Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens

Jurewicz, Joanna; Radwan, Michał; Wielgomas, Bartosz; Dziewirska, Emila; Karwacka, Anetta; Klimowska, Anna; Kałużny, Paweł; Radwan, Paweł; Bochenek, M.; Hanke, Wojciech

doi:10.1097/jom.0000000000001106

Cited by 51 publications

(33 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have demonstrated that disorders of sex hormones result in male infertility. For instance, changes in FSH, LH, and T levels are associated with damage to the testes, impeding of spermatogenesis and maturation, and result in decreased sperm motility and activity, leading to infertility [43][44][45] . This finding also exhibits strong correlation with the change in microbiota.…”

Section: Discussionmentioning

confidence: 99%

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Human microbiota play an important role in the health of their human hosts. Recent studies have demonstrated that microbiota exist in seminal plasma. The current study aims to elucidate whether seminal microbiota exist in patients with different types of dysspermatism and whether bacterial biomarkers can be identified for them. A total of 159 study participants were recruited, including 22 patients with oligoasthenospermia, 58 patients with asthenospermia, 8 patients with azoospermia, 13 patients with oligospermia, and 58 matched healthy controls. Seminal microbiota composition was analyzed using 16S rRNA gene-based sequencing. The results showed that the composition of seminal microbiota of patients with dysspermatism differed from those of healthy controls. Comparison of the microbiota composition in semen samples from patients with different types of dysspermatism showed that microbiota in patients with asthenospermia and oligoasthenospermia were distinct from healthy controls in beta diversity (P < 0.05). Characteristic biomarkers, including Ureaplasma, Bacteroides, Anaerococcus, Finegoldia, Lactobacillus and Acinetobacter lwoffii, were identified based on LEfSe analysis. Inferred functional analysis based on seminal microbiome data further indicated the presence of potential pathogenic biomarkers in patients with asthenospermia and oligoasthenospermia. These results provided profiles of seminal microbiota exhibited in different types of dysspermatism, thus providing new insights into their pathogenesis. Human microbiota, with its diverse relationships-commensal, parasitic, mutualistic, and pathogenic-play an important role in human health. Recent studies have reported that microbiota exist in almost every part of human body-even in the endocrine niche, such as in tumors, blood, and synovial fluid 1-4. Advances in technology and new research have demonstrated that microbiota are found in seminal plasma, and play an important role in host homeostasis 5. It has been demonstrated that the presence of bacteria in sperm is associated with male infertility 6. Some bacteria in the urogenital tract may affect spermatogenesis and decrease sperm quality through various means, including decrease in sperm motility, deficiency in DNA integrity, and destruction of mitochondrial function 7. Escherichia coli, Mycoplasma genitalium, Ureaplasma urealyticum, Mycoplasma hominis, Staphylococcus aureus, and Chlamydia trachomatis are pathogens associated with male infertility 8-12. Several studies using high-throughput sequencing have demonstrated that seminal plasma has a bacterial community, which includes Lactobacillus, Pseudomonas, Prevotella, and Gardnerella, among others 13-19 .

show abstract

Section: Discussionmentioning

confidence: 99%

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Yang

Zhang

Xue

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Samples which concentration exceeded the highest point of calibration curve were reanalyzed using smaller volume of urine. The limit of detection for MP, EP and PP was 0.5 ng/ml and for iBuP and BP 1.0 ng/ml [20]. The within-and between-day imprecision was 20 and 8% for MP and EP and 5% for PP, iBuP and BP, respectively.…”

Section: Urinary Parabens Measurementsmentioning

confidence: 91%

Parameters of ovarian reserve in relation to urinary concentrations of parabens

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Parabens are synthetic chemicals commonly used in cosmetics, pharmaceuticals, food and beverage processing as antimicrobial preservatives. In experimental animals, parabens exposure was associated with adverse effects on female reproduction. Despite the widespread use of parabens little is known about their effect on female fecundity. The objective of the current analysis was to evaluate the associations of urinary parabens concentrations with parameters of ovarian reserve among women undergoing treatment in a fertility clinic. Methods: Five hundred eleven female aged 25-39 years who attended the infertility clinic in central region of Poland for diagnostic purposes were recruited between September 2014 and February 2019. Urinary concentrations of parabens were measured by a validated gas chromatograohy ion-tap mass spectrometry method. Parameters of ovarian reserve were: antral follicle count (AFC), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E 2 ) levels. Results: The geometric mean of specific gravity adjusted urinary concentrations of methyl (MP), ethyl (EP), propyl (PP), butyl (BP) and izobutyl paraben (iBuP) were 107.93 μg/L, 12.9 μg/L, 18.67 μg/L, 5.02 μg/L and 2.80 μg/L. Urinary concentrations of PP in the third quartile of exposure ((50-75] percentyl) were inversely associated with antral follicle count (p = 0.048), estradiol level (p = 0.03) and positively with FSH concentration (p = 0.026). MP, EP, BP and iBuP parabens were not associated any with parameters of ovarian reserve. Conclusions: Chronic exposure to PP may potentially contributing to reduced fecundity and impair fertility. As this is one of the first study to investigate the potential effect of parabens on ovarian reserve further epidemiological studies with longer duration of observation are needed.

show abstract

“…Parabens are extensively used as antimicrobial preservatives in food, cosmetics, toiletries and pharmaceuticals [29]. According to our knowledge only 3 studies examine the association between exposure to parabens and reproductive hormones in the case of men [17,30,31]. [38,39] indicated that there was an inverse association between urinary metabolites of non-persistent insecticides and reproductive hormones levels.…”

Section: Parabens and Male Reproductive Hormonesmentioning

confidence: 99%

“…Some authors [18,20,26] also revealed that exposure to phthalate was inversely associated with E 2 and free androgen index. Three studies [17,30,31] assess the relationship between exposure to parabens and male reproductive hormones levels and only in the study performed by Jurewicz et al [31] the level of urine BP was negatively associated with testosterone. Two of the studies [17,30] found no evidence for this association.…”

Section: Exposure Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Environmental non-persistent endocrine-disrupting chemicals exposure and reproductive hormones levels in adult men

Dziewirska¹,

Hanke²,

Jurewicz³

2018

Int J Occup Med Environ Health

Self Cite

View full text Add to dashboard Cite

Non-persistent endocrine-disrupting chemicals (EDCs) are exogenous, man-made substances present in the environment that may interfere with the natural human hormones and may exert adverse consequences on human organism. Endocrinedisrupting chemicals have been suspected to be associated with altered reproductive function in the case of males and females. Environmental endocrine-disrupting non-persistent chemicals like parabens, phthalates, bisphenol A (BPA), synthetic pyrethroids and organophosphate pesticides are found in various products such as metal food cans, plastic bottles, detergents, personal care products or chemicals used for fighting against insects. The widespread distribution of these chemicals causes that humans are permanently exposed through multiple sources. The aim of this review is to summarize data linking non-persistent endocrine-disrupting chemicals exposure, and human, male reproductive hormones levels. The included studies were selected by searched PubMed, Web of Science and MEDLINE, original papers published from 2006 to 2016 and referring to human data were included to the review. The results of reviewed studies were not consistent, however, majority of the studies indicated that non-persistent EDCs may affect male reproductive hormones levels. Most findings suggest that exposure to environmental EDCs is negatively related to the level of testosterone (except for exposure to BPA which is positively associated). In most of the studies negative association was found between exposure to examined EDCs and free androgen index, too. Considering the suggested health effect of exposure to EDCs, more epidemiological data is needed. Int J Occup Med Environ Health 2018;31(5):551-573.

show abstract

Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens

Abstract: This is one of the first study on this topic, so the observation of the relationship between parabens and semen quality warrants further investigation.

Cited by 51 publications

References 28 publications

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Potential Pathogenic Bacteria in Seminal Microbiota of Patients with Different Types of Dysspermatism

Parameters of ovarian reserve in relation to urinary concentrations of parabens

Environmental non-persistent endocrine-disrupting chemicals exposure and reproductive hormones levels in adult men

Contact Info

Product

Resources

About