Hyaluronan and wound healing: a new perspective

Burd, D. Andrew R.; Ritz, Morris; Regauer, Sigrid; Longaker, Michael T.; Siebert, John W.; Garg, Hari G.

doi:10.1016/0007-1226(91)90093-y

Cited by 106 publications

(51 citation statements)

References 30 publications

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“…33,34 We used a polysaccharide gel containing two polymers, alginate and chitosan, as a delivery vector for DMAPT and DMAMCL. 35 Chitosan is a biocompatible and biodegradable polymer.…”

Section: Dmamcl Ameliorates Colitis Symptoms In a Mouse Model Of Dss-mentioning

confidence: 99%

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Viennois

Xiao

Ayyadurai

et al. 2014

Laboratory Investigation

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Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal (GI) tract associated with an increased risk of colorectal cancer (CRC). Current treatments for both IBD and colitis-associated CRC suffer from numerous side effects. Parthenolide (PTL) is a sesquiterpene lactone with anti-inflammatory activity, and previous studies have demonstrated that PTL is a potent inhibitor of the NF-kB pathway. Micheliolide (MCL), substantially more stable than PTL in vivo, was recently developed, and this study aimed to decipher its suitability as therapeutic tool for IBD and IBDassociated diseases. Similar to PTL, MCL inhibited NF-kB activation and subsequent pro-inflammatory pathways activation in vitro. Pro-drug forms of both compounds inhibited the DSS-induced colitis when administrated intraperitoneally or encapsulated in a polysaccharide gel designed to release drugs in the colon. Interestingly, MCL was found to attenuate carcinogenesis in AOM/DSS-induced CRC, thus providing new candidate for the treatment of inflammatory bowel disease and CRC.Laboratory Investigation (2014) 94, 950-965;

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“…33,34 We used a polysaccharide gel containing two polymers, alginate and chitosan, as a delivery vector for DMAPT and DMAMCL. 35 Chitosan is a biocompatible and biodegradable polymer.…”

Section: Dmamcl Ameliorates Colitis Symptoms In a Mouse Model Of Dss-mentioning

confidence: 99%

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Viennois

Xiao

Ayyadurai

et al. 2014

Laboratory Investigation

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“…CRT was originally shown to be the biologically active component of a hyaluronic acid isolate from fetal sheep skin that accelerated wound healing in animal experimental models of cutaneous repair. [33][34][35] In consideration of potential candidates for targeted therapy for impaired wound healing, the present study was undertaken to determine whether CRT treatment could sufficiently improve wound healing in a porcine model of wound repair. This paradigm of tissue repair has been used to demonstrate the efficacy of various wound healing treatments, because this animal model most closely mimics human wound healing.…”

mentioning

confidence: 99%

Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects

Nanney

Woodrell

Greives

et al. 2008

The American Journal of Pathology

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137

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Extracellular functions of the endoplasmic reticulum chaperone protein calreticulin (CRT) are emerging. Here we show novel roles for exogenous CRT in both cutaneous wound healing and diverse processes associated with repair. Compared with platelet-derived growth factor-BB-treated controls, topical application of CRT to porcine excisional wounds enhanced the rate of wound re-epithelialization. In both normal and steroid-impaired pigs, CRT increased granulation tissue formation. Immunohistochemical analyses of the wounds 5 and 10 days after injury revealed marked up-regulation of transforming growth factor-␤3 (a key regulator of wound healing), a threefold increase in macrophage influx, and an increase in the cellular proliferation of basal keratinocytes of the new epidermis and of cells of the neodermis. In vitro studies confirmed that CRT induced a greater than twofold increase in the cellular proliferation of primary human keratinocytes, fibroblasts, and microvascular endothelial cells (with 100 pg/ml, 100 ng/ ml, and 1.0 pg/ml, respectively). Moreover, using a scratch plate assay, CRT maximally induced the cellular migration of keratinocytes and fibroblasts (with 10 pg/ml and 1 ng/ml, respectively). In addition, CRT induced concentration-dependent migration of keratinocytes, fibroblasts macrophages, and monocytes in chamber assays. These in vitro bioactivities provide mechanistic support for the positive biological effects of CRT observed on both the epidermis and dermis of wounds in vivo, underscoring a significant role for

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“…[31] HA provides a healing process through regeneration and growth rather than scarring and fibrosis. [21,22] However, this effect has been variable. [32] The molecular weight and the concentration of the preparation are critical to its potential beneficial effects.…”

Section: Discussionmentioning

confidence: 99%

“…This macromolecular network would prevent fibrous ingrowth from the surrounding tissues. [21][22][23] The other explanation was that HA, being an effective soft tissue lubricant, might decrease the new extracellular matrix formation due to the inhibition of mononuclear phagocytes and lymphocytes. [24] The goal of this clinical study was to compare the effects of repetitive injections of HA with placebo on the functional outcome after primary digital zone-II flexor tendon repair.…”

mentioning

confidence: 99%

Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

Özgenel¹,

Etöz²

2012

Ulus Travma Acil Cerrahi Derg

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AMAÇBu çalışmada, zon-II fleksör tendon onarımlarından sonra, iki haftalık süre içerisinde enjekte edilen 3 doz hyaluronik asit (HA) enjeksiyonunun plaseboya (salin) karşı etkinliği araştırıldı. GEREÇ VE YÖNTEMÇalışmaya İkinci parmak izole zon-II fleksör tendon hasarlanması olan 22 hasta dahil edildi. Tenorafi öncesi, parmaklar randomize olarak iki gruba ayrıldı; 11 parmakta tenorafi çevresine 3 doz HA enjekte edilirken, aynı şekilde salin enjekte edilen 11 parmak da plasebo grubunu oluşturdu. Birinci doz tenorafi sırasında verildi ve ilave 2 doz 1 hafta ara ile enjekte edildi. Operasyon sonrası Kleinert rehabilitasyon protokolü uygulandı. Eklem hareket açıklığı, 3. hafta, 3. ay ve uzun dönemde total aktif ve pasif eklem açıklığı ölçüle-rek değerlendirildi. Fonksiyonel sonuç, Strickland sınıflan-dırmasına göre belirlendi. BULGULARÜçüncü haftada eklem hareket açıklığı açısından iki grup arasında bir fark tespit edilmedi. Ancak, 3. ay ve uzun dö-nemde, eklem hareket açıklığında, HA enjekte edilen parmaklarda plasebo grubuna göre anlamlı derecede iyileşme olduğu gözlendi. SONUÇBu plasebo kontrollü ön çalışmada, mükerrer HA enjeksiyonlarının, primer tendon onarımında, muhtemelen adezyon azaltıcı etkisine bağlı olarak, klinik sonuçları iyileşti-rebildiği ileri sürülmektedir.Anahtar Sözcükler: Adezyon önleme; hyaluronik asit; tendon adezyonları; tendon onarımı.

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Hyaluronan and wound healing: a new perspective

Cited by 106 publications

References 30 publications

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer

Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects

Effects of repetitive injections of hyaluronic acid on peritendinous adhesions after flexor tendon repair: a preliminary randomized, placebo-controlled clinical trial

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