2016
DOI: 10.1016/j.trim.2016.08.004
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Humoral immunity in phenotypes of chronic lung allograft dysfunction: A broncho-alveolar lavage fluid analysis

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Cited by 40 publications
(38 citation statements)
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“…Unfortunately, given the long time span to collect these lungs and the evolving techniques, data on C4d staining were not available in our patient group. Recently, our group demonstrated increased levels of immunoglobulins and complement proteins (C4d and C1q) in BAL fluid of RAS which strengthens our hypothesis that AMR might overlap with RAS .…”
Section: Discussionsupporting
confidence: 82%
“…Unfortunately, given the long time span to collect these lungs and the evolving techniques, data on C4d staining were not available in our patient group. Recently, our group demonstrated increased levels of immunoglobulins and complement proteins (C4d and C1q) in BAL fluid of RAS which strengthens our hypothesis that AMR might overlap with RAS .…”
Section: Discussionsupporting
confidence: 82%
“…66,72,73 In recent years, quantitative BAL research has helped to illicit some of the biomarkers and cell lines upregulated within the subtypes of CLAD; however, the underlying mechanisms and therapies remain elusive. 72,73 Most strategies currently aim at the prevention of gastroesophageal reflux disease and use of azithromycin, whereas other treatments have had small or no impact. 69,74 There is much room to grow in preventing and developing innovative treatments for CLAD.…”
Section: Extended Criteria For Donor Selectionmentioning
confidence: 99%
“…lymphoid follicles, which is a common finding in other chronic respiratory diseases (62). Given this presence of lymphoid follicles, it comes as no surprise that immunoglobulin levels were also increased in rCLAD (63). Therefore, this raises the question to which extent rCLAD overlaps with chronic antibody-mediated rejection (AMR).…”
Section: Risk Factors and Mechanismsmentioning
confidence: 99%