Hyaluronic acid and hyaluronic acid: Sucrose nanogels for hydrophobic cancer drug delivery

Suner, Selin S.; Ari, Betül; Önder, Ferah Cömert; Özpolat, Bülent; Ay, Mehmet Oğuzhan; Şahiner, Nurettin

doi:10.1016/j.ijbiomac.2019.01.021

Cited by 50 publications

(19 citation statements)

References 36 publications

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“…The encapsulated curcumin was effective for a 15-day period indicated by tumor volume reduction by about five times compared to control tests. Suner et al [122] fabricated porous HA nanogels copolymers with sucrose (Suc). Nanogels (about 200 nm in size), were synthesized by engaging glycerol diglycidyl ether (GDE) as cross-linker with a single step reaction ( Figure 18).…”

Section: Hyaluronic Acid and Cancer Targeting Drugsmentioning

confidence: 99%

“…SEM images of (a) HA and (b) copolymeric HA/sucrose Suc nanogels. (c) Schematic representation of drug conjugation process to HA-based nanogels, and (d) Drug release profiles from drug-absorbed and -conjugated HA nanogels and drug-conjugated HA:Suc (HA/sucrose) nanogels at physiological condition at pH 7.4 buffer solution containing 5% DMSO solution at 37.5 • C. From [122].…”

Section: Hyaluronic Acid and Cancer Targeting Drugsmentioning

confidence: 99%

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Hyaluronic Acid and Controlled Release: A Review

2020

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Hyaluronic acid (HA) also known as hyaluronan, is a natural polysaccharide—an anionic, non-sulfated glycosaminoglycan—commonly found in our bodies. It occurs in the highest concentrations in the eyes and joints. Today HA is used during certain eye surgeries and in the treatment of dry eye disease. It is a remarkable natural lubricant that can be injected into the knee for patients with knee osteoarthritis. HA has also excellent gelling properties due to its capability to bind water very quickly. As such, it is one the most attractive controlled drug release matrices and as such, it is frequently used in various biomedical applications. Due to its reactivity, HA can be cross-linked or conjugated with assorted bio-macromolecules and it can effectively encapsulate several different types of drugs, even at nanoscale. Moreover, the physiological significance of the interactions between HA and its main membrane receptor, CD44 (a cell-surface glycoprotein that modulates cell–cell interactions, cell adhesion and migration), in pathological processes, e.g., cancer, is well recognized and this has resulted in an extensive amount of studies on cancer drug delivery and tumor targeting. HA acts as a therapeutic but also as a tunable matrix for drug release. Thus, this review focuses on controlled or sustained drug release systems assembled from HA and its derivatives. More specifically, recent advances in controlled release of proteins, antiseptics, antibiotics and cancer targeting drugs from HA and its derivatives were reviewed. It was shown that controlled release from HA has many benefits such as optimum drug concentration maintenance, enhanced therapeutic effects, improved efficiency of treatment with less drug, very low or insignificant toxicity and prolonged in vivo release rates.

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Section: Hyaluronic Acid and Cancer Targeting Drugsmentioning

confidence: 99%

Section: Hyaluronic Acid and Cancer Targeting Drugsmentioning

confidence: 99%

Hyaluronic Acid and Controlled Release: A Review

2020

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“…Compared with pure HA, the absorption bands at 1619 cm -1 and 1450 cm -1 from both HA NGs and HA@PPy NGs are respectively assigned to COO — anti-symmetric (ν as ) and symmetric stretching vibration (ν s ), respectively, and the intensity of the peaks significantly decreases after Cys crosslinking to form the NGs 26 . The bands at 1151 and 1085 cm -1 are associated with the stretching vibration of the primary alcohol in polysaccharide 30 . Moreover, the broad and overlapping bands appearing at 3432 cm -1 should be attributed to the O-H symmetric stretching vibrations (ν s ) of HA or the typical ν s (N-H) vibration of PPy.…”

Section: Resultsmentioning

confidence: 99%

Macrophage-mediated tumor homing of hyaluronic acid nanogels loaded with polypyrrole and anticancer drug for targeted combinational photothermo-chemotherapy

Xiao

Fan

et al. 2021

Theranostics

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Rationale: Development of nanosystems that can be integrated with macrophages (MAs), an emerging carrier system, for effective tumor therapy remains to be challenging. We report here the development of MAs specifically loaded with hyaluronic acid (HA) nanogels (NGs) encapsulated with a photothermal agent of polypyrrole (PPy) and anticancer drug doxorubicin (DOX) (HA/DOX@PPy NGs) for tumor homing and combination photothermo-chemotherapy. Methods: Cystamine dihydrochloride-crosslinked HA NGs were first prepared through a double emulsification method, then loaded with PPy via an in-situ oxidization polymerization and physically encapsulated with DOX. The created HA/DOX@PPy NGs were well characterized and subjected to be endocytosed by MAs (MAs-NGs). The MAs-mediated tumor-homing property, phenotype changes and photothermal performance of MAs-NGs were investigated in vitro , and a subcutaneous tumor model was also established to confirm their targeting capability and enhanced antitumor therapy effect in vivo . Results: The generated hybrid NGs possess a size around 77 nm and good colloidal stability, and can be specifically endocytosed by MAs without appreciably affecting their normal biofunctionalities. In particular, NG-loaded MAs display excellent in-vitro cancer cell and in-vivo tumor homing property. Systemic administration of the MAs-NGs leads to the significant inhibition of a subcutaneous tumor model through combination photothermo-chemotherapy under laser irradiation. Conclusions: The developed hybrid HA-based NG nanosystem incorporated with PPy and DOX fully integrates the coordination and heating property of PPy to regulate the optimized DOX release in the tumor region with the assistance of MA-mediated tumor homing, providing a promising cell therapy strategy for enhanced antitumor therapy.

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“…Hydrogels and nanogels can be prepared using synthetic [26][27][28] or natural polymers [29][30][31][32] or peptide sequences. 33,34 With respect to polymers, peptides exhibit several advantages such as high biocompatibility, biodegradability and tunability.…”

Section: Introductionmentioning

confidence: 99%