Humoral Regulation of Compensatory Renal Growth

A renotropic system in rats.

“…It occurred to us that our original renotropic factor in plasma or sera from UNI (3) enhanced DNA synthesis only in kidney tissue. Specific localization of tissue activator and its excitatory product could explain why only renal cortical tissue not liver, spleen, or lung tissue is affected by UNI plasma or sera (3,4). This is consistent with the possibility that renotropin is inactive until it is in the presence of renal tissue.…”

“…Received for publication 10 May 1974 and in revised form 17 September 1975. tor was indicated by the inability of similar plasma to stimulate isotope incorporation into the DNA of rat liver, renal medullary, spleen, and lung slices (4). While the source of this circulating renotropic factor was not identified, an interesting observation was the absence of stimulation by plasma from rats having both (bilateral nephrectomy) rather than one kidney removed (3).…”

Stimulation of Thymidine and Uridine Incorporation into Rat Renal Cortical Cells in Primary Monolayer Culture by Uninephrectomized Rat Serum

“…A significant facil itation of thymidine uptake was similarly observed in the experiment using uniserum 2 days after nephrectomy, in which the thymidine uptake into the cells treated with uni serum was 155% that of the cells treated with the sham serum. The primary monolayer culture of the rat renal cortex was, thus, sensitive to renotropin in stimulating the thymidine uptake, as has previously been reported in rat renal cortical fragments [10][11][12], Uptake of 14C-uridine by the cultured renal cells was also observed at serum concentrations ranging from 1.0 to 10% with both sham and unisera. Being consistent with previous reports concerning cortical slices [13] or the pri mary monolayer culture of the hamster kidney [3], uridine uptake by cells treated with uniserum tended to be higher than that by cells treated with sham serum in the range of 5-10% serum, although the difference was not statistically significant.…”

Neonatal Kidney Grafts into Adult Recipients

“…In the development of the renal hypertrophy [4], be side the genuine hemodynamic factors [5,6] that play an important role, there are other factors, such as age, sex of receptor, remnant renal mass (previous bilateral neph rectomy), diet, hormones or immunosuppression [7][8][9], These factors must be analyzed in large series before exclusive criteria are established taking into account the scarcity of donors, while the demand continuously rises.…”