Hyaluronan and cell locomotion

Turley, Eva A.

doi:10.1007/bf00047600

Cited by 187 publications

(121 citation statements)

References 46 publications

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“…This receptor has recently been observed on lymphoid cells and mediates rapid migration over HYA covered surfaces [52]. It has been implicated in a number of physiological processes, including cell migration, lymphocyte activation and tumour progression.…”

Section: Discussionmentioning

confidence: 99%

Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation

Gerdin

Hällgren

1997

Journal of Internal Medicine

124

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Gerdin B, Hällgren R (University Hospital, Uppsala, Sweden). Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation (Minisymposium: Hyaluronan). J Intern Med 1997; 242: 49–55. An increased tissue accumulation of HYA occurs in several human and experimental inflammatory conditions. Such is the case in sarcoidosis, idiopathic pulmonary fibrosis and farmer's lung in man, and experimental bleomycin‐induced lung damage in rats. Graft rejection in man and rats, experimental myocarditis in mice and myocardial infarction in rats follow the same pattern. Increased amounts of HYA also appear in gut luminal perfusion fluid in human inflammatory bowel disease. A transient accumulation of HYA is seen in wound healing, which is more sustained in fetuses. An increased accumulation of water and presentation of ligands for receptors on inflammatory cells are two consequences of the HYA accumulation.

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Section: Discussionmentioning

confidence: 99%

Dynamic role of hyaluronan (HYA) in connective tissue activation and inflammation

Gerdin

Hällgren

1997

Journal of Internal Medicine

124

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“…Hence, these hyaluronan-based vehicles provide differential cuing as intact scaffolds and during their degradation. This sequential cuing can be observed in major mesenchymal transitions during embryonic developrncnt (48)(49)(50). The succcssful mimicking of embryonic extracellular matrix changes may be a guiding principle for engineering reparative processes in adult tissues.…”

Section: A Solchaga Et a Lmentioning

confidence: 95%

Hyaluronan‐based polymers in the treatment of osteochondral defects

Solchaga

Yoo

Lundberg

et al. 2000

Journal Orthopaedic Research

212

131

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Summary: Articular cartilage in adults has limited ability for self-repair. Some methods devised to augment the natural healing response stimulate some regeneration, but the repair is often incomplete and lacks durability. Hyaluronan-based polymers were tested for their ability to enhance the natural healing response. It is hypothesized that hyaluronan-based polymers recreate an embryonic-like milieu where host progenitor cells can rcgcncrate the damaged articular surface and underlying bone. Oskochondral dcfccts were made on the femoral condyles of 4-month-old rabbits and were left empty or filled with hyaluronan-based polymers. The polymers tested were ACP sponge. made of crosslinked hyaluronan, and HYAFF-11 sponge, made of benxylated hyaluronan. The rabbits were killed 4 and 12 weeks after surgery, and the condyles were processed for histology. All 12-week defects were scored with a 29-point scale, and the scores were compared with a Kruskall-Wallis analysis of variance on ranks. Untreated defects filled with bone tissue up to or beyond the tidemark, and the noncalcified surface layer varied from fibrous to hyaline-like tissue. Four weeks aftcr surgery, defects treated with ACP exhibited bone filling to the level of the tidemark and the surface layer was composed of hyaline-like cartilage well integrated with the adjacent cartilage. At 12 weeks, the specimens had bone beyond the tidemark that was covered with a thin layer of hyaline cartilage. Four weeks after surgery, defects treated with HYAFF-11 contained a rim of chondrogcnic cells at the interface of the implant and the host tissue. In general, the 12-week dcfccts exhibited good bone fill and the surface was mainly hyaline cartilage. Treated defects received significantly higher scores than untreated defects (p < 0.05), and ACP-trcatcd defects scored significantly higher than HYAFF-11-treated defects (p < 0.05). The introduction of these hyaluronan-based polymers into delects provides an appropriate scaffolding and favorable microenvironnient for the reparative process. Further work is required to lully assess thc long-term outcome of defects treated with these polymers.The successful regeneration of any tissue requires not oiily reparative cells with the potential to differentiate into the phenotypes required to restore the damaged site but also a microenvironment that supports the proliferation and differentiation of those cells (12). It is our hypothesis that these reparative cells recapitulate, a t least in part. the sequence of events that leads to the formation of differentiated tissues during embryonic development; therefore. materials that mimic an embryonic environment may be superior scaffolds for tissue-engineered repair of damaged tissues.Articular cartilage has no vascular supply or easy access to large quantities of progenitor cells: thus, cartilage repair is often unsuccessful. Some studies indicate that full-thickness lesions in young animals are

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“…Among the ECM molecules which can promote tumor cell migration and/or chemo-and haptotaxis are hyaluronan, laminin, fibronectin, type IV collagen, and type I-trimer collagen but not normal type I collagen. 30,[88][89][90] As discussed above, degradation of basement membranes results in the solubilization of ECM fragments which then might have chemotactic effects. This is particularly important in the light of the observation that separate domains of thrombospondin have chemo-and haptotactic activities, respectively.…”

Section: Metastasismentioning

confidence: 99%