Human serum albumin attenuates global cerebral ischemia/reperfusion-induced brain injury in a Wnt/β-Catenin/ROS signaling-dependent manner in rats

Tang, Yunping; Shen, Jie; Zhang, Feng; Fei-yu, Yang; Ming, Lei

doi:10.1016/j.biopha.2019.108871

Cited by 27 publications

(23 citation statements)

References 39 publications

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“…[22][23][24][25] Dysregulation of the Wnt/β-catenin signaling pathway has been widely accepted to influence the malignant process by affecting cell proliferation, cell apoptosis, the cell cycle, metastasis, stemness, drug resistance, and metabolic reprogramming. [26][27][28][29][30] Wnt ligands bind to Frizzled receptor complexes and activate Frizzled, stabilizing the cytoplasmic β-catenin protein by inhibiting the protein destruction complex (APC, axin, GSK3β, and CK1). Down-regulation of APC contributes to the nuclear accumulation of β-catenin, which subsequently interacts with a LEF/TCF transcription factor to activate the transcription of target genes, including apoptosis-and cell cycle-related proteins.…”

Section: Discussionmentioning

confidence: 99%

<p>KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt/β-Catenin Signaling Pathway</p>

Jiang

Zhang

et al. 2020

OTT

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KIAA1522 was previously identified to play a crucial role in cancer development and progression. However, its functions and underlying mechanisms in hepatocellular carcinoma (HCC) remain elusive. Materials and Methods: To elucidate the role of KIAA1522 in HCC, its expression was assessed using The Cancer Genome Atlas and GEPIA databases. Next, these results were validated by quantitative reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemistry of HCC tissues and cell lines. Flow cytometry, CCK-8, EDU, colony formation, Transwell invasion, and wound healing assays were performed to explore the function of KIAA1522 in HCC in vivo and in vitro. Finally, gene set enrichment analysis was used to identify the pathways involved. Results: Our results demonstrated that KIAA1522 was highly expressed in HCC tissues and cell lines. Furthermore, KIAA1522 overexpression was associated with unfavorable clinicopathological characteristics. Survival analyses revealed that KIAA1522 overexpression predicted lower recurrence-free and overall survival rates in patients with HCC. Functional studies suggested that KIAA1522 facilitated HCC proliferation, migration, and invasion both in vitro and in vivo. Moreover, KIAA1522 up-regulated the Wnt/β-catenin signaling pathway, as confirmed by TOP-flash/FOP-flash luciferase reporter assays and Western blotting. Conclusion: In conclusion, we highlighted the oncogenic role of KIAA1522 in HCC and determined its potential as a therapeutic target for HCC.

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Section: Discussionmentioning

confidence: 99%

<p>KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt/β-Catenin Signaling Pathway</p>

Jiang

Zhang

et al. 2020

OTT

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“…The ischemia results in astrocyte function impairment, an increased glutamate release, and disruption of glutamate uptake in astrocytes (35)(36)(37)(38). Mechanisms such as the lipid peroxidation of calcium, the activation of proteolytic enzymes, free radical production, and gene activation result in an increase in irreversible neuronal damage (33,39).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Rifampicin on Experimental Cerebral Ischemia/Reperfusion Injury in Rats

Arslan

Gel

Demir

et al. 2019

Iran Red Crescent Med J

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Background: Ischemic brain damage can be explained by the emergence of acute focal or global neurological findings caused by vascular occlusions or hemorrhages. Even in non-fatal cases, stroke is an important pathologic condition with a severe impact on the quality of life, and patients require considerable assistance in the daily lives. Objectives: The purpose of this study was to investigate the effect of rifampicin on malondialdehyde (MDA) levels and neurological examination of the hippocampal region in rats with transient cerebral ischemia. Methods: This experimental study has been performed in a university-affiliated animal lab, Trabzon, Turkey, in 2016. Thirty-eight Sprague Dawley rats weighing 220-280 g were used. In this two-vessel occlusion and hypotension ischemia-reperfusion model, the bilateral carotid arteries were temporarily clipped (30 minutes), and blood was withdrawn up to 3 mL of intracardiac volume before the induction of hypotension. After 30 minutes, the clips were removed, and a reperfusion medium was created. One group of 12 rats received intraperitoneal injections of 30 mg/kg of rifampicin every day, and after a 30-minute bilateral carotid artery clipping and hypotension (10 mL/kg). Another group of 12 rats underwent a 30-minute bilateral carotid artery clipping and hypotension (10 mL/kg). The third group consisting of 7 rats underwent skin laceration only. The final group of 7 rats received anesthesia for only 15 minutes. Neurological examinations were performed at the end of days 1, 4, 7, and 10 in all groups. At the end of the 10th day, the animals were euthanized, and their brain tissues were removed. The hippocampi were removed from the brains for biochemical analysis and stored at-76°C in a deep freeze. Ischemic changes in the brain were assessed biochemically by measuring MDA levels in both blood and brain tissue. Results: There was no statistically significant difference between the groups in terms of the mean tissue MDA levels (P = 0.112), but a significant difference was determined in the mean serum MDA values (P = 0.033). Serum MDA values significantly differed between the Group 1 and Group 2 (P = 0.030), but not between Group 1 and Group 3 (P = 0.58). Serum MDA values were also significantly different between Group 2 and Group 3 (P = 0.019), and between Group 2 and Group 4 (P = 0.035). Conclusions: Rifampicin could exhibit a neuroprotective effect on cerebral ischemia-reperfusion injury.

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“…The discovery of the Wnt signaling pathway returns back to 1982 when several scientists worked on a mouse with breast cancer (Nusse & Varmus, ). The focus on this signaling pathway is due to its major roles in various biological processes, so that it has been shown that the Wnt signaling pathway is involved in embryogenesis, cell proliferation, cell migration, cell differentiation, cell genesis, and tissue formation (Liang et al, ; Tang, Shen, Zhang, Yang, & Liu, ). There are a number of glycoprotein ligands which bind to the receptors.…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

Ashrafizadeh

Ahmadi

Farkhondeh

et al. 2019

Journal Cellular Physiology

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Wingless-type MMTV integration site (Wnt) signaling pathway is considered as an important pathway regulating a variety of biological processes such as tissue formation and homeostasis, cell proliferation, cell migration, cell differentiation, and embryogenesis. Impairment in the Wnt signaling pathway is associated with pathological conditions, particularly cancer. So, modulation of this pathway can be considered as a promising strategy and several drugs have been developed in line with this strategy. Resveratrol (Res) is a naturally occurring nutraceutical compound exclusively found in different fruits and nuts such as grape, peanut, and pistachio. This compound has favorable biological and therapeutic activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, cardioprotective, and antidiabetic. At the present review, we demonstrate how Res modulates Wnt signaling pathway to exert its pharmacological effects.

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Human serum albumin attenuates global cerebral ischemia/reperfusion-induced brain injury in a Wnt/β-Catenin/ROS signaling-dependent manner in rats

Cited by 27 publications

References 39 publications

<p>KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt/β-Catenin Signaling Pathway</p>

<p>KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt/β-Catenin Signaling Pathway</p>

The Effects of Rifampicin on Experimental Cerebral Ischemia/Reperfusion Injury in Rats

Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

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