Human study on cancer diagnostic probe (CDP) for real‐time excising of breast positive cavity side margins based on tracing hypoxia glycolysis; checking diagnostic accuracy in non‐neoadjuvant cases

Abstract

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Updates and Debate Concerning Margin Adequacy and Management following Breast-Conserving Surgery

“…A device based on nanotechnology is the cancer diagnostic probe that was observed to efficiently detect breast cavity side margins in real-time as well as after neoadjuvant treatment [55]. This device assesses the presence of hypoxia glycolysis associated with the tumor tissue [55].…”

“…A device based on nanotechnology is the cancer diagnostic probe that was observed to efficiently detect breast cavity side margins in real-time as well as after neoadjuvant treatment [55]. This device assesses the presence of hypoxia glycolysis associated with the tumor tissue [55]. Another approach based on an exogenous nanotechnology contrast agent (water-soluble melanin nanoparticles conjugated with cyclic Arg-Gly-Asp peptides) and photoacoustic imaging was proposed to guide surgery in vivo and assess free margins ex-vivo or in-vivo [56].…”

High-Frequency (30 MHz–6 GHz) Breast Tissue Characterization Stabilized by Suction Force for Intraoperative Tumor Margin Assessment

“…Incomplete fixation of adipose cells existing in dissected breast tumor Diagnostics 2023, 13, 179 2 of 11 margins is a crucial pitfall in the accuracy of frozen pathology in breast cancer surgeries [4], so at least 20-30% misdiagnosis in breast tumor margins was reported in the literature [5,6]. Thus, several types of research have been conducted to fill the gap and invent precise intraoperative complementary devices [7,8]. One of the most attractive methods for cancer detection has been based on tissue dielectric properties [9].…”