Hyaluronic acid-amorphous calcium phosphate nanoparticles for drug delivery and anticancer

Li, Min; Niu, Baolong; Guo, Xia; Rao, Chaohui; Li, Wenfeng

doi:10.1080/00914037.2020.1860982

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…Normally such molecules would influence the storage stability of ACPs via electrostatic interaction between the positively charged Ca 2+ and negatively charged groups. 24,25 Their effect on thermal crystallization still remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Wang

Sun

et al. 2022

CrystEngComm

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Section: Introductionmentioning

confidence: 99%

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Wang

Sun

et al. 2022

CrystEngComm

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“…However, there are certain challenges in its applications, including uncontrollable rapid precipitation leading to poor colloidal stability and dispersity, which hence persuades fluctuation in drug release handling and storage [ 93 , 94 ]. This rapid growth of calcium phosphate-nucleic acids particles circumscribes the in vivo repeatability [ 95 ].…”

Section: Strategies In Bone Targetingmentioning

confidence: 99%

“…Moreover, curcumin was loaded to the aforementioned system with 78% encapsulation efficiency successfully achieved controlled release at 30 h at pH 7.4. The system has good biocompatibility and anti-cancer activity assessed on A549 cells [ 94 ].…”

Section: Strategies In Bone Targetingmentioning

confidence: 99%

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

et al. 2022

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Bone metastasis has been considered the fatal phase of cancers, which remains incurable and to be a challenge due to the non-availability of the ideal treatment strategy. Unlike bone cancer, bone metastasis involves the spreading of the tumor cells to the bones from different origins. Bone metastasis generally originates from breast and prostate cancers. The possibility of bone metastasis is highly attributable to its physiological milieu susceptible to tumor growth. The treatment of bone-related diseases has multiple complications, including bone breakage, reduced quality of life, spinal cord or nerve compression, and pain. However, anticancer active agents have failed to maintain desired therapeutic concentrations at the target site; hence, uptake of the drug takes place at a non-target site responsible for the toxicity at the cellular level. Interestingly, lipid-based drug delivery systems have become the center of interest for researchers, thanks to their biocompatible and bio-mimetic nature. These systems possess a great potential to improve precise bone targeting without affecting healthy tissues. The lipid nano-sized systems are not only limited to delivering active agents but also genes/peptide sequences/siRNA, bisphosphonates, etc. Additionally, lipid coating of inorganic nanomaterials such as calcium phosphate is an effective approach against uncontrollable rapid precipitation resulting in reduced colloidal stability and dispersity. This review summarizes the numerous aspects, including development, design, possible applications, challenges, and future perspective of lipid nano-transporters, namely liposomes, exosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoparticulate gels to treat bone metastasis and induce bone regeneration. Additionally, the economic suitability of these systems has been discussed and different alternatives have been discussed. All in all, through this review we will try to understand how far nanomedicine is from clinical and industrial applications in bone metastasis.

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Hyaluronic acid-based self-assembled amorphous calcium phosphate for three-dimensionally conformal nano-coating for tissue ingrowth

Choy,

Lee

2024

Journal of Industrial and Engineering Chemistry

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Hyaluronic acid-amorphous calcium phosphate nanoparticles for drug delivery and anticancer

Cited by 3 publications

References 22 publications

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Effect of inositol on the thermally induced crystallization and phase evolution of amorphous calcium phosphate

Lipid-Based Nano-Sized Cargos as a Promising Strategy in Bone Complications: A Review

Hyaluronic acid-based self-assembled amorphous calcium phosphate for three-dimensionally conformal nano-coating for tissue ingrowth

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