Human T Lymphotropic Virus Type II (HTLV-II): Epidemiology, Molecular Properties, and Clinical Features of Infection

Hall, William W.; Ishak, Ricardo; Zhu, Shi Wei; Novoa, Patrícia; Eiraku, Nobutaka; Takahashi, Hitomi; Ferreira, M da Costa; Azevedo, Vânia Nakauth; Ishak, Marluísa de Oliveira Guimarães; Ferreira, Orlando da Costa; Monken, Claude E.; Kurata, T

doi:10.1097/00042560-199600001-00031

Cited by 120 publications

(100 citation statements)

References 82 publications

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“…HTLV-2 is prevalent in native populations, such as indigenous peoples in the Americas and Pygmy tribes in Africa, and in intravenous drug users [15][16][17][18][19] . Despite a 65% homology with HTLV-1, HTLV-2 has not been consistently associated with human disease; however, neurological disorders similar to HAM/TSP have been observed in patients with HTLV-2 infection 15,20 .…”

Section: Introductionmentioning

confidence: 99%

Sexual transmission of human T-cell lymphotropic virus type 1

Paiva

Casseb

2014

Rev. Soc. Bras. Med. Trop.

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Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic in many parts of the world and is primarily transmitted through sexual intercourse or from mother to child. Sexual transmission occurs more effi ciently from men to women than women to men and might be enhanced by sexually transmitted diseases that cause ulcers and result in mucosal ruptures, such as syphilis, herpes simplex type 2 (HSV-2), and chancroid. Other sexually transmitted diseases might result in the recruitment of infl ammatory cells and could increase the risk of HTLV-1 acquisition and transmission. Additionally, factors that are associated with higher transmission risks include the presence of antibodies against the viral oncoprotein Tax (anti-Tax), a higher proviral load in peripheral blood lymphocytes, and increased cervicovaginal or seminal secretions. Seminal fl uid has been reported to increase HTLV replication and transmission, whereas male circumcision and neutralizing antibodies might have a protective effect. Recently, free virions were discovered in plasma, which reveals a possible new mode of HTLV replication. It is unclear how this discovery might affect the routes of HTLV transmission, particularly sexual transmission, because HTLV transmission rates are signifi cantly higher from men to women than women to men.

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Section: Introductionmentioning

confidence: 99%

Sexual transmission of human T-cell lymphotropic virus type 1

Paiva

Casseb

2014

Rev. Soc. Bras. Med. Trop.

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“…2,3 In contrast, the correlation between HTLV-2 infection and hematopoietic malignancies is still controversial. [4][5][6][7] However, HTLV-2 infection of T cells in vitro results in spontaneous cell proliferation and transformation. 6,[8][9][10][11] In addition, HTLV-2 can be found in some patients with neurodegenerative and lymphoproliferative disorders and in a significant fraction (up to 10%) of intravenous drug users, frequently co-infected with human immunodeficiency virus (HIV)-1.…”

Section: Introductionmentioning

confidence: 99%

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34+ TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-γ and granulocyte macrophage–colony-stimulating factor

Bovolenta

Pilotti

Mauri

et al. 2002

Blood

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“…A descrição inicial do vírus linfotrópico humano de células T do tipo 2 (HTLV-2) aconteceu em 1982, em paciente com leucemia de células pilosas 42 . Informações adicionais sobre o HTLV-2 podem ser obtidas em outro estudo 34 .…”

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Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

Nobre

Guedes

Proietti

et al. 2005

Rev. Soc. Bras. Med. Trop.

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RESUMO O vírus linfotrópico humano de células T do tipo 1 (HTLV-1) é o primeiro retrovírus isolado do ser humano. Descreveuse, em pouco tempo, o seu papel etiológico em algumas doenças, com destaque para a leucemia/linfoma de células T do adulto (ATLL), a mielopatia associada ao HTLV-1/paraparesia espástica tropical (HAM/TSP) e a uveíte associada ao HTLV-1 (HAU). Na década de 90, o HTLV-1 foi associado a eczema grave da infância, conhecido como dermatite infecciosa (DI). Desde então, diversos outros tipos de lesões cutâneas têm sido observados em pacientes infectados pelo HTLV-1, em especial, nos doentes de HAM/TSP ou de ATLL. Porém, mesmo portadores assintomáticos do vírus apresentam doenças dermatológicas. Excetuando-se a dermatite infecciosa, não há lesão da pele específica da infecção pelo HTLV-1. Aqui, os autores apresentam as principais lesões dermatológicas descritas em pacientes infectados pelo HTLV-1, destacando o valor epidemiológico e clínico desses achados. Palavras-chaves: HTLV-1. Retrovírus. ATLL. HAM/TSP. Lesões dermatológicas. Pele. ABSTRACT Human T-cell Lymphotropic vírus type I (HTLV-1) was the first human retrovírus described. Some time after its discovery a group of diseases were related to this vírus, such as, adult T-cell leukemia lymphoma (ATLL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 associated uveitis (HAU). In the nineties, HTLV-1 was associated to a severe eczema of children, called infective dermatitis (ID

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Human T Lymphotropic Virus Type II (HTLV-II): Epidemiology, Molecular Properties, and Clinical Features of Infection

Cited by 120 publications

References 82 publications

Sexual transmission of human T-cell lymphotropic virus type 1

Sexual transmission of human T-cell lymphotropic virus type 1

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34+ TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-γ and granulocyte macrophage–colony-stimulating factor

Lesões dermatológicas em pacientes infectados pelo vírus linfotrópico humano de células T do tipo 1 (HTLV-1)

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