Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Antibodies Reactive with
            <i>Actinomyces naeslundii</i>
            Genospecies 1 and 2 during Colonization

Cole, Michael F.; Bryan, Stacey; Evans, Mishell K.; Pearce, Cheryl L.; Sheridan, Michael J.; Sura, Patricia A.; Wientzen, Raoul L.; Bowden, G. H.

doi:10.1128/iai.66.9.4283-4289.1998

Cited by 20 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cole et al, 1998), we found A. odontolyticus as the first and the most frequent colonizer among the genus. This species also remained the most prominent Actinomyces finding in the oral…”

mentioning

confidence: 63%

Oral Colonization with Actinomyces Species in Infants by Two Years of Age

et al. 2000

View full text Add to dashboard Cite

In early childhood, the human mouth is already colonized by actinomycetes. Due to recent taxonomic changes within the genus Actinomyces, up-to-date data are warranted on the time and succession of different Actinomyces species in the oral cavity. By using a longitudinal study design and culture techniques, we examined the age-related occurrence of Actinomyces species in saliva from 39 healthy infants at 2, 6, 12, 18, and 24 months of age. Altogether 428 Actinomyces isolates were available for this study. Identification was based on biochemical tests and gas chromatographic demonstration of metabolic end-products, and when needed, cellular fatty acid profiles were determined. The frequency of the total actinomycetal flora increased from 31% to 97% within 2 years. A. odontolyticus was the most prominent Actinomyces colonizer at all five sampling occasions. A. naeslundii was the second most common Actinomyces sp. but was not detected before the age of 1 year. As a novel observation, we found A. graevenitzii in the oral cavity. The number of A. graevenitzii isolates indicates that this species is not just occasionally present in infants' mouths. We also found A. viscosus, A. gerencseriae, A. israelii, and A. georgiae. Based on the present results, we suggest that A. odontolyticus is the main primary Actinomyces species on oral mucosal surfaces in infants up to 2 years of age.

show abstract

“…Cole et al, 1998), we found A. odontolyticus as the first and the most frequent colonizer among the genus. This species also remained the most prominent Actinomyces finding in the oral…”

mentioning

confidence: 63%

Oral Colonization with Actinomyces Species in Infants by Two Years of Age

et al. 2000

View full text Add to dashboard Cite

show abstract

“…It is well-established that certain proteins and glycoproteins in saliva serve as receptors for bacterial adhesins, and thus may be a prerequisite for bacterial colonization of teeth (Gibbons, 1989;Scannapieco, 1994). In this regard, the natural acquisition of bacteria such as Streptococcus mutans, S. sanguinis, and Actinomyces naeslundii, as well as oral anaerobes such as Fusobacterium nucleatum, was shown to be correlated with tooth emergence (Smith and Taubman, 1993;Cole et al, 1998;Könönen et al, 1999;Caufield et al, 2000;Wan et al, 2003). Furthermore, it is known that certain salivary proteins exert functions both in innate mucosal immunity and for the protection of mineralized tooth surfaces (Mandel, 1987;Tabak, 1995).…”

Section: Discussionmentioning

confidence: 99%

Proteins in Whole Saliva during the First Year of Infancy

et al. 2005

View full text Add to dashboard Cite

During the first year of an infant's life, the oral environment is subject to drastic changes that coincide with the eruption of teeth. Proteins in saliva are important for protecting oral surfaces and provide receptors for bacterial adhesins. The objective of this longitudinal study was to monitor the general composition and expression of proteins in whole saliva of infants, to prove the hypothesis that expression of certain proteins changes during infant development, and might be associated with tooth eruption. The results showed a remarkable constancy in the overall pattern of salivary proteins and glycoproteins during infancy. Exceptions were the mucins and albumin. The mucins are expressed differentially, with first MUC7 and later MUC5B being predominant. Albumin, a marker of serum leakage, started to rise in whole saliva preceding tooth eruption. Thus, the expression of only few proteins appears to be changed during infant development.

show abstract

“…67 As earlier-arriving species have an ecological advantage over those arriving later, it is likely that early arrival of MS will promote their persistance in the mouth compared to later arrival. 68,69…”

Section: Factors Which Affect Mutans Streptococci Transmissionmentioning

confidence: 99%

Factors influencing oral colonization of mutans streptococci in young children

Law

Seow

Townsend

2007

Australian Dental Journal

138

119

View full text Add to dashboard Cite

This paper aims to critically review current knowledge about the key factors involved in oral colonization of the cariogenic group of bacteria, mutans streptococci (MS) in young children. MS, consisting mainly of the species Streptococcus mutans and Streptococcus sobrinus, are commonly cultured from the mouths of infants, with prevalence of infection ranging from around 30 per cent in 3 month old predentate children to over 80 per cent in 24 month old children with primary teeth. MS is usually transmitted to children through their mothers, and the risk of transmission increases with high maternal salivary levels of MS and frequent inoculation. Factors that affect the colonization of MS may be divided into bacterial virulence, hostrelated and environmental factors. Complex interaction among these factors determine the success and timing of MS colonization in the child. As clinical studies have shown that caries risk is correlated with age at which initial MS colonization occurred, strategies for the prevention of dental caries should include timely control of colonization of the cariogenic bacteria in the mouths of young children.

show abstract

Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Antibodies Reactive with Actinomyces naeslundii Genospecies 1 and 2 during Colonization

Cited by 20 publications

References 28 publications

Oral Colonization with Actinomyces Species in Infants by Two Years of Age

Oral Colonization with Actinomyces Species in Infants by Two Years of Age

Proteins in Whole Saliva during the First Year of Infancy

Factors influencing oral colonization of mutans streptococci in young children

Contact Info

Product

Resources

About