Hürthle Cell Carcinoma of the Thyroid with Bilateral Pneumothorax

Nenkov, Rumen; R, Radev; Christosov, K.; Sechanov, T

doi:10.1089/thy.2005.15.627

Cited by 3 publications

(3 citation statements)

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“…On rare occasion, patients with primary or metastatic lung cancer present with spontaneous pneumothorax. [2][3][4][5][6][7][8][9] In the general population, 10 of 1,143 cases with spontaneous pneumothorax are attributed to a malignancy. 3 The most common malignant tumors are metastatic sarcomas, [3][4][5] including osteosarcoma and angiosarcoma, germ cell tumors 2 and primary lung cancers.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 We found two cases of spontaneous pneumothorax associated with metastatic thyroid carcinomas in the English medical literature. 8,9 Various mechanisms have been proposed as possible causes of spontaneous pneumothorax in patients with malignancy. Necrosis within a tumor itself, mechanical airway obstruction by tumor, chemotherapy-related tumor shrinkage and direct tumor invasion of the pleura may predispose a person to the development of pneumothorax.…”

Section: Discussionmentioning

confidence: 99%

“…1 Primary or metastatic malignant neoplasms are rare but very important underlying cause of spontaneous pneumothorax. [2][3][4][5][6][7][8][9] We report here on a 32-year-old male with microscopic pulmonary metastasis from a clinically undetected thyroid papillary carcinoma, who initially presented with recurrent spontaneous pneumothorax. This case was difficult to diagnose because the metastatic tumor exclusively revealed a follicular growth pattern and mild cytological atypia in an unusual anatomic site.…”

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Spontaneous Pneumothorax as an Initial Manifestation of Metastatic Papillary Thyroid Carcinoma

Lee

Kim

2009

Korean J Pathol

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Spontaneous pneumothorax occurs in a variety of lung diseases. Primary or metastatic lung cancers are rare, but important causes of pneumothorax. We report here on a case of pulmonary metastasis of thyroid papillary carcinoma that initially presented as spontaneous pneumothorax. A 32-year-old male with no history of thyroid disease underwent wedge resection of the lung due to recurrent pneumothorax. Histologically, the pleura and subpleural lung parenchyma revealed several micronodular lesions and randomly scattered glandular structures with mild cytological atypia. The cells were characterized by their overlapped hypochromatic nuclei with longitudinal grooves and inconspicuous nucleoli. On the additional sections, we found a few intranuclear inclusions and colloid-like material in the follicular structures. The glandular cells were immunoreactive for thyroglobulin, TTF-1, CK 7 and HMW-CK and they were focally immunoreactive for EMA, but they were negative for S100, chromogranin and CEA. The Ki-67 labelling index was 4%. Neck ultrasonography revealed an ill-defined hypoechoic nodule in the left lobe of the thyroid. The diagnosis of conventional, classical papillary carcinoma was made by both the cytology and the total thyroidectomy specimen. Pathologists should conduct a through histologic examination for the patients with recurrent spontaneous pneumothorax to search for the underlying causes.

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