Humoral immune and adjuvant responses of mucosally-administered Tinospora cordifolia immunomodulatory protein in BALB/c mice

Aranha, Ivan; Venkatesh, Yeldur P.

doi:10.1016/j.jaim.2017.10.006

Cited by 14 publications

(3 citation statements)

References 42 publications

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“…Amritarishta is given for the treatment of chronic fever, and to fight infections, as its main contain Guduchi is a natural immunity booster and increases non-specific immunity. [74] Shwasakuthara Rasa and Naradiya Lakshmivilasa Rasa are given in high-grade fever, cough, and dyspnea along with inflammatory conditions in respiratory tract disorders. Acharya Charaka quoted to use Shadangapaneeya (medicated lukewarm water) is given in persons with high-grade fever.…”

Section: Nd Stage (Covid-19 Positive With Specific Symptoms At Modera...mentioning

confidence: 99%

Relevance of ayurveda in coronavirus disease-2019

Mishra

2022

MEDINDIA

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India is the land living of culture, religious beliefs, and traditional knowledge. The great sages of India chanted mantras to get revive from all sorts of problems and its echoes have helped the ailing societies through centuries. A very popular mantra, from Brihadaranyaka Upanishad (1.4.14), conveys that “May all human beings be at peace, may no one suffer from illness/disease, May all see what is auspicious, may no one suffer.” The expedition for happiness and success has been the dynamic factor in the course of our evolutionary history. Health is wealth but it matters only once someone gets sick; it is the reality in current situation when entire humanity along with its complete health-care system combatting with an unprecedented challenge by the name of pandemic coronavirus disease-2019 (COVID-19). All the treatment modalities in the medical system approach are being implemented to fight with this deadly viral disease. There are many references available in the ancient Ayurvedic Samhitas/ classics text books about “Janapadodhwans” or epidemics along with its causes, pathogenesis, and management. The practical knowledge and the knowledge about the stage of the disease are essential to bridge the Ayurvedic principles with the preventive and curative aspects of the disease. The efficiency of Ayurvedic drugs is known by its age long practice. However, new drugs can be formulated with a combination of drugs. The search for new drugs and new preventive practices in an integrated approach is what the approach needed to tackle the novel virus. In this regard, a literary work effort has made to find how Ayurveda can help to face growing challenge of COVID-19 with respect to various stages of disease in Ayurvedic perspective.

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Section: Nd Stage (Covid-19 Positive With Specific Symptoms At Modera...mentioning

confidence: 99%

Relevance of ayurveda in coronavirus disease-2019

Mishra

2022

MEDINDIA

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“…extract of T. cordifolia which was subjected to protein precipitation on BALB/c mice (at a dose of at 30 µg on days 1, 14, 21, 28, 35 and 42 through nostril) showed increase in body weight (p<0.005) on day 50 compared to day 1 in test group, thus showed humoral immune response (serum IgG and IgA increased) and indicated its intrinsic immunogenicity. 9 Sachan and co-workers studied the Immunomodulatory potential of Aq. extract of T. cordifolia on (SPF) chicks infected with very virulent IBDV (vvIBDV) (at a dose of 50 µg/bird/day via intramuscular injection and 10 ml/bird/day orally for 4 weeks).…”

Section: Animal Studiesmentioning

confidence: 99%

Immunomodulatory activity of Tinospora cordifolia

Shivananjappa

Vidya²,

Manasa³

et al. 2022

IJNMHS

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Guduchi also known as having heart shaped leaves, belongs to family Menispermaceae native to Indian subcontinent. The aqueous and methanol stem extract of is being used for their Immunomodulatory activity as they revive immune imbalance which helps in preventing and healing many diseases. is intensively being studied for its immunomodulating effects because of its wide-ranging uses in treating diseases related to immune system in indigenous medicine. Various clinical trials for the treatment of HIV infection and other viral infections with TC is scientifically evaluated. In such conditions effective immune system is needed for curing the disease. has been proved for its ability to activate and modulate the immune system. Present paper is an attempt to assemble the information based on several experimental and clinical reports on immunomodulating role of

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“…These classic formulations impart their effect by increased production of cytokine, IL-2 and IFNγ, enhanced natural killer cells, and CD4 + /8 + T cell activities. Some of the poly-herbal formulations can be used as adjuvants with the vaccine to obtain safer and stronger immune responses ( Sakure et al, 2008 , Aranha and Venkatesh, 2020 ). The concept of immunity ( Vyadhikshamatwa ) is mentioned in the Ayurvedic system of medicine ( Rasayana ) which relies on a holistic approach for the prevention of diseases by boosting immunity through diet, lifestyle, and natural medicines ( Masram et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%