Huntington's disease: A generalized membrane defect

Butterfield, D. Allan; Markesbery, William R.

doi:10.1016/0024-3205(81)90689-5

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1982

1989

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Cited by 31 publications

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“…[10] and Butterfield and Markesbery [12] interpret these results to mean that HD is the expression of a general ized membrane defect.…”

Section: Introductionmentioning

confidence: 99%

Spin Label Study of Red Blood Cell Membranes in Huntington’s Disease

Kraus¹,

Vigenschow²,

Przuntek³

1986

Eur Neurol

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Huntington’s disease (HD) is an inherited degenerative disorder of the central nervous system. Various studies of peripheral tissues from HD patients have led to the assumption that this disease could be the expression of a generalized membrane defect. We have been unable to reproduce fundamental results on which this theory is based, namely differences between electron spin resonance spectra for erythrocytes from diseased and healthy persons. Contradictory results have been published for other methods as well so that it is necessary to rethink the membrane defect theory.

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“…[10] and Butterfield and Markesbery [12] interpret these results to mean that HD is the expression of a general ized membrane defect.…”

Section: Introductionmentioning

confidence: 99%