2021
DOI: 10.3390/biomedicines9111561
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Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

Abstract: Biofouling is the unwanted adsorption of cells, proteins, or intracellular and extracellular biomolecules that can spontaneously occur on the surface of metal nanocomplexes. It represents a major issue in bioinorganic chemistry because it leads to the creation of a protein corona, which can destabilize a colloidal solution and result in undesired macrophage-driven clearance, consequently causing failed delivery of a targeted drug cargo. Hyaluronic acid (HA) is a bioactive, natural mucopolysaccharide with excel… Show more

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Cited by 6 publications
(10 citation statements)
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“…The animals were intratumorally administered either citrate-, PTE-, or PEG-coated gold nanoparticles via syringe pump and then imaged again with μCT immediately postadministration (day 0) as well as on days 3, 6, and 9. Following controlled intratumoral injection, we observed via CT imaging that the citrate-GNPs consistently agglomerated as single clusters, a phenomenon also reported by our group after manual injection, 30 while the PTE-GNPs and PEG-GNPs diffused predominantly in the tumor periphery. In vivo results demonstrated remarkable differences in the intratumoral diffusion of the GNPs depending on the surface passivation.…”
Section: ■ Results and Discussionsupporting
confidence: 81%
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“…The animals were intratumorally administered either citrate-, PTE-, or PEG-coated gold nanoparticles via syringe pump and then imaged again with μCT immediately postadministration (day 0) as well as on days 3, 6, and 9. Following controlled intratumoral injection, we observed via CT imaging that the citrate-GNPs consistently agglomerated as single clusters, a phenomenon also reported by our group after manual injection, 30 while the PTE-GNPs and PEG-GNPs diffused predominantly in the tumor periphery. In vivo results demonstrated remarkable differences in the intratumoral diffusion of the GNPs depending on the surface passivation.…”
Section: ■ Results and Discussionsupporting
confidence: 81%
“…For elemental analysis, the whole tissue was digested except for certain tumors on day 3 ( n = 4 mice/group) and day 6 ( n = 4 mice/group) that were further subsectioned. From each of these tumors, four dissections were obtained (medial periphery, medial core, lateral periphery, and lateral core), following the previously described approach . Samples were digested as previously described .…”
Section: Methodsmentioning
confidence: 99%
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