2000
DOI: 10.1007/s004280000219
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Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance

Abstract: The molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / Hürthle cells and their respective tumours are reviewed in a series of sections: "Mitochondria, ageing, neurodegenerative diseases and cancer", "Mitochondrial abnormalities in Hürthle cells and Hürthle cells tumours", "Mitochondrion-related alterations in tumours with and without Hürthle cell/oncocytic features", "True and secondary oxyphilia", and "Bcl-2 expression, apoptosis and necrosis in Hürthle cell tumours and tumour-li… Show more

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Cited by 119 publications
(133 citation statements)
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References 63 publications
(114 reference statements)
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“…Medullary and poorly differentiated carcinomas may also display oncocytic features. 9,10,66,67 Hü rthle cells are stuffed with the mitochondria with morphological, functional and genetic abnormalities. 9,10,66,67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial enzymes.…”
Section: Differential Diagnosis Between Widely Invasive Ftc and Poorlmentioning
confidence: 99%
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“…Medullary and poorly differentiated carcinomas may also display oncocytic features. 9,10,66,67 Hü rthle cells are stuffed with the mitochondria with morphological, functional and genetic abnormalities. 9,10,66,67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial enzymes.…”
Section: Differential Diagnosis Between Widely Invasive Ftc and Poorlmentioning
confidence: 99%
“…9,10,66,67 Hü rthle cells are stuffed with the mitochondria with morphological, functional and genetic abnormalities. 9,10,66,67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial enzymes. 9,10,68,69 Regardless of the mechanism(s) involved in the process, a deficient mitochondrial function leads to an increased number of mitochondria through the stimulation of mitochondrial proliferation.…”
Section: Differential Diagnosis Between Widely Invasive Ftc and Poorlmentioning
confidence: 99%
See 2 more Smart Citations
“…Thyroid oncocytic cells have been associated with mitochondrial abnormalities, such as deficiencies in energy-related functions, impaired protein synthesis, and loss of electron transport components (Maximo and Sobrinho-Simoes, 2000).…”
mentioning
confidence: 99%