Purpose: To report a cohort of patients diagnosed with retinal metastases (RM), and to integrate these new cases in a systematic review of the literature, analyzing the clinical features and prognosis factors of patients with RM.Methods: We conducted a retrospective multicenter study including patients with RM. We also performed a full literature review of all published cases with a diagnosis of RM.Results: A total of six new cases were described on multimodal imaging. By combining the data from the literature and from our patients, we report the characteristics of a total of 69 patients. The most frequent primary tumor sites were cutaneous melanoma (36%), lung (23%), gastrointestinal tract (17%), and breast (12%). Multimodal imaging highlighted specific characteristics of RM. Fluorescein and indocyanine green angiography revealed early hypofluorescence followed by progressive filling of intrinsic dilated vessels. Optical coherence tomography demonstrated a hyperreflective intraretinal mass in all cases with or without subretinal fluid, hyperreflective intraretinal dots, or intraretinal fluid. Ultrasonography revealed a medium-high reflective dome-shaped tumor. Fifty-nine percent of the patients died during the follow-up with a mean survival time of 8.8 ± 8.7 months. Conclusion:We described here the clinical spectrum of RM and highlighted specific features of the disease.

Background: Evaluate the effectiveness of a hyperosmolar 5% sodium chloride treatment in corneal oedema.Design: This prospective, randomized study was conducted in a universitary ophthalmology department setting.Participants: 95 patients with post-operative corneal oedema were separated in 2 groups: 45 patients in group 1 treated with hypertonic eye drops; 50 patients in group 2 without anti-oedematous. Methods:Patients in group 1 were treated with 5% sodium chloride hypertonic eye drops associated with 0.15% sodium hyaluronate in addition to the classical post-operative treatment for 1 month; and patients in group 2 were only treated with classical post-operative treatment (antibiotic, corticosteroids and artificial tears). Main outcome measures:Visual acuity, pachymetry and density were measured at 1 day, 7 days, 1 month, 3 months and 6 months following surgery. Results:Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.85 ± 0.64 logMAR vs. 1.46 ± 0.8 logMAR, p=0.024) and one month (0.42 ± 0.35 logMAR vs. 1.03 ± 0.86 logMAR, p=0.04) but was no longer different at three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, p=0.04), contrary to group 2 (p=0.96), but the difference between the 2 groups was not statistically significant (p=0.15). Corneal density was also not significantly different between the two groups.Conclusion: 5% sodium chloride hypertonic eye drops reduces significantly post-operative corneal oedema treatment as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.

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