Humoral antibody responses to different H5N1 and H5N2 vaccination regimes: Implications for the development of autogenously based vaccines

Shany, Salama A. S.; El‐Kady, Magdy F.; Eid, Bahaa T. M.; Hassan, Eman R.; Abdel‐Moneim, Ahmed S.

doi:10.1016/j.vetmic.2011.06.006

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…In view of these data and previously published data, a minimum protective GMT of Ն1:128 was associated with protection in WL chickens if the field viruses were antigenically closely related to the vaccines, but data on the minimum HI titers associated with protection in other poultry species or breeds within a single poultry species are not available. Generally, WL chickens generate the strongest immune responses among all poultry species following a single immunization with a licensed vaccine, including higher titers than meat-type chickens, turkeys, and domestic ducks, but there is also significant variation in antibody responses by breed (64)(65)(66)(67). Some poultry species may require additional booster vaccinations to achieve sufficient levels of protection for their specific type of production system and the length of their production lives.…”

Section: Discussionmentioning

confidence: 99%

Antibody Titer Has Positive Predictive Value for Vaccine Protection against Challenge with Natural Antigenic-Drift Variants of H5N1 High-Pathogenicity Avian Influenza Viruses from Indonesia

Swayne

Suarez

Spackman

et al. 2015

J Virol

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Vaccines are used in integrated control strategies to protect poultry against H5N1 high-pathogenicity avian influenza (HPAI). H5N1 HPAI was first reported in Indonesia in IMPORTANCEH5N1 high-pathogenicity avian influenza (HPAI) virus has become endemic in Indonesian poultry, and such poultry are the source of virus for birds and mammals, including humans. Vaccination has become a part of the poultry control strategy, but vaccine failures have occurred in the field. This study identified possible causes of vaccine failure, which included the use of an unlicensed virus seed strain and induction of low levels of protective antibody because of an insufficient quantity of vaccine antigen. However, the most important cause of vaccine failure was the appearance of drift variant field viruses that partially or completely overcame commercial vaccine-induced immunity. Furthermore, experimental vaccines using inactivated wild-type virus or reverse genetics-generated vaccines containing the hemagglutinin and neuraminidase genes of wild-type drift variant field viruses were protective. These studies indicate the need for surveillance to identify drift variant viruses in the field and update licensed vaccines when such variants appear.

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Section: Discussionmentioning

confidence: 99%

Antibody Titer Has Positive Predictive Value for Vaccine Protection against Challenge with Natural Antigenic-Drift Variants of H5N1 High-Pathogenicity Avian Influenza Viruses from Indonesia

Swayne

Suarez

Spackman

et al. 2015

J Virol

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“…It would also be possible that with each booster vaccination the immune protection against Salmonella infection increased [ 16 , 17 ]. The memory immune response might have impeded the systemic spread and even the caecum colonization of the vaccine strains.…”

Section: Main Textmentioning

confidence: 99%

Antibody titers in turkeys increase after multiple booster vaccinations with an attenuated Salmonella live vaccine

Hesse¹,

Weber²,

Glünder³

2018

BMC Res Notes

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ObjectiveHuman Salmonellosis is one of the most frequently reported foodborne zoonoses in the European Union. The most common source of human infections is the consumption of poultry products. Besides management and hygiene practices vaccination of poultry livestock is seen as one way to reduce Salmonella infections in humans. Turkey flocks in Europe are frequently infected with Salmonella and until recently there was no live vaccine for turkeys available. The aim of the present study was to examine the development of humoral antibodies after repeated vaccination with a bivalent live Salmonella vaccine containing attenuated Salmonella Typhimurium and Salmonella Enteritidis strains. Furthermore the colonization of the caecum with the vaccine strains and their spread to liver and spleen as well as the course of their fecal excretion was observed.ResultsAntibody production was hardly detectable after the first vaccination but increased after booster vaccinations. Both the Salmonella Enteritidis and the Salmonella Typhimurium vaccine strain were reisolated from caecum contents and organ samples. After booster vaccinations the re-isolation rates were reduced. The shedding of the vaccine strains was most pronounced after the first vaccination.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3462-y) contains supplementary material, which is available to authorized users.

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Widespread of H5N1 infections in apparently healthy backyard poultry

Abozaid¹,

Aly

Abdel‐Moneim

et al. 2016

Trop Anim Health Prod

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Highly pathogenic avian influenza subtype H5N1 represents a threat to the poultry industry and human health worldwide. Inapparently infected birds are suspected to play an essential role in the spread of avian influenza virus. In the current study, a total of 25,646 samples (16,185 chicken, 4696 ducks, 1633 geese and 3132 turkeys) from apparently healthy birds were screened for the presence of positive samples for H5N1 during 2009-2014. The samples were examined by reverse transcriptase real-time polymerase chain reaction (rRT-PCR) for M, H5 and N1 genes of avian influenza viruses. The results revealed that the HPAI H5N1 existed in an inapparent manner in ducks (4.68 %), geese (4.10 %), chickens (2.48 %) and turkeys (2.29 %). The current finding highlights the serious impact of such type on birds in the epidemiology of H5N1 in birds, animals and humans. It also highlights the existence of another reason other than vaccination that contributes to the widespread of inapparent infection of H5N1 in Egypt.

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Humoral antibody responses to different H5N1 and H5N2 vaccination regimes: Implications for the development of autogenously based vaccines

Cited by 6 publications

References 17 publications

Antibody Titer Has Positive Predictive Value for Vaccine Protection against Challenge with Natural Antigenic-Drift Variants of H5N1 High-Pathogenicity Avian Influenza Viruses from Indonesia

Antibody Titer Has Positive Predictive Value for Vaccine Protection against Challenge with Natural Antigenic-Drift Variants of H5N1 High-Pathogenicity Avian Influenza Viruses from Indonesia

Antibody titers in turkeys increase after multiple booster vaccinations with an attenuated Salmonella live vaccine

Widespread of H5N1 infections in apparently healthy backyard poultry

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