Hyaluronan-Induced Stimulation of Corneal Wound Healing is a Pure Pharmacological Effect

Camillieri, Giovanni; Bucolo, Claudio; Rossi, Silvia; Drago, Filippo

doi:10.1089/jop.2004.20.548

Cited by 46 publications

(36 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sodium chloride, thanks to its osmotic power, allows water transfer from stroma to tears, and improve transiently corneal hydration state. Sodium hyaluronate has a protective and healing effect on corneal epithelium and allows a better local tolerance of the treatment [7,8].…”

Section: Discussionmentioning

confidence: 99%

Clinical Results After 5% Sodium Chloride Treatment in Post-operative Corneal Oedema

Yin¹,

Levy²

2018

J Eye Dis Disord

View full text Add to dashboard Cite

Background: Evaluate the effectiveness of a hyperosmolar 5% sodium chloride treatment in corneal oedema.Design: This prospective, randomized study was conducted in a universitary ophthalmology department setting.Participants: 95 patients with post-operative corneal oedema were separated in 2 groups: 45 patients in group 1 treated with hypertonic eye drops; 50 patients in group 2 without anti-oedematous. Methods:Patients in group 1 were treated with 5% sodium chloride hypertonic eye drops associated with 0.15% sodium hyaluronate in addition to the classical post-operative treatment for 1 month; and patients in group 2 were only treated with classical post-operative treatment (antibiotic, corticosteroids and artificial tears). Main outcome measures:Visual acuity, pachymetry and density were measured at 1 day, 7 days, 1 month, 3 months and 6 months following surgery. Results:Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.85 ± 0.64 logMAR vs. 1.46 ± 0.8 logMAR, p=0.024) and one month (0.42 ± 0.35 logMAR vs. 1.03 ± 0.86 logMAR, p=0.04) but was no longer different at three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, p=0.04), contrary to group 2 (p=0.96), but the difference between the 2 groups was not statistically significant (p=0.15). Corneal density was also not significantly different between the two groups.Conclusion: 5% sodium chloride hypertonic eye drops reduces significantly post-operative corneal oedema treatment as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Results After 5% Sodium Chloride Treatment in Post-operative Corneal Oedema

Yin¹,

Levy²

2018

J Eye Dis Disord

View full text Add to dashboard Cite

show abstract

“…Our results indicated that HA/high‐K artificial tears can promote corneal epithelial wound healing in the mechanical scraping model and 0.3 per cent HA/high‐K tears had a better, although statistically non‐significant, effect than 0.15 per cent HA/high‐K tears. In previous studies, Camillieri and colleagues investigated the effect of topical hyaluronic acid solution in the rabbit model of mechanical abrasion and they found that 0.2 and 0.4 per cent hyaluronic acid solutions promoted corneal epithelial wound healing. Another study by Yang and colleagues also demonstrated the therapeutic effect of one per cent cross‐linked hyaluronan gel in a rabbit model of mechanical abrasion.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, the therapeutic effect of topical hyaluronic acid has been determined in vivo . Different formulations of hyaluronic acid, such as 1.0 to 2.0 per cent hyaluronic acid gel, 0.1 to 0.4 per cent hyaluronic acid eye drops and cross‐linked hyaluronic acid gel, have been tested in previous studies and found to enhance corneal epithelial wound healing in animal models …”

mentioning

confidence: 99%

Enhanced corneal wound healing with hyaluronic acid and high‐potassium artificial tears

Chiang

Chang

et al. 2013

Clinical and Experimental Optometry

View full text Add to dashboard Cite

Background:The aim of this study was to investigate the therapeutic role of preservative-free artificial tears containing hyaluronic acid and high potassium ion concentration (HA/ high-K artificial tears) on mechanically scraped or alkali-induced corneal epithelial defects in rats. Methods: We created mechanically scraped epithelial defects on the corneas of 24 SpragueDawley (SD) rats (three groups of eight rats) and alkali-induced epithelial defects on the corneas of 27 SD rats (three groups of nine rats). Then we applied topical 0.3 per cent or 0.15 per cent HA/high-K artificial tears four times daily for 1.5 days and compared its effect with that of topical phosphate buffered saline (PBS). The fluorescein staining analysis and histological examination were performed immediately after and at 12, 24 and 36 hours after injury. Results:In the mechanical scraping model, the areas of fluorescein staining in the eyes after topical application of 0.3 per cent HA/high-K artificial tears were significantly smaller than those after PBS treatment at 12 and 24 hours after injury. At 36 hours, the staining areas of both 0.3 per cent and 0.15 per cent HA/high-K artificial tears-treated eyes were found to be significantly smaller than those of the PBS-treated eyes. In the alkali burn model, the promotion of corneal epithelial wound healing after treatment with 0.3 per cent and 0.15 per cent HA/high-K artificial tears was not significantly different compared to that after treatment with PBS. Conclusion: Hyaluronic acid and high potassium ion concentration artificial tears promoted corneal epithelial wound healing in the mechanical scraping model; however, in the alkali burn model, no significant beneficial effect of this treatment was observed.

show abstract

“…Auch Hyaluronsäure wirkt mukoadhäsiv, viskoelastisch, zytoprotektiv und wundheilungsfördernd. So vermag auch Hyaluronsäure die toxischen BAC-Wirkungen zu vermindern [3,19,20]. Die subjektiven und objektiven Parameter sind bei Anwendung dieses Polymers besser als bei unpolaren Polymeren [17,21].…”

Section: Therapeutic Strategies In Dry Eye Disease -A Survey Of Possiunclassified

Therapiestrategien beim Trockenen Auge - eine Übersicht über mögliche Substitutionstherapien und kausaltherapeutische Ansätze

Zimmermann¹,

Erb

2012

Klin Monatsbl Augenheilkd

View full text Add to dashboard Cite

Substitution therapy with artificial tears is the standard in dry eye disease. Nowadays there are a vast variety of different preparations. This article gives an overview of both new and old approaches to substitution therapy (one-, two- and three-phase preparations) as well as opportunities for the causal treatment. Here, we provide dry eye treatment options regarding sophisticated disease subgroups, classifications concerning the affected tear film layer (aqueous, mucinous or lipid phase), and immunological dysfunctions.

show abstract

Hyaluronan-Induced Stimulation of Corneal Wound Healing is a Pure Pharmacological Effect

Cited by 46 publications

References 11 publications

Clinical Results After 5% Sodium Chloride Treatment in Post-operative Corneal Oedema

Clinical Results After 5% Sodium Chloride Treatment in Post-operative Corneal Oedema

Enhanced corneal wound healing with hyaluronic acid and high‐potassium artificial tears

Therapiestrategien beim Trockenen Auge - eine Übersicht über mögliche Substitutionstherapien und kausaltherapeutische Ansätze

Contact Info

Product

Resources

About