Hyaluronic Acid After Subcutaneous Injection—An Objective Assessment

Santer, Verena; Molliard, Samuel Gavard; Micheels, Patrick; Río‐Sancho, Sergio del; Quinodoz, Pierre; Salomon, Denis

doi:10.1097/dss.0000000000001609

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…This may be explained by previous study findings where sharp needle injection with a perpendicular approach resulted in the dispersal of product into multiple anatomic layers (ie, subdermis and dermis) and inconsistent placement in the supraperiosteal layer. 38,39 The greater elasticity of the superficial anatomic layers significantly influences the HA gel distribution 40 which is likely portrayed through the changes in nasal volume.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the safety, efficacy, and longevity of two different hyaluronic acid fillers in filler rhinoplasty: A multicenter study

Rho¹,

Youn

Youn³

et al. 2021

Dermatologic Therapy

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Filler rhinoplasty is a popular procedure in Asia, and it is of great importance to understand the clinical efficacy and durability of the different filler products that serve this purpose. Here, we aimed to evaluate and compare the safety, efficacy, and longevity of two different hyaluronic acid (HA) fillers in improving the nasal profile in Asians. A multicenter comparative trial was performed for 48 weeks after a single injection of a popular monophasic monodensified, and a newly developed biphasic HA filler. Assessments including patient satisfaction and three‐dimensional (3D) imaging analysis were performed before, immediately after, 2 weeks, 12 weeks, 24 weeks, and 48 weeks after filler rhinoplasty. Twenty‐eight Korean women underwent structured rhinoplasty were divided into monophasic monodensified (n = 14) and biphasic (n = 14) groups. There were significant changes in the facial profile following filler rhinoplasty throughout the study period. Overall, an increase of 1.75 mm in nose height, increase of 3.66° in the nasofrontal angle and 2.77° in the nasolabial angle, and radix elevation of 1.24 mm was noted at week 48 which was statistically different from the baseline values (P < .05). Between the different filler types, statistical difference was only noted in radix elevation (per milliliter of filler material) immediately after filler injection. No serious adverse event occurred during treatment or follow‐up. Nonsurgical rhinoplasty with the specific HA filler products led to significant changes in the facial profile which persisted for 48 weeks. Overall, the clinical efficacy and safety were comparable between the two filler types except for radix elevation which was more prominent with C‐C immediately after filler injection. J‐V was superior to C‐C in maintaining the radix elevation long term.

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Section: Discussionmentioning

confidence: 99%

A comparison of the safety, efficacy, and longevity of two different hyaluronic acid fillers in filler rhinoplasty: A multicenter study

Rho¹,

Youn

Youn³

et al. 2021

Dermatologic Therapy

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“…Loss of volume in the lip occurs with age, making lip filler injections one of the most popular procedures in esthetic dermatology 2,3 . Hyaluronic acid (HA) fillers are commonly used for volume‐restoring procedures and wrinkles correction due to their versatility, biophysical characteristics, and compatibility 4 . HA dermal fillers are natural polymers stabilized by chemical crosslinking that provide temporary fullness while the body gradually absorbs them 5 .…”

Section: Introductionmentioning

confidence: 99%

Novel assessment of lip redness and microcirculation using optical coherence tomography after dermal filler injection

et al. 2023

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ObjectivesLip filler injections are one of the most popular procedures in esthetic dermatology. In this study, we used three‐dimensional colorimetric photography to assess lip color and optical coherence tomography‐angiography (OCT‐A), a noninvasive alternative to histopathology, to evaluate microcirculation after hyaluronic acid (HA) injection. The pain of the injection procedure was also assessed.MethodsAn average of 0.85cc of the total volume of HA with lidocaine was injected into the upper and lower lip of eighteen young (<30yo) and nine postmenopausal healthy women. OCT‐A, two‐dimensional, and three‐dimensional images were acquired immediately before (visit 1) and 15 days after injection (visit 2). Custom‐made software was used to analyze the imaging data to detect vessel morphology and redness changes. The Wong‐Baker FACES pain rating scale (0–10) was used to score the subject procedural pain.ResultsFor young and old subjects, three‐dimensional lip volume was greater than the injected volume. OCT‐A images of the lips showed higher vessel density and thickness, reaching statistical significance in the younger cohort. The overall trend of increased redness assessed by three‐dimensional colorimetric imaging and increased vascularity evaluated by OCT‐A imaging were similar. However, the correlation was not statistically significant for standard two‐dimensional digital photography. The average pain score after the first needle insertion and overall procedure were 2.9 and 3.5, respectively.ConclusionsThe results suggest an increased microvasculature network observed in OCT‐A images in young females. The increased blood vessel density and thickness observed by OCT‐A after HA lip filler injection is associated with increased lip redness and volume as assessed by colorimetric three‐dimensional photography; however, more research is needed to confirm these findings. This study presents OCT‐A as a novel noninvasive tool to investigate changes in lip microvascularity after HA filler injection and indicates that HA filler procedures may affect lip vascularity.

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“…In the context of anti-ageing management, we have previously described the behaviour of various Hyaluronic Acid (HA) gels following injection into the superficial, mid and deep reticular dermis [1][2][3][4]. We have also previously reported our observations regarding the subcutaneous injection of HA gel fillers, both ex vivo and in vivo [5][6][7][8]. In preparation for a lager study with planned longer-term follow-up, the main objective of this investigation was to observe the effects of different globally cohesive HA gel fillers following injection into the temporal fossa.…”

Section: Introductionmentioning

confidence: 99%

“…In preparation for a lager study with planned longer-term follow-up, the main objective of this investigation was to observe the effects of different globally cohesive HA gel fillers following injection into the temporal fossa. Injections were carried out under ultrasound guidance using the same methodology described in our previous studies [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Guided Injection of Hyaluronic Gel Filler in the Temples: A Report of Two Cases

Micheels¹,

Besse²,

Vandeputte³

2021

J Clin Cosmet Dermatol

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Hyaluronic Acid After Subcutaneous Injection—An Objective Assessment

Cited by 14 publications

References 15 publications

A comparison of the safety, efficacy, and longevity of two different hyaluronic acid fillers in filler rhinoplasty: A multicenter study

A comparison of the safety, efficacy, and longevity of two different hyaluronic acid fillers in filler rhinoplasty: A multicenter study

Novel assessment of lip redness and microcirculation using optical coherence tomography after dermal filler injection

Ultrasound-Guided Injection of Hyaluronic Gel Filler in the Temples: A Report of Two Cases

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