Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Seong, Yun Jeong; Lin, Guang Qiang; Kim, Byung Jun; Kim, Hyoun Ee; Kim, Sukwha; Jeong, Seol Ha

doi:10.1021/acsomega.9b01475

Cited by 38 publications

(31 citation statements)

References 51 publications

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“…Secondly, limited lubrication enhancement has been considered for the hydrogels in the treatment of OA [ 11 ]. Unlike conventional hydrogels, the hydrogel microspheres possess significantly enhanced injectability due to the spherical shape and relatively uniform size [ 12 ]. Additionally, the flowability and flexibility of the microspheres allow them to disperse adequately in the solution and fulfill the requirement of joint loading.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

Han

Yang

Zhao

et al. 2021

Bioactive Materials

163

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The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism. In this study, bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel, we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment. Particularly, the lubricating microspheres (GelMA@DMA-MPC) were fabricated by dip coating a self-adhesive polymer (DMA-MPC, synthesized by free radical copolymerization) on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres (GelMA, prepared via microfluidic technology), and encapsulated with an anti-inflammatory drug of diclofenac sodium (DS) to achieve the dual-functional performance. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres. In addition, the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model, and the biological tests including qRT-PCR, immunofluorescence staining assay, X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA. In summary, the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release, therefore representing a facile and promising technique for the treatment of OA.

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Section: Introductionmentioning

confidence: 99%

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

Han

Yang

Zhao

et al. 2021

Bioactive Materials

163

View full text Add to dashboard Cite

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“…However, a high injection force resulting from the presence of nanosized ceramic fillers and nonuniform shapes and sizes of gel granules is unavoidable [ 126 ]. To address this challenge, the injectable HA-based hybrid hydrogel MCs with nanosized calcium phosphate were fabricated using a W/O emulsion process and in situ precipitation process [ 127 ]. In clinical practice, uncross-linked HA is generally mixed as a lubricant.…”

Section: Appropriate Materials For Microcarriers In Cartilage Tementioning

confidence: 99%

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Ding

Liu

Zhao

et al. 2022

Bioactive Materials

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“…Controlled drug release, vital for pharmaceutical therapies in healthcare, is a dynamic, either pulsatile or extended-release of active compounds to avoid side effects and maintain a constant, topical, or plasma level of the medication in chronic diseases [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

et al. 2022

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(1) Background: The standard treatment for periodontal disease, a chronic inflammatory state caused by the interaction between biofilms generated by organized oral bacteria and the local host defense response, consists of calculus and biofilm removal through mechanical debridement, associated with antimicrobial therapy that could be delivered either systemically or locally. The present study aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a carrier for the controlled release of the active compounds of a formulation proposed as a topical treatment for periodontal disease, and the influence of pH on the complex system’s stability. (2) Methods: The obtained hyaluronic acid (HA) hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis, UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and dielectric analysis. The MTT viability test was applied to check the cytotoxicity of the obtained membranes, while the microbiological assessment was performed against strains of Staphylococcus spp. and Streptococcus spp. The spectrophotometric investigations allowed to follow up the release profile from the HA matrix for MEL, MZ, and T present in the topical treatment considered. We studied the behavior of the active compounds against the pH of the generated environment, and the release profile of the bioactive formulation based on the specific comportment towards pH variation. The controlled delivery of the bioactive compounds using HA as a supportive matrix was modeled applying Korsmeyer–Peppas, Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order kinetic model. (3) Results: It was observed that MZ and T were released at higher active concentrations than MEL when the pH was increased from 6.75, specific for patients with periodontitis, to a pH of 7.10, characterizing the healthy patients. Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 × 10−5 mol/L followed by a release decrease, while for MEL and T a short release plateau was recorded up to a concentration of 1.80 × 10−5 mol/L for MEL and 0.90 × 10−5 mol/L for T, followed by a continuous release; (4) Conclusions: The results are encouraging for the usage of the HA membrane matrix as releasing vehicle for the active components of the proposed topical treatment at a physiological pH.

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Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Cited by 38 publications

References 51 publications

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

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