Humoral Immunity in Patients With Tinea Versicolor

Wu, Yi Chang; Chen, Kung-Tung

doi:10.1111/j.1346-8138.1985.tb01554.x

Cited by 22 publications

(9 citation statements)

References 26 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding suggested that opsonized M. furfur could be recognized via complement receptor type 3, and supported the results reported by Szabo et al in the case of C. albicans [17]. M. furfur could activate the alternative and classical pathways of complement (unpublished data), and it is reported that natural antibody against M. furfur existed in normal human serum [18, 19]. But in this paper, we did not demonstrate the recognition of M. furfur via Fc receptor in the experiment using heat‐inactivated serum, because heating at 56°C would lead to denaturation of complement components, not of antibody.…”

Section: Discussionsupporting

confidence: 89%

Soluble mannan and Î²-glucan inhibit the uptake ofMalassezia furfurby human monocytic cell line, THP-1

Suzuki

Ohno

Ohshima

et al. 1998

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

The uptake of live and heat-killed Malassezia furfur HIC 3321, HIC 3343 and Candida albicans ATCC 10231 by human monocytic cell line, THP-1, was examined. THP-1 was differentiated by PMA for 7 days before use. The uptake of these yeasts by THP-1 was increased in a concentration-dependent manner of yeasts, and the uptake reached plateau level at the E/T (yeast/THP-1) ratio 5. In addition, a higher percentage of heat-killed cells than live cells was taken in THP-1. Yeast mannan and beta-1,3-glucan, random coiled conformer, inhibited the uptake of live and heat-killed M. furfur by THP-1, though dextran T-250, that is alpha-glucan, and schizophyllan (SPG), triple helix conformer of beta-glucan, did not. Interestingly, mannan inhibited the uptake of both types, live and heat-killed, of C. albicans, however, laminaran inhibited the uptake of heat-killed C. albicans alone. Opsonization of these yeasts with normal human serum enhanced the uptake of yeasts, although opsonization with heat-inactivated serum, the treatment at 56 degrees C for 30 min, did not enhance. These results suggested that live and heat-killed M. furfur was recognized by THP-1 through mannose receptor, beta-glucan receptor and complement receptor type 3 via the activation of alternative pathway of complement.

show abstract

Section: Discussionsupporting

confidence: 89%

Soluble mannan and Î²-glucan inhibit the uptake ofMalassezia furfurby human monocytic cell line, THP-1

Suzuki

Ohno

Ohshima

et al. 1998

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Antibodies against Malassezia are found in both pityriasis versicolor patients and normal subjects 46 . In some experiments, antibody titres have been shown to be elevated in patients, 50–52 although other investigators have found no difference between patients and controls 53 . It appears that a significant humoral immune response occurs only with infection by the fungus, rather than in mere colonization.…”

Section: Immune Response To Malassezia In Pityriasis Versicolormentioning

confidence: 99%

Pityriasis versicolor

Gupta

Bluhm

Summerbell

2002

Acad Dermatol Venereol

153

168

View full text Add to dashboard Cite

show abstract

“…The first study to examine the levels of different isotypes of immunoglobulins was reported by Wu and Chen (476). They found that the mean total IgG and total IgM levels in patients were reportedly significantly higher than the levels in controls (P Ͻ 0.005), but the method of statistical analysis was not stated.…”

Section: Pityriasis Versicolormentioning

confidence: 99%

Immunology of Diseases Associated withMalasseziaSpecies

2002

View full text Add to dashboard Cite

SUMMARY Malassezia species are members of the human cutaneous commensal flora, in addition to causing a wide range of cutaneous and systemic diseases in suitably predisposed individuals. Studies examining cellular and humoral immune responses specific to Malassezia species in patients with Malassezia-associated diseases and healthy controls have generally been unable to define significant differences in their immune response. The use of varied antigenic preparations and strains from different Malassezia classifications may partly be responsible for this, although these problems can now be overcome by using techniques based on recent work defining some important antigens and also a new taxonomy for the genus. The finding that the genus Malassezia is immunomodulatory is important in understanding its ability to cause disease. Stimulation of the reticuloendothelial system and activation of the complement cascade contrasts with its ability to suppress cytokine release and downregulate phagocytic uptake and killing. The lipid-rich layer around the yeast appears to be pivotal in this alteration of phenotype. Defining the nonspecific immune response to Malassezia species and the way in which the organisms modulate it may well be the key to understanding how Malassezia species can exist as both commensals and pathogens.

show abstract

Humoral Immunity in Patients With Tinea Versicolor

Cited by 22 publications

References 26 publications

Soluble mannan and Î²-glucan inhibit the uptake ofMalassezia furfurby human monocytic cell line, THP-1

Soluble mannan and Î²-glucan inhibit the uptake ofMalassezia furfurby human monocytic cell line, THP-1

Pityriasis versicolor

Immunology of Diseases Associated withMalasseziaSpecies

Contact Info

Product

Resources

About