Human T‐cell leukemia virus type I infection as an oncogenic and prognostic risk factor in cervical and vaginal carcinoma

Miyazaki, K.; Yamaguchi, Keizo; Tohya, Toshimitsu; Ohba, Takayoshi; Takatsuki, Kiyoshi; Okamura, H.

doi:10.1016/0020-7292(91)90515-7

Cited by 19 publications

(17 citation statements)

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“…However, in contrast to HIV-1, HTLV-I has received little attention as a possible co-factor for cervical neoplasia. The HTLV-I seroprevalence rate among cervical cancer patients in Japan was reported to be about 3 times greater in patients under 59 years of age than healthy population-based controls (Miyazaki et al, 1991). However, there has been no corroboration of this result, and even if confirmed this relationship might just reflect the mutual association of HTLV-I and cervical cancer with sexual practices.…”

mentioning

confidence: 81%

Human T‐Cell lymphotropic virus type I and severe neoplasia of the cervix in jamaica

Strickler

Rattray

Escoffery

et al. 1995

Intl Journal of Cancer

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Human T-cell lymphotropic virus type I (HTLV-I) was associated with carcinoma of the cervix in Japan in a recent study that compared hospital cases with healthy population-based controls. To test this relationship in women more alike for cervical neoplasia risk factors (including sexual behavior and human papilloma virus; HPV), we enrolled consecutive patients from a colposcopy clinic in Kingston, Jamaica (an HTLV-I endemic area). Patients underwent Pap smear, colposcopy, biopsy and cervical swab for detection of HPV by polymerase chain reaction. Cases were defined as women with CIN-3 or invasive cancer (CIN-3/CA). Controls included all patients with either CIN-I or koilocytotic atypia, atypical squamous cells of undetermined significance or benign cervical pathology (all but one had at least inflammatory changes). Patients with CIN-2 were excluded to minimize risk of case-control misclassification. Cases were much more likely to be HTLV-I seropositive than controls. Although mean age differed significantly between cases (mean age = 39 years) and controls (mean age = 33 years), control for age did not explain the relation of CIN-3/CA with HTLV-I. Among HPV DNA positive subjects the age-adjusted association was not diminished but lost statistical significance. HTLV-I seroprevalence may be independently associated with progression to severe neoplasia of the cervix.

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mentioning

confidence: 81%

Human T‐Cell lymphotropic virus type I and severe neoplasia of the cervix in jamaica

Strickler

Rattray

Escoffery

et al. 1995

Intl Journal of Cancer

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“…The high prevalence of HTLV-1 carriers with cervical and vaginal carcinoma was studied using the cohort epidemiologic method. 13 The frequency of cancer (11.6%) superimposed on 43 patients with ATL was significantly greater than cancer prevalence (1.9%) among 155 subjects with HTLV-1 seronegative hematologic malignan- …”

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confidence: 97%

High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers

Kozuru

Uike

Muta

et al. 1996

Cancer

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“…In Japan, a cross-sectional study 22 observed higher prevalence of HTLV-1 infection in patients with cervical cancer, assigning a threefold higher risk for this malignancy. In Jamaica, a case-control study suggested that HTLV-1 infection was a risk factor for progression of cervical intraepithelial neoplasia 23 .…”

Section: Discussionmentioning

confidence: 99%

“…infection among HTLV-infected and uninfected groups when women were stratified into age ranges (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), 36-45, 46-55, and 56-65 years). Four positive cases of HPV infection (18.2%) were observed in HTLV-infected women with 46-55 years, whereas none was found in the control group at same age (p = 0.31) (data not shown).…”

Section: Ethical Considerationsmentioning

confidence: 99%

“…A higher frequency of HPV infection and an increased risk of cervical cancer are found in immunosuppressed women, as can be observed in human immunodeficiency virus (HIV)-infected patients [19][20][21] . The studies that assessed the association of HPV infection in HTLV-1 patients have not reached a consensus on the epidemiological aspects of this co-infection [22][23][24][25] . The aim of this study was to determine the prevalence of HPV infection in HTLV-1-infected women in the City of Salvador, Bahia, Brazil, and to establish the risk factors involved in this co-infection.…”

Section: Introductionmentioning

confidence: 99%

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Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Lôpo

Oliveira

Santana

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.

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Human T‐cell leukemia virus type I infection as an oncogenic and prognostic risk factor in cervical and vaginal carcinoma

Cited by 19 publications

References 0 publications

Human T‐Cell lymphotropic virus type I and severe neoplasia of the cervix in jamaica

Human T‐Cell lymphotropic virus type I and severe neoplasia of the cervix in jamaica

High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

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