Human serum albumin binding to silica nanoparticles – effect of protein fatty acid ligand

Ang, Joo Chuan; Henderson, Mark J.; Campbell, Richard A.; Lin, Jhih Min; Yaron, Peter N.; Nelson, Andrew; Faunce, Thomas; White, John W.

doi:10.1039/c4cp00293h

Cited by 17 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, since the HSA protein can hardly adsorb on negatively charged nanoparticles (with no hydrophobic part) due to the repulsively electrostatic interaction 44 , it is not necessary to coat stealth polymers onto their surface for HSA protein resistance. But notice that the surface of negatively charged nanoparticles in real experiments may be semi-hydrophilic or partially hydrophobic, thus the HSA protein could adsorb onto their surface 48 . However, the main driving force for protein adsorption in those cases is hydrophobic interaction (instead of electrostatic interaction) 48 , which is similar to that in the case of hydrophobic nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Design strategy of surface decoration for efficient delivery of nanoparticles by computer simulation

Ding

2016

Sci Rep

View full text Add to dashboard Cite

Understanding the role of surface decoration of nanoparticles in protein adsorption and cellular uptake is of great importance in biomedicine. Here, by using dissipative particle dynamics simulations, we take two typical coating polymers (i.e., hydrophilic and zwitterionic polymers) as an example, and systematically investigate their effect on cellular delivery of hydrophobic and charged nanoparticles (in the presence of serum protein). Our results show that though two types of polymers are charge-neutral and can both reduce the protein adsorption, there exist some differences between their ability of protein resistance, especially in the case of positively charged nanoparticles. Besides, it is found that the coating polymers may also greatly decrease the cellular uptake efficiency of nanoparticles. Nevertheless, and importantly, since the zwitterionic polymers may become positively charged under low pH environments, the nanoparticle can attach onto cell membrane more firmly than that coated with hydrophilic polymers, which can further enhance the active targeting of nanoparticles. Finally, we also provide the design maps for surface decoration to achieve efficient cellular delivery. These results can help better understand how to keep the balance between protein resistance and cell targeting, which may give some useful guidelines on optimal design of future nanomaterials in drug delivery.

show abstract

Section: Resultsmentioning

confidence: 99%

Design strategy of surface decoration for efficient delivery of nanoparticles by computer simulation

Ding

2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The same is also true of NP assembly into chains, sheets, twisted ribbons, and shells (6,7,36,61,62), as well as for assemblies of NPs with other chemical species. When NPs are combined with proteins, multiple examples of discontinuities and counterintuitive trends are ascribed to "patchy" interactions (63)(64)(65)(66). Many parallels in the behavior of NPs and globular proteins should also be noted (15,67,68).…”

Section: Illustration Of Deviationsmentioning

confidence: 95%

Nonadditivity of nanoparticle interactions

Batista

Larson

Kotov

2015

Science

442

240

View full text Add to dashboard Cite

Understanding interactions between inorganic nanoparticles (NPs) is central to comprehension of self-organization processes and a wide spectrum of physical, chemical, and biological phenomena. However, quantitative description of the interparticle forces is complicated by many obstacles that are not present, or not as severe, for microsize particles (μPs). Here we analyze the sources of these difficulties and chart a course for future research. Such difficulties can be traced to the increased importance of discreteness and fluctuations around NPs (relative to μPs) and to multiscale collective effects. Although these problems can be partially overcome by modifying classical theories for colloidal interactions, such an approach fails to manage the nonadditivity of electrostatic, van der Waals, hydrophobic, and other interactions at the nanoscale. Several heuristic rules identified here can be helpful for discriminating between additive and nonadditive nanoscale systems. Further work on NP interactions would benefit from embracing NPs as strongly correlated reconfigurable systems with diverse physical elements and multiscale coupling processes, which will require new experimental and theoretical tools. Meanwhile, the similarity between the size of medium constituents and NPs makes atomic simulations of their interactions increasingly practical. Evolving experimental tools can stimulate improvement of existing force fields. New scientific opportunities for a better understanding of the electronic origin of classical interactions are converging at the scale of NPs.

show abstract

“…18 Indeed it was argued in one fairly early study, 19 and is now becoming increasingly common, for layer roughness values whose minimum are consistent with the presence of capillary waves to be applied in models used to fit neutron reflectivity data at fluid interfaces. 20,21 Higher layer roughness values have been used in studies on proteins and nanoparticles 22 or crosslinked polymer nanogels 23 at the air/water interface. Also, in one early study on monolayers of hexadecyltrimethylammonium bromide that exploited kinematic data analysis, it was commented that the air/water interface is even rougher than that predicted from a simple capillary wave model.…”

Section: Introductionmentioning

confidence: 99%

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Campbell

Saaka

Shao

et al. 2018

Journal of Colloid and Interface Science

Self Cite

View full text Add to dashboard Cite

Specular neutron reflectometry is a powerful technique to resolve interfacial compositions and structures in soft matter. Surprisingly however, even after several decades, a universal modeling approach for the treatment of data of surfactant and phospholipid monolayers at the air/water interface has not yet been established. To address this shortcoming, first a systematic evaluation of the suitability of different models is presented. The result is a comprehensive validation of an optimum model, which is evidently much needed in the field, and which we recommend as a starting point for future data treatment. While its limitations are openly discussed, consequences of failing to take into account various key aspects are critically examined and the systematic errors quantified. On the basis of this physical framework, we go on to show for the first time that neutron reflectometry can be used to quantify directly in situ at the air/water interface the extent of acyl chain compaction of phospholipid monolayers with respect to their phase. The achieved precision of this novel quantification is ∼10%. These advances together enhance significantly the potential for exploitation in future studies data from a broad range of systems including those involving synthetic polymers, proteins, DNA, nanoparticles and drugs.

show abstract

Human serum albumin binding to silica nanoparticles – effect of protein fatty acid ligand

Cited by 17 publications

References 31 publications

Design strategy of surface decoration for efficient delivery of nanoparticles by computer simulation

Design strategy of surface decoration for efficient delivery of nanoparticles by computer simulation

Nonadditivity of nanoparticle interactions

Structure of surfactant and phospholipid monolayers at the air/water interface modeled from neutron reflectivity data

Contact Info

Product

Resources

About