Human β3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

“Click Chemistry” in Zeolites: Copper(I) Zeolites as New Heterogeneous and Ligand‐Free Catalysts for the Huisgen [3+2] Cycloaddition

“…[10] For example, this reaction has been applied to the formation of anti-HIV compounds, [11] selective b 3 adrenergic receptor inhibitors, [12] antibacterial compounds, [13] potent antihistaminic compounds, [14] as well as agrochemicals. [15] 1,2,3-Triazoles themselves have also found extensive industrial use as corrosion inhibitors, [16] dyes, [17] and photostabilizers.…”

Synthetic Studies toward Aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-Diarylthiourea as Urea Mimetics

“…Interestingly, replacement of urea function in β 3 -adrenergic receptor agonists with triazole resulted in improved oral bioavailability accompanied by retention of potency, selectivity, and in vivo efficacy. 17 Replacement of the amide bond in Phe-Gly in substance P with [1,2,4]triazole peptide bond surrogate led to dramatic loss of affinity to the NK 1 receptor. 18 On the other hand, introduction of the same modification to dermorphin led to potent and selective pseudopeptides toward the μ receptor sub-type.…”

1-(2′-Ethoxy-4′-fluoro-[1,1′-biphenyl]-4-yl)-4-phenyl-1H-1,2,3-triazole

“…Nitrogen-containing heterocyclic compounds, such as 1,2,3-triazoles, have a wide-ranging biological spectrum, including anticancer activity (Duan et al, 2013), antitubercular activity (Somu et al, 2006), anti-HIV activity, antibacterial activity, antiallergic activity and selective 3 -adrenergic receptor agonism (Brockunier et al, 2000). They also have a wide range of other applications, such as dyes, corrosion inhibition, photostabilizers, photographic materials, and in the field of agrochemicals.…”