Huperzine A for vascular dementia

Zeng, Hao; Liu, Ming; Liu, Zhiqin; D, Lv

doi:10.1002/14651858.cd007365.pub2

Cited by 31 publications

(31 citation statements)

References 28 publications

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“…The alkaloid galanthamine ( 21 ), which is approved in several countries for the treatment of Alzheimer’s disease (Birks, 2006), was found to be present in bulb, flower and leaf tissues of wild daffodil ( Narcissus pseudonarcissus L. (Amaryllidaceae). The sporophyte of Huperzia squarrosa , a clubmoss, was demonstrated to contain the alkaloid huperzine A ( 22 ), which is currently being investigated in advanced clinical trials for the treatment of vascular dementia in China (Hao et al, 2009). The benzylisoquinoline alkaloids morphine ( 7 ) and codeine ( 23 ) were readily detectable in capsule, leaf and root extracts of the opium poppy ( Papaver somniferum L.; Papaveraceae).…”

Section: Resultsmentioning

confidence: 99%

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

et al. 2013

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We report the development and testing of an accurate mass – time (AMT) tag approach for the LC/MS-based identification of plant natural products (PNPs) in complex extracts. An AMT tag library was developed for approximately 500 PNPs with diverse chemical structures, detected in electrospray and atmospheric pressure chemical ionization modes (both positive and negative polarities). In addition, to enable peak annotations with high confidence, MS/MS spectra were acquired with three different fragmentation energies. The LC/MS and MS/MS data sets were integrated into online spectral search tools and repositories (Spektraris and MassBank), thus allowing users to interrogate their own data sets for the potential presence of PNPs. The utility of the AMT tag library approach is demonstrated by the detection and annotation of active principles in 27 different medicinal plant species with diverse chemical constituents.

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Section: Resultsmentioning

confidence: 99%

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

et al. 2013

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“…Among studies which have included VaD patients, one Cochrane review investigated HupA for VaD but only identified one small study involving 14 participants in which HupA was found to be no better than placebo [37]. A subsequent meta-analysis of placebo-controlled RCTs of HupA on patients with AD and VaD identified eight AD and two VaD trials with 733 and 92 participants, respectively [38].…”

Section: Individual Herbs Used In Vadmentioning

confidence: 99%

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence

Chang

Liu

Bilinski

et al. 2016

Evidence-Based Complementary and Alternative Medicine

115

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Dementia is a leading cause of mental and physical disability. Vascular dementia (VaD) is the second most common cause of dementia after Alzheimer's disease (AD) constituting 10–15% of the dementia population. Currently there are no approved pharmaceutical options for VaD and the conventional anti-AD therapies provide only modest, short-term relief of symptoms associated with VaD. Herbal medicines have been used for the management of dementia-like symptoms for centuries and may provide viable therapies for VaD due to their multicomponent and multitarget approach. This review is designed to provide an updated overview on the current status of herbal medicine research, with an emphasis on Chinese herbal medicine, for the treatment of VaD or dementia. A case study is also provided to demonstrate the development process of a novel standardized complex herbal formulation for VaD. The article reveals some preliminary evidence to support the use of single and complex herbal preparations for VaD and dementia. Multiple issues in relation to clinical and preclinical research have been identified and future research directions are discussed.

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“…In fact, Huperzine A has been used for treating AD and mild memory deficits since 1994 in the China [55, 56]. In a randomized, double-blinded placebo-controlled clinical trial with the participation of 78 patients who have mild to moderate VaD, Huperzine A treatment significantly improved the cognitive functions in these patients [57].…”

Section: Therapeutic Implications For Vci With Traditional Chinesementioning

confidence: 99%

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

Zhou

Cui

Tseng

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The prevalence of cognitive impairment and dementia caused by cerebrovascular disease is likely to increase with the global aging population. Vascular contributions to cognitive impairment and dementia (VCID) is a wide spectrum term used to include a diverse heterogeneous group of cognitive syndromes with vascular factors regardless of the cause of pathogenesis. VCID ranges from mild cognitive impairment to full-blown dementia with vascular dementia (VaD) as the most severe stage. It is further complexed by the coexistence of other forms of dementia such as Alzheimer's disease (AD). Recent researches in the functions of the neurovascular unit (NVU) suggest that dysfunction of the NVU might be the cause of primary vascular events in the brain that leads to further neurodegeneration. In this review, we have briefly summarized various forms of VCID. There is currently no standard therapy for VCID or dementia. Given the fact that Traditional Chinese Medicine (TCM) has gained popularity worldwide, we also reviewed recent scientific and clinical findings on various antidementia TCM for the treatment of VCID, including Salvia miltiorrhiza, Huperzia serrata, Ligusticum chuanxiong, Ginkgo biloba, Panax ginseng, and also TCM formula Sailuotong capsule (SLT) and Fufangdanshen tablets (FFDS).

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Huperzine A for vascular dementia

Abstract: Background-Huperzine A, a form of herbal medicine, has been considered as an alternative treatment for vascular dementia (VaD) in China.

Cited by 31 publications

References 28 publications

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Accurate mass–time tag library for LC/MS-based metabolite profiling of medicinal plants

Herbal Medicine for the Treatment of Vascular Dementia: An Overview of Scientific Evidence

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine

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