Hyaluronic acid for periodontal tissue regeneration in intrabony defects. A systematic review.

Rodríguez, Alejandro; Iborra, I; Alpiste-Illueca, Francisco; López-Roldán, Andrés

doi:10.1016/j.dentre.2022.100057

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…The latter was used in the current study as recently, there has been a surge in the use of HA for cosmetic and medical reasons. In 2022, a systemic review by Rodríguez-Aranda et al [ 42 ] demonstrated favorable results with HA in periodontal regeneration. In the field of periodontology, HA has been advocated as monotherapy [ 43 ] or as an adjunct to non-surgical [ 44 ], surgical [ 45 ] or laser-assisted periodontal treatment [ 46 ] to reduce inflammation and promote wound healing.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial

Yakout,

Kamel,

Khadr

et al. 2023

BMC Oral Health

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Background Surgical gingivectomy can be considered the gold standard treatment for gingival enlargement. The healing of wound site after gingivectomy occurs slowly by secondary intention. To accelerate the wound healing process, several studies have been conducted evaluating the effect of various treatment modalities. Photobiomodulation therapy (PBMT) was proposed to provide minimally invasive and painless treatment as well as to decrease discomfort of the patient following the surgical process. Another factor that is expected to improve the healing after surgery is topical application of chemotherapeutic agents such as Hyaluronic acid (HA). This study aims to assess the effect of topically applied HA gel after PBMT on the healing of wound site after surgical gingivectomy. Methods This randomized controlled clinical trial included twenty-six surgical gingivectomy wound sites, equally divided into two groups, Group-I (test group): the surgical sites after gingivectomy were irradiated with a diode laser (980 nm, 0.2 W) then covered by 2% HA gel loaded in a special custom-made soft transparent tissue guard appliance for each patient. Group II (control group): the surgical sites were irradiated with a diode laser (980 nm, 0.2 W) only. Wound healing was assessed subjectively by Landry healing index on the 3rd, 7th, 14th and 21st days after surgery, and pain perception was assessed by the patients using visual analog scale (VAS) throughout the 21 days of the follow up period. Comparisons between the two study groups were performed using Mann-Whitney U test, while comparisons between different time points were performed using Friedman test. Significance was inferred at p value < 0.05. Results By the end of the follow-up period, surgical sites of the test group showed excellent healing compared to the control group. There were no significant differences in VAS scores between both groups (p > 0.05). Conclusions Application of 2% HA gel as an adjunctive to PBMT was found to have significant clinical effects and higher power of repair among test group when compared to that achieved by PBMT alone in control group. Trial registration This study was retrospectively registered on ClinicalTrials.gov and first posted on 28th of March 2023 with an identifier number: NCT05787912.

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Section: Discussionmentioning

confidence: 99%

Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial

Yakout,

Kamel,

Khadr

et al. 2023

BMC Oral Health

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“…In 2022, a systemic review by Rodríguez-Aranda et al (56) also demonstrated favourable results with HA in periodontal regeneration. This systemic review revealed improvements in terms of CAL, PPD, BOP, and radiographic parameters, when HA was used alone or in combination with bone graft or other biomaterials (56).…”

Section: Role Of Ha and Overview Of Studies In Periodontal Therapymentioning

confidence: 99%

Role of hyaluronic acid in periodontal therapy (Review)

et al. 2022

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Hyaluronic acid (HA) is essential for the function of extracellular matrices in both hard and soft periodontal components. HA plays an important role in the mechanisms underlying inflammation and wound healing. HA is located in periodontal tissues in differing amounts, including non-mineralized tissues, such as gingiva and periodontal ligament, and lower levels located in mineralized tissues, such as cementum and alveolar bone. According to preliminary findings, HA exhibits potential in the regulation of periodontal tissue regeneration and in the treatment of periodontal disease. HA promotes symptomatic relief in both marginal gingiva and deeper periodontal tissues. The present review aimed to examine the role of HA in periodontal therapy, and investigate the current literature supporting its use in periodontal regeneration. Contents1. Introduction 2. Properties of HA 3. Synthesis of HA 4. Role of HA in wound healing 5. Role of HA and overview of studies in periodontal therapy 6. Conclusion

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“…Thiol-modified HA hydrogels also enhanced gingival fibroblast adhesion, migration, and matrix deposition. Composite HA-gelatin hydrogels exhibited shear-thinning behavior favorable for injection [56]. Tuning the stability and mechanics of HA-based hydrogels holds promise for gingival scaffold development.…”

Section: Natural Biomaterialsmentioning

confidence: 99%

Regenerative Approaches in Gingival Tissue Engineering

H.S.A. Alyafei,

Anil

2024

Dentistry

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Gingival tissue engineering aims to regenerate damaged or diseased gingival tissues by applying biomaterials, growth factors, and stem cells. This chapter explores advancements and strategies in gingival tissue engineering. It begins by introducing the goals and anatomy/physiology of the gingiva. Biomaterial selection and design for gingival scaffolds and delivery methods for bioactive molecules to stimulate tissue growth are discussed. Stem cells are highlighted for their role in gingival regeneration - their isolation, characterization, and differentiation. Strategies like cell-based approaches, scaffold-free techniques, and hybrids combining cells, scaffolds, and growth factors are outlined. Preclinical and clinical studies assessing treatment safety/efficacy and methods to evaluate outcomes are reviewed. Challenges around improving cell viability, integration, and function are examined. Future directions focus on addressing these challenges. Ethical considerations and regulatory aspects are addressed to ensure responsible translation into clinical practice. This chapter provides insights into the current state and prospects of regenerative approaches in gingival tissue engineering, including their potential to impact gingival disease treatment and oral health promotion.

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Hyaluronic acid for periodontal tissue regeneration in intrabony defects. A systematic review.

Cited by 4 publications

References 38 publications

Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial

Efficacy of hyaluronic acid gel and photobiomodulation therapy on wound healing after surgical gingivectomy: a randomized controlled clinical trial

Role of hyaluronic acid in periodontal therapy (Review)

Regenerative Approaches in Gingival Tissue Engineering

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