Hyaluronan Protects Bovine Articular Chondrocytes Against Cell Death Induced by Bupivacaine at Supraphysiologic Temperatures

Liu, Sen; Zhang, Qingsong; Hester, William; O’Brien, Michael J.; Savoie, Felix H.; You, Zongbing

doi:10.1177/0363546512439025

Cited by 16 publications

(11 citation statements)

References 30 publications

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“…This precaution is further supported by a study of patients with damaged cartilage 38. A recent in vitro study has shown that hyaluronan can prevent chondrocyte death caused by bupivacaine at supraphysiological temperatures 39. However, whether coinjection of hyaluronan and bupivacaine intra-articularly may alleviate bupivacaine’s chondrotoxicity awaits further evidence from in vivo studies.…”

Section: Local Toxicitiesmentioning

confidence: 99%

Liposomal extended-release bupivacaine for postsurgical analgesia

Lambrechts¹,

O’Brien²,

Savoie³

et al. 2013

PPA

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When physicians consider which analgesia to use postsurgery, the primary goal is to relieve pain with minimal adverse side effects. Bupivacaine, a commonly used analgesic, has been formulated into an aqueous suspension of multivesicular liposomes that provide long-lasting analgesia for up to 72 hours, while avoiding the adverse side effects of opioids. The increased efficacy of liposomal extended-release bupivacaine, compared to bupivacaine hydrochloride, has promoted its usage in a variety of surgeries including hemorrhoidectomy, bunionectomy, inguinal hernia repair, total knee arthroplasty, and augmentation mammoplasty. However, like other bupivacaine formulations, the liposomal extended-release bupivacaine does have some side effects. In this brief review, we provide an update of the current knowledge in the use of bupivacaine for postsurgical analgesia.

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Section: Local Toxicitiesmentioning

confidence: 99%

Liposomal extended-release bupivacaine for postsurgical analgesia

Lambrechts¹,

O’Brien²,

Savoie³

et al. 2013

PPA

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“…In osteoarthritis models, cartilage degeneration was reduced by HA [27,28]. Liu et al [19] reported that HA protected chondrocytes from death induced by bupivacaine at supraphysiologic temperatures. Grishko et al [29] reported that pretreatment of chondrocytes with HA can decrease mitochondrial DNA damage, preserve ATP levels, and increase cell viability.…”

Section: Discussionmentioning

confidence: 99%

“…Intra-articular injection of hyaluronic acid (HA) has been widely used in the treatment of osteoarthritis [18] because it has chondroprotective and cytoprotective effects [19,20]. In addition, several animal studies have suggested that intra-articular injection of MSCs with HA is a feasible and promising minimally invasive method for cartilage repair [21,22].…”

Section: Introductionmentioning

confidence: 99%

Intra-Articular Injection of Synovium-Derived Mesenchymal Stem Cells with Hyaluronic Acid Can Repair Articular Cartilage Defects in a Canine Model

Sato¹,

Takao²,

Miyamoto³

2015

J Stem Cell Res Ther

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Objective: The purpose of this study was to evaluate effectiveness of intra-articular injection of synovium-derived mesenchymal stem cells (SMSCs) and hyaluronic acid (HA) for the treatment of articular cartilage defects in a canine model. Methods: Forty-eight knees of 24 beagle dogs were randomly assigned to 16 groups (n=3) according to both the number of injected SMSCs (0.5×10 5 cells, 5×10 6 cells, 5×10 7 cells) and the concentration of HA (0%, 0.01%, 0.1%, 0.5%). A partial-thickness cartilage defect was created in the medial femoral condyle under arthroscopy. After seven weeks, autologous SMSCs with or without 1 ml HA were percutaneously injected into the injured knee. In the control group, 1 ml saline was injected. Twelve weeks after the injection, evaluation was performed using the International Cartilage Repair Society (ICRS) visual assessment scale and the modified O'Driscoll histological score. Results: The mean ICRS visual assessment scale and the mean modified O'Driscoll histological score were 1.0 ± 0.00 and 11.0 ± 0.00 in the control group. On the other hand, the mean ICRS visual assessment scale and the mean modified O'Driscoll histological score were 7.3 ± 3.21 and 30.7 ± 7.23 in the group injected with 5×10 6 cells and 0.01% HA. Conclusion: Intra-articular injection of SMSCs with HA may be effective for stimulating articular cartilage repair. Our results suggest that there is an ideal combination of the number of SMSCs and the concentration of HA for promoting articular cartilage repair.

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“…Following joint fluid aspiration, 5 ml of 1% lidocaine were injected into the knee joint, and then 2.5 ml hyaluronic acid (Artz, Kaken seiyaku, Japan) were injected using a same needle. Because previous in vitro studies have shown that local anesthetics are chondrotoxic to human articular cartilage (Grishko et al 2010 ; Piper et al 2011 ), hyaluronic acid was added in expectation of protecting articular cartilage (Hester et al 2012 ; Liu et al 2012 ). The knee joint was passively moved from extension to flexion 5 times.…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics of pain originating from intra-articular structures of the knee joint in patients with medial knee osteoarthritis

et al. 2013

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PurposeAlthough disease progression of osteoarthritis has been well documented, pain pathophysiology is largely unknown. This study was designed with two purposes: 1) to characterize patients with knee pain predominantly originating from intra-articular structures and 2) to describe the location and pattern of their pain.Materials and methods103 patients with medial knee osteoarthritis underwent an intra-articular injection of local anesthetics (joint block). At least 70% pain relief was defined as positive for the joint block, while less than 50% as negative. Pain characteristics in patients positive for joint block were evaluated in detail using a knee pain map.ResultsSixty three knees (61%) were positive and 33 knees (32%) were negative. Patients negative for the joint block were significantly higher age, suffered for longer time, and complained more diffuse pain. Although pain at anterior medial area during walk was the most common finding, pain characteristics differed among different knee areas.ConclusionThe characteristics of joint pain are widely variable even in patients with similar radiological features. Extra-articular sources are not negligible especially in older patients with a long history of diffuse pain. Differences in pain characteristics among knee areas should be taken into account when examining the pain source.

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Hyaluronan Protects Bovine Articular Chondrocytes Against Cell Death Induced by Bupivacaine at Supraphysiologic Temperatures

Abstract: Background-Bupivacaine and supraphysiologic temperature can independently reduce cell viability of articular chondrocytes. In combination these two deleterious factors could further impair cell viability.

Cited by 16 publications

References 30 publications

Liposomal extended-release bupivacaine for postsurgical analgesia

Liposomal extended-release bupivacaine for postsurgical analgesia

Intra-Articular Injection of Synovium-Derived Mesenchymal Stem Cells with Hyaluronic Acid Can Repair Articular Cartilage Defects in a Canine Model

Clinical characteristics of pain originating from intra-articular structures of the knee joint in patients with medial knee osteoarthritis

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