Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Travan, Andrea; Scognamiglio, Francesca; Borgogna, Massimiliano; Marsich, Eleonora; Donati, Ivan; Tarusha, Lorena; Grassi, Mario; Paoletti, Sergio

doi:10.1016/j.carbpol.2016.03.088

Cited by 38 publications

(40 citation statements)

References 66 publications

(79 reference statements)

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“…Although, the details of this mechanism remain unclear, our results were consistent with the finding that changes in the HA‐containing ECM affects the inflammatory response during wound healing . Modifying the HA‐containing ECM may also be relevant because HA‐containing biomaterials modify the wound‐healing process …”

Section: Discussionsupporting

confidence: 88%

Ointment vehicles regulate the wound‐healing process by modifying the hyaluronan‐rich matrix

Murasawa¹,

Furuta

Noda

et al. 2018

Wound Repair Regeneration

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Topical ointment consists of an active ingredient and vehicle, and the vehicle largely comprises the volume of the ointment. During the treatment of chronic wounds, such as pressure ulcers, the vehicle has been considered inactive, only serving as a carrier of the main pharmaceutical. However, recent reports have indicated that the vehicle has distinct clinical effects that depend on its physicochemical properties. Therefore, an understanding of the action mechanism of the ointment vehicle in wound tissue is necessary. In this study, we established a mouse model to analyze tissue reactions induced by the following ointment vehicles, an oil-inwater emulsion (EM) vehicle; a macrogol ointment (MO), which is a water-soluble, hydrophilic vehicle; and a MOs containing sucrose (MS). EM-treated wounds exhibited an inflammatory reaction characterized by tissue edema and thick granulation tissue; however, MO-and MS-treated wounds did not exhibit this reaction. Moreover, EM-treated wounds exhibited infiltration of inflammatory cells unlike MO-treated wounds. In contrast, the formation of collagenous tissue was dominantly observed in MO-treated wounds. Because the vehicle regulates the water environment of the wound, the water-holding extracellular matrix molecules, including hyaluronan (HA) and proteoglycan, were examined using immunohistochemical and biochemical methods. The versican G1 fragment, serum-derived HA-associated protein (SHAP) and HA (the VG1F-SHAP-HA) complex characteristically found in inflammatory conditions of pressure ulcers was found in EMtreated wounds. To histologically analyze the mechanism of action of the vehicle, we evaluated the ointment vehicle-wound tissue interface in an en bloc manner. Formation of the HA-containing complex was observed locally between the vehicle and wound surface. On the basis of these data, ointment vehicles regulate the wound-healing process through the formation of HA-rich extracellular matrices at the ointment-wound interface. This study provides a better understanding of the treatment of deep-pressure ulcers with focus on ointment vehicles.

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Section: Discussionsupporting

confidence: 88%

Ointment vehicles regulate the wound‐healing process by modifying the hyaluronan‐rich matrix

Murasawa¹,

Furuta

Noda

et al. 2018

Wound Repair Regeneration

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“…Recently, Travan et al [20] developed a biodegradable membrane based on alginate and hyaluronic acid; the presence of hyaluronic acid (HA) within these membranes was shown to promote fibroblasts proliferation and migration, thereby accelerating the wound healing process. A potential application of this membrane can be represented by the need of promoting a faster closure of intestinal wounds following an anastomotic procedure.…”

Section: Introductionmentioning

confidence: 99%

Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications

et al. 2016

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“…Alginates are anionic biopolymers and naturally unmodified polysaccharides, which consist of α‐ l ‐guluronic acid units, 1,4‐linked β‐ d ‐mannuronic acid, and the different units possess different numbers and sequentially distribute along the chain by covalent interlinking, resting with the alginate source that typically extracted from brown seaweeds . The common alginate gelling process and physical linking are through the exchange of Na + from alginate acid with divalent cations like Ca 2+ , Sr 2+ and Ba 2+ .…”

Section: Fabrication Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

275

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Hyaluronan delivery by polymer demixing in polysaccharide-based hydrogels and membranes for biomedical applications

Cited by 38 publications

References 66 publications

Ointment vehicles regulate the wound‐healing process by modifying the hyaluronan‐rich matrix

Ointment vehicles regulate the wound‐healing process by modifying the hyaluronan‐rich matrix

Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

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