnancy.

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Section: Discussionsupporting

confidence: 91%

Impact of leukocytospermia on sperm dynamic motility parameters, DNA and chromosomal integrity

Moubasher

Sayed

Mosaad

et al. 2018

Cent european J Urol

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“…The results of current study showed a nonsignificant decrease at (p<0.05) in sperm concentration, progressive motility and normal sperm morphology while a nonsignificant increase at (p<0.05) in leucocytes in group abnormal semen viscosity as compared with group normal semen viscosity. This study agrees with Mahran and Saleh (2014) showed no statistically significant differences in sperm concentration, total sperm count and normal sperm morphology in group abnormal semen viscosity as compared with group normal semen viscosity. but showed a significant decrease of sperm motility and indicated a significant positive correlation between leukocytospermia and hyperviscosity semen…”

Section: Study Of Semen Parameters In Infertile Men According To Type...supporting

confidence: 92%

“…▪ Semen Leukocytes evaluation Leukocytes were counted using the Leucoscreen method,Briefly, one drop of semen was mixed with one drop of working solution (Leucoscreen stain and hydrogen peroxide), covered with a cover slip for 2 min, and then the result was read at a magnification of ×400. Peroxidase-positive cells stained yellow to brown, whereas other cells stained pink (Mahran, and Saleh., 2014).…”

Section: Laboratory Evaluation ▪ Semen Collection and Evaluationmentioning

confidence: 99%

“…Semen is comprised of fluids released by the male accessory glands, which contain proteins necessary for its coagulation and liquification. The abnormal viscosity of seminal fluid caused by dysfunction of the prostate or seminal vesicles (Mahran, Z., and Saleh, 2014) is characterized by a thick and coagulated appearance (Issa Layali, et al,2015). It affects approximately 12 to 29 percent of male infertile individuals (Du Plessis et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Effect of type and severity of semen viscosity on sperm parameter, antisperm antibody, some cytokine and zinc levels for infertility men

Taqi

AL-Murshidi

2022

ijhs

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viscosity of semen is one of the important factors in the occurrence of fertilization. Increasing the viscosity leads to infertility because it affects the function of the sperm, it linked to a decrease in the movement of sperm, and thus prevents the passage of sperm through the female reproductive system naturally. The aim of this study was to assess the effect type (normal or abnormal) and severity of semen viscosity (mild, moderate, sever) on semen quality, antisperm antibody, some cytokines and zinc levels for infertile men. The study included of eighty-eight (88) semen samples from individuals that are in abstinence for 2-7 days where the study included 34 men had normal semen viscosity and 54 men had abnormal semen viscosity from Fertility Centre in Al-Sadder teaching hospital in Al-Najaf / Iraq during the period of (2/11/ 2021) and (5/2/2022). The results of current study showed a nonsignificant decrease at (p<0.05) in sperm parameters. while showed a nonsignificant increase at (p<0.05) in leucocytes in group abnormal semen viscosity as compared with group normal semen viscosity also in sever semen viscosity compared to moderate semen viscosity.

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“…Patients with higher seminal fluid viscosity have increased concentrations of leukocytes compared to patients with normal viscous semen. Mahran and colleagues reported an increase of leukocytes in 37.5% of infertile men with high seminal fluid viscosity [28]. Moreover, leukocytospermia correlates with a reduction of sperm motility and vitality in patients with hyperviscous seminal fluid [28].…”

Section: Seminal Fluid Hyperviscosity and Male Accessory Gland Infectmentioning

confidence: 98%

The Relationship between Seminal Fluid Hyperviscosity and Oxidative Stress: A Systematic Review

et al. 2021

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Introduction: Seminal fluid viscosity is a key parameter to achieve fertilization. Viscosity is more frequently increased in patients with infertility. However, the mechanism by which hyperviscosity causes infertility is still poorly understood. As an increased blood viscosity is associated with diseases caused by oxidative stress, it can be supposed that there is a relationship between seminal fluid viscosity and oxidative stress in male infertility. Therefore, this systematic review aims to investigate the relationship between hyperviscous seminal fluid and oxidative stress. Materials and methods: We performed a systematic search on the following databases Pubmed, MEDLINE, Cochrane, and Scopus from the earliest available date to 10 January 2021, using Medical Subjects Headings (MeSH) indexes and keywords searches. The study included all the articles that evaluated the relationship between increased seminal fluid viscosity and oxidative stress. Article reviews even though dealing with seminal fluid hyperviscosity were excluded. Results: 5 articles were included in this systematic review. The results demonstrated an important impairment of antioxidant systems and increased oxidative stress in patients with high seminal fluid viscosity. Conclusions: These findings suggest that a careful assessment of oxidative stress in patients with hyperviscosity may be very useful in clinical practice. Infertile patients with seminal fluid hyperviscosity could benefit from the treatment with antioxidants to protect sperm cells from oxidative damage and to improve their functional properties.

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Human semen hyperviscosity: prevalence and effects on physical and biochemical semen parameters in subfertile Egyptian men

Cited by 5 publications

References 0 publications

Impact of leukocytospermia on sperm dynamic motility parameters, DNA and chromosomal integrity

Impact of leukocytospermia on sperm dynamic motility parameters, DNA and chromosomal integrity

Effect of type and severity of semen viscosity on sperm parameter, antisperm antibody, some cytokine and zinc levels for infertility men

The Relationship between Seminal Fluid Hyperviscosity and Oxidative Stress: A Systematic Review

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