Hyaluronan in non‐surgical and surgical periodontal therapy: a systematic review

Bertl, Kristina; Bruckmann, Corinna; Isberg, Per‐Erik; Klinge, Björn; Gotfredsen, Klaus; Stavropoulos, Andreas

doi:10.1111/jcpe.12371

Cited by 74 publications

(91 citation statements)

References 61 publications

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“…Therefore, a significant decline of PD (0.2-0.9 mm) and BOP (2.28-19.5 %) compared to control groups has been observed in clinical studies using HA at different concentrations and dosage forms [20]. Noteworthy, the application mode of HA and the appropriate carrier system are important parameters for periodontitis therapy [20]. Therefore, the aim of the present study was to examine the biocompatibility of HA administered on dentin and the consequent biological outcome on periodontal ligament (PDL) cells in vitro.…”

Section: Introductionmentioning

confidence: 94%

“…Moreover, HA has been linked with minimizing early bacterial recolonialization after and in combination with mechanical debridement [18,19]. Therefore, a significant decline of PD (0.2-0.9 mm) and BOP (2.28-19.5 %) compared to control groups has been observed in clinical studies using HA at different concentrations and dosage forms [20]. Noteworthy, the application mode of HA and the appropriate carrier system are important parameters for periodontitis therapy [20].…”

Section: Introductionmentioning

confidence: 98%

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Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

et al. 2016

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 98%

Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

et al. 2016

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“…A number of studies describe the use of exogenous HA in non‐surgical and surgical periodontal therapy with generally beneficial but moderate effects on surrogate outcome variables of periodontal inflammation, ie, bleeding on probing and residual pocket depth . However, only few studies exist on the use of HA in reconstructive periodontal surgery .…”

Section: Introductionmentioning

confidence: 99%

Activity of two hyaluronan preparations on primary human oral fibroblasts

Asparuhova

Kiryak

Eliezer

et al. 2018

J of Periodontal Research

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Background and Objective The potential benefit of using hyaluronan ( HA ) in reconstructive periodontal surgery is still a matter of debate. The aim of the present study was to evaluate the effects of two HA formulations on human oral fibroblasts involved in soft tissue wound healing/regeneration. Material and Methods Metabolic, proliferative and migratory abilities of primary human palatal and gingival fibroblasts were examined upon HA treatment. To uncover the mechanisms whereby HA influences cellular behavior, wound healing‐related gene expression and activation of signaling kinases were analyzed by qRT ‐ PCR and immunoblotting, respectively. Results The investigated HA formulations maintained the viability of oral fibroblasts and increased their proliferative and migratory abilities. They enhanced expression of genes encoding type III collagen and transforming growth factor‐β3, characteristic of scarless wound healing. The HA s upregulated the expression of genes encoding pro‐proliferative, pro‐migratory, and pro‐inflammatory factors, with only a moderate effect on the latter in gingival fibroblasts. In palatal but not gingival fibroblasts, an indirect effect of HA on the expression of matrix metalloproteinases 2 and 3 was detected, potentially exerted through induction of pro‐inflammatory cytokines. Finally, our data pointed on Akt, Erk1/2 and p38 as the signaling molecules whereby the HA s exert their effects on oral fibroblasts. Conclusion Both investigated HA formulations are biocompatible and enhance the proliferative, migratory and wound healing properties of cell types involved in soft tissue wound healing following regenerative periodontal surgery. Our data further suggest that in gingival tissues, the HA s are not likely to impair the healing process by prolonging inflammation or causing excessive MMP expression at the repair site.

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“…However, these studies are not complete and cover only some clinical applications such as HA application in periodontal disease. 20 The aim of the study is: to systematically review the published literature regarding all the therapeutic effects of HA on acute and chronic inflammatory disease in oral cavity; to clarify and classify the main application areas of HA in dentistry, the pathophysiological basis, and the schedule of postoperative HA application; and to evaluate the most effective parameters of HA use in the field of odontostomathology.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid: Perspectives in dentistry. A systematic review

Casale

Moffa

Vella

et al. 2016

Int J Immunopathol Pharmacol

164

137

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To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the soft periodontal tissue, gingiva, and periodontal ligament as well as to the hard tissue such as alveolar bone and cementum. Topical hyaluronic acid (HA) has recently been recognized as an adjuvant treatment for chronic inflammatory disease in addition to its use to improve healing after dental procedures. The aim of our work was to systematically review the published literature about potential effects of HA as an adjuvant treatment for chronic inflammatory disease, in addition to its use to improve healing after common dental procedures. Relevant published studies were found in PubMed, Google Scholar, and Ovid using a combined keyword search or medical subject headings. At the end of our study selection process, 25 relevant publications were included, three of them regarding gingivitis, 13 of them relating to chronic periodontitis, seven of them relating to dental surgery, including implant and sinus lift procedures, and the remaining three articles describing oral ulcers. Not only does topical administration of HA play a pivotal key role in the postoperative care of patients undergoing dental procedures, but positive results were also generally observed in all patients with chronic inflammatory gingival and periodontal disease and in patients with oral ulcers

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Hyaluronan in non‐surgical and surgical periodontal therapy: a systematic review

Cited by 74 publications

References 61 publications

Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

Effect of hyaluronic acid on morphological changes to dentin surfaces and subsequent effect on periodontal ligament cell survival, attachment, and spreading

Activity of two hyaluronan preparations on primary human oral fibroblasts

Hyaluronic acid: Perspectives in dentistry. A systematic review

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